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CDC25A is a member of the CDC25 family of phosphatases. antibodies-online currently ships Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Antibodies (370), and to destinations worldwide.
Show Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Antigene Profile
Showing 9 out of 13 Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) ELISA Kits
accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A
CDC 25A dephosphorylates NFAT (show NFATC1 ELISA Kits), resulting in translocation to nucleus and NFAT (show NFATC1 ELISA Kits) in co-operation with Smad2 (show SMAD2 ELISA Kits) promotes the tumor progression.
RSK (show RPS6KA1 ELISA Kits) promotes G2/M transition in mammalian cells through activating phosphorylation of Cdc25A and Cdc25B (show CDC25B ELISA Kits)
Triptolide induces S phase arrest via the promotion of p21 (show CDKN1A ELISA Kits) and p27 and the inhibition of cyclin A (show CCNA2 ELISA Kits) and CDC25A expression.
Overexpression of CDC25A was associated with the decrease of overall survival rates and disease-free survival in breast cancer patients.CDC25a is a target of HER2 (show ERBB2 ELISA Kits) signaling in human breast cancer.
Overexpression of EGFR (show EGFR ELISA Kits) in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes.
Data indicate that protein phosphatase inhibitor RE142 binds to one of the residues Cys384-Tyr386 of CDC25A, within a pocket adjacent to the catalytic site.
Our work provides novel insight into the underlying mechanisms by which FOXM1 controls the cell cycle through its association with CDC25A.
Studies indicate that the ATR (show ATR ELISA Kits)-Chk1 (show CHEK1 ELISA Kits)-Cdc25 (show CDC25C ELISA Kits) pathway is the sole checkpoint route in a majority of cancer cells.
destabilization of Cdc25A through inhibition of Hsp90 was boosted by the phosphorylation of Ser177 which tags Cdc25A to proteasomal degradation and this added up to the cell-cycle inhibitory effect
Cdc25A activity is required for the metaphase II arrest in mouse oocytes.
deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV
In the DNA damage response, instead of inhibiting cyclin B (show CCNB1 ELISA Kits)-CDK1 (show CDK1 ELISA Kits) through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B (show CDC25B ELISA Kits).
Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease.
CDC25A and CDC25B (show CDC25B ELISA Kits) but not CDC25C (show CDC25C ELISA Kits) compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
IL-7 (show IL7 ELISA Kits) drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1 (show FOXO1 ELISA Kits), leading to reduced expression of CD62L (show SELL ELISA Kits) and the migration of T cells into circulation.
Results reveal an unexpected role of Cdc25A down-regulation and the inhibitory phosphorylation of cdk2 (show CDK2 ELISA Kits) T14 (show CD27 ELISA Kits) and Y15 in cell cycle quiescence during muscle differentiation and implicate miRNAs-322 and -503 in the process.
Cdc25A degradation does not inhibit Cdk2 (show CDK2 ELISA Kits) activity because a considerable proportion of Cdk2 (show CDK2 ELISA Kits) molecules localize to the cytoplasm and centrosomes in mESCs, where they may be sheltered from regulation by nuclear Cdc25A.
human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest
cell division cycle 25 homolog A (S. pombe) (CDC25A)
, cell division cycle 25A (cdc25a)
, cell division cycle 25 homolog (cdc25)
, cell division cycle 25A (CDC25A)
, cell division cycle 25A (Cdc25a)
cell division cycle 25A
, cell division cycle 25 homolog A
, M-phase inducer phosphatase 1
, Dual specificity phosphatase Cdc25A
, CDC25A2-CAG isoform
, dual specificity phosphatase CDC25A
, dual specificity phosphatase Cdc25A
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.