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CDC25A is a member of the CDC25 family of phosphatases. antibodies-online currently ships Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Antibodies (357), and to destinations worldwide.
Show Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Antigene Profile
Showing 9 out of 13 Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) ELISA Kits
Our work provides novel insight into the underlying mechanisms by which FOXM1 controls the cell cycle through its association with CDC25A.
Studies indicate that the ATR-Chk1-Cdc25 pathway is the sole checkpoint route in a majority of cancer cells.
destabilization of Cdc25A through inhibition of Hsp90 was boosted by the phosphorylation of Ser177 which tags Cdc25A to proteasomal degradation and this added up to the cell-cycle inhibitory effect
A new role for Rock2 in modulation of Cdc25A ubiquitination has been revealed, indicating a novel mechanism of Cdc25A regulation and a potential function for Rock2 in the development of hepatocellular carcinoma.
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.
Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2-p53-Cdc25A-p21-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis.
Cdc25A has an important physiological role in NF-kappaB activity regulation and it may be an important survival mechanism of cancer cells.
CDC25A deregulation may be involved in hematopoietic cells expansion in JAK2(V617F) patients, making this protein an attracting potential therapeutic target.
Cdc25A enhances Foxo1 stability by dephosphorylating Cdk2, and Foxo1 was shown to directly regulate transcription of the metastatic factor MMP1.
CDC25A, VAV1, TP73, BRCA1 and ZAP70 may be novel markers for predicting the effectiveness of radiotherapy in CRC patients.
deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV
In the DNA damage response, instead of inhibiting cyclin B-CDK1 through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B.
Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease.
CDC25A and CDC25B but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
IL-7 (show IL7 ELISA Kits) drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1, leading to reduced expression of CD62L and the migration of T cells into circulation.
Results reveal an unexpected role of Cdc25A down-regulation and the inhibitory phosphorylation of cdk2 T14 and Y15 in cell cycle quiescence during muscle differentiation and implicate miRNAs-322 and -503 in the process.
Cdc25A degradation does not inhibit Cdk2 activity because a considerable proportion of Cdk2 molecules localize to the cytoplasm and centrosomes in mESCs, where they may be sheltered from regulation by nuclear Cdc25A.
human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest
Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase
Studies of a transgenic mouse mammary tumor model identify Cdc25A as a candidate for human tumor latency modifier Apmt2.
cell division cycle 25A (CDC25A)
, cell division cycle 25A (Cdc25a)
, cell division cycle 25 homolog (cdc25)
, cell division cycle 25 homolog A (S. pombe) (CDC25A)
, cell division cycle 25A (cdc25a)
, M-phase inducer phosphatase 1
, dual specificity phosphatase CDC25A
, dual specificity phosphatase Cdc25A
, Dual specificity phosphatase Cdc25A
, cell division cycle 25A
, cell division cycle 25 homolog A
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.