Browse our CDC25A (CDC25A) ELISA Kits

Full name: Cell Division Cycle 25 Homolog A (S. Pombe) ELISA Kits (CDC25A)

Antigen Summary

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although...  More...
Synonyms:
cdc25A, CDC25A2, D9Ertd393e, sb:cb317
list all ELISA KIts Gene Name GeneID UniProt
CDC25A 993 P30304
CDC25A 171102 P48965
CDC25A 12530  

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More ELISA Kits for CDC25A Interaction Partners

Human Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) interaction partners

  1. let-7c suppresses HCC (show FAM126A ELISA Kits) progression, possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules. Let-7c may therefore be an effective therapeutic target for HCC (show FAM126A ELISA Kits).

  2. Results suggest that miR-449a may act as a tumor suppressor by targeting CDC25A in endometrial cancer.

  3. CDC25C (show CDC25C ELISA Kits) seems important for the phenotype of AML (show RUNX1 ELISA Kits) cells at least for a subset of patients. Many of the identified CDC25 (show RASGRF1 ELISA Kits) inhibitors show cross-reactivity among the three CDC25 (show RASGRF1 ELISA Kits) isoforms.

  4. Our results suggest that expression of CDC25B (show CDC25B ELISA Kits) may be used as a potential prognostic marker in the pathogenesis of retinoblastoma.

  5. These results suggest that Cdc25a promotes human cytomegalovirus replication and elevation of Cdc25a levels after human cytomegalovirus infection are due in part to human cytomegalovirus-mediated repression of miR (show MLXIP ELISA Kits)-21.

  6. miR-424(322)/503-dependent posttranscriptional downregulation of CDC25A cooperates with transcriptional repression of the CDC25A promoter and proteasome-mediated degradation to reduce the levels of CDC25A expression and to induce cell cycle arrest.

  7. Findings suggest that inhibition of H19 long non-coding RNA (LncRNAH19) and miR-675 expression can promote migration and invasion of hepatocellular carcinoma (HCC) cells via AKT/GSK-3beta/Cdc25A signaling pathway.

  8. accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A

  9. CDC (show CDK1 ELISA Kits) 25A dephosphorylates NFAT (show NFATC1 ELISA Kits), resulting in translocation to nucleus and NFAT (show NFATC1 ELISA Kits) in co-operation with Smad2 (show SMAD2 ELISA Kits) promotes the tumor progression.

  10. RSK (show RPS6KA1 ELISA Kits) promotes G2/M transition in mammalian cells through activating phosphorylation of Cdc25A and Cdc25B (show CDC25B ELISA Kits)

Mouse (Murine) Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) interaction partners

  1. These results showed that IGF1 (show IGF1 ELISA Kits) regulated the expression of BOULE (show BOLL ELISA Kits) and CDC25A mRNAs via ERK1/2 (show MAPK1/3 ELISA Kits) signaling and in T-independent pathway during spermatogenesis in the adult mouse testes.

  2. accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A

  3. Cdc25A activity is required for the metaphase II arrest in mouse oocytes.

  4. deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV

  5. In the DNA damage response, instead of inhibiting cyclin B-CDK1 (show CDK1 ELISA Kits) through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B (show CDC25B ELISA Kits).

  6. Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease.

  7. CDC25A and CDC25B (show CDC25B ELISA Kits) but not CDC25C (show CDC25C ELISA Kits) compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells

  8. IL-7 (show IL7 ELISA Kits) drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1 (show FOXO1 ELISA Kits), leading to reduced expression of CD62L (show SELL ELISA Kits) and the migration of T cells into circulation.

  9. Results reveal an unexpected role of Cdc25A down-regulation and the inhibitory phosphorylation of cdk2 (show CDK2 ELISA Kits) T14 (show CD27 ELISA Kits) and Y15 in cell cycle quiescence during muscle differentiation and implicate miRNAs-322 and -503 in the process.

  10. Cdc25A degradation does not inhibit Cdk2 activity because a considerable proportion of Cdk2 molecules localize to the cytoplasm and centrosomes in mESCs, where they may be sheltered from regulation by nuclear Cdc25A.

Xenopus laevis Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) interaction partners

  1. Cdc25A is a key player in the developmentally regulated program of apoptosis in X. laevis embryos

  2. Strong ERK (show MAPK1 ELISA Kits) activation can target Cdc25A for degradation in a manner similar to, but independent of, Chk1 (show CHEK1 ELISA Kits) for cell cycle arrest.

CDC25A Antigen Profile

Antigen Summary

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CDC25A

  • cell division cycle 25 homolog A (S. pombe) (CDC25A) Elisa Kit
  • cell division cycle 25A (cdc25a) Elisa Kit
  • cell division cycle 25 homolog (cdc25) Elisa Kit
  • cell division cycle 25A (CDC25A) Elisa Kit
  • cell division cycle 25A (Cdc25a) Elisa Kit
  • cdc25A Elisa Kit
  • CDC25A2 Elisa Kit
  • D9Ertd393e Elisa Kit
  • sb:cb317 Elisa Kit

Protein level used designations for CDC25A

cell division cycle 25A , cell division cycle 25 homolog A , M-phase inducer phosphatase 1 , Dual specificity phosphatase Cdc25A , CDC25A2-CAG isoform , dual specificity phosphatase CDC25A , dual specificity phosphatase Cdc25A

GENE ID SPECIES
460341 Pan troglodytes
733851 Xenopus (Silurana) tropicalis
57925 Danio rerio
420375 Gallus gallus
484780 Canis lupus familiaris
520188 Bos taurus
100064223 Equus caballus
993 Homo sapiens
171102 Rattus norvegicus
12530 Mus musculus
734734 Xenopus laevis
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