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The protein encoded by CDC27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. Additionally we are shipping CDC27 Kits (7) and and many more products for this protein.
Showing 10 out of 126 products:
Dog (Canine) Monoclonal CDC27 Primary Antibody for IF, IP - ABIN967980
Kramer, Scheuringer, Podtelejnikov, Mann, Peters: Mitotic regulation of the APC activator proteins CDC20 and CDH1. in Molecular biology of the cell 2000
Show all 4 references for ABIN967980
Human Monoclonal CDC27 Primary Antibody for IHC, ELISA - ABIN969035
Goto, Eddy: Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. in The Journal of biological chemistry 2004
Show all 2 references for ABIN969035
Cow (Bovine) Polyclonal CDC27 Primary Antibody for EIA, WB - ABIN401313
Gabellini, Colaluca, Vodermaier, Biamonti, Giacca, Falaschi, Riva, Peverali: Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. in The EMBO journal 2003
Human Polyclonal CDC27 Primary Antibody for EIA, WB - ABIN499295
Peters: The anaphase promoting complex/cyclosome: a machine designed to destroy. in Nature reviews. Molecular cell biology 2006
miR (show MLXIP Antibodies)-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR (show MLXIP Antibodies)-27a and its downregulation conferred increased radioresistance of the cells.
These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
The structures show how one APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 recruits APC7 (show ANAPC7 Antibodies) to APC3.
Low cdc27 and high securin (show PTTG1 Antibodies) expression predict short survival for breast cancer patients.
Down-regulation of CDC27 protein is associated with radiation resistance.
Data indicate that additional density present in the anaphase-promoting complex (APC (show APC Antibodies)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7 (show ANAPC7 Antibodies), a subunit specific to vertebrate APC (show APC Antibodies)/C.
the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 (show MCPH1 Antibodies) and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1 (show MCPH1 Antibodies)-APC (show APC Antibodies)/C.
phosphorylation of Cdc27 by CKII (show CSNK2A1 Antibodies) is involved in TGF-beta (show TGFB1 Antibodies)-induced activation of APC (show APC Antibodies).
Cdc20 (show CDC20 Antibodies) requires APC3 and APC8 (show CDC23 Antibodies) to bind and activate the APC (show APC Antibodies)/C when the spindle assembly checkpoint is satisfied, but only APC8 (show CDC23 Antibodies) when active, and APC10 (show ANAPC10 Antibodies) is crucial for the destruction of cyclin B1 (show CCNB1 Antibodies) and securin (show PTTG1 Antibodies), but not cyclin A (show CCNA2 Antibodies)
the spindle checkpoint may regulate CDC27/APC (show APC Antibodies) activity at mitosis
Cdc27 directs cyclin D1 (show CCND1 Antibodies) to alternative degradation by anaphase promoting complex/cyclosome.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell division cycle 27 homolog (S. cerevisiae)
, cell division cycle 27 homolog
, cell division cycle protein 27 homolog
, CDC27 homolog
, anaphase promoting complex subunit 3
, anaphase-promoting complex subunit 3
, anaphase-promoting complex, protein 3
, nuc2 homolog