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anti-Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) Antibodies

The protein encoded by CDC45 was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Additionally we are shipping CDC45 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CDC45 8318 O75419
CDC45 12544 Q9Z1X9
CDC45 287961  
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Top anti-CDC45 Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-CDC45L Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Hela cell lysate WB Suggested Anti-CDC45L Antibody Titration: 0.5 ug/mlPositive Control: mouse stem cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CDC45L Antibody (Center) (ABIN653837) in 293 cell line lysates (35 µg/lane). CDC45L (arrow) was detected using the purified polyclonal antibody. CDC45L Antibody (Center) (ABIN653837) IHC analysis in formalin fixed and paraffin embedded testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE antibody diluted at 1:1000 ICC/IF Image CDC45L antibody [C1C3] detects CDC45L protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CDC45L protein stained by CDC45L antibody [C1C3] , diluted at 1:500. Blue: Hoechst 33342 staining. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated WB CDC45L monoclonal antibody (M02), clone 4C2 Western Blot analysis of CDC45L expression in Jurkat. Detection limit for recombinant GST tagged CDC45L is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti CDC45L Polyclonal Antibody, Unconjugated (ABIN873072) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated DB 50 μg Log in to see 7 to 9 Days
$285.71
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged CDC45L is approximately 3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details

CDC45 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-CDC45 Antibodies

  1. Human Polyclonal CDC45 Primary Antibody for FACS, IHC (p) - ABIN653837 : Ballabeni, Zamponi, Caprara, Melixetian, Bossi, Masiero, Helin: Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for ABIN653837

  2. Chicken Polyclonal CDC45 Primary Antibody for WB - ABIN2784521 : Hoskins, Marcuello, Altes, Marsh, Maxwell, Van Booven, Paré, Culverhouse, McLeod, Baiget: Irinotecan pharmacogenetics: influence of pharmacodynamic genes. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)

More Antibodies against CDC45 Interaction Partners

Xenopus laevis Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) interaction partners

  1. Data show that MRE11 (show MRE11A Antibodies)- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG (show CASK Antibodies)) helicase (show DNA2 Antibodies) complex.

Human Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) interaction partners

  1. The depletion of HDHB (show HELB Antibodies) from human cells diminishes Cdc45 association with chromatin, suggesting that HDHB (show HELB Antibodies) may facilitate Cdc45 recruitment at G1/S in human cells.

  2. Data suggest that CDC45 and MCM10 (minichromosome maintenance complex component 10 (show MCM10 Antibodies)) directly interact and establish a mutual co-operation in DNA binding; key domains appear to interact and then interact with DNA inside cells or in cell-free systems.

  3. CDC45 directly interact with MCM2-7 (show MCM2 Antibodies) proteins; with PSF2 (show TAP2 Antibodies), PSF3 (show GINS3 Antibodies) and SLD5 (show GINS4 Antibodies) in GINS subunits; and with replication protein A2 (show RPA2 Antibodies), AND-1. A considerable portion of CDC45 localizes in a region other than the DNA replication forks in nuclei.

  4. After UV-damage, Cdc45 is still present in a large multi-protein complex and that its mobility within living cells is consistently similar following UVC-mediated DNA damage.

  5. Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7 (show MCM2 Antibodies)/GINS (CMG (show CASK Antibodies) complex) leads to the formation of products >10 kb in length.

  6. Structural and functional insights into the DNA replication factor (show CDT1 Antibodies) Cdc45 reveal an evolutionary relationship to the DHH (show DHH Antibodies) family of phosphoesterases

  7. Cdc45, which is known to be required for replication fork progression, shows similar patterns of origin association to those of Timeless (show TIMELESS Antibodies)

  8. The coordinated binding of DUE-B and Cdc45 to origins and the physical interactions of DUE-B, Cdc45, and TopBP1 (show TOPBP1 Antibodies) suggest that complexes of these proteins are necessary for replication initiation.

  9. the Chk1 (show CHEK1 Antibodies)-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A (show CDC25A Antibodies)/Cdk2 (show CDK2 Antibodies)-independent mechanism

  10. MCM4 (show MCM4 Antibodies) phosphorylation by Cdc7 (show CDC7 Antibodies) kinase facilitates its interaction with Cdc45 on chromatin

Mouse (Murine) Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45) interaction partners

  1. Cdc45 Recapitulates Myc (show MYC Antibodies)-Dependent DNA Replication Stress.

  2. MCM4 (show MCM4 Antibodies) phosphorylation by Cdc7 (show CDC7 Antibodies) kinase facilitates its interaction with Cdc45 on chromatin

CDC45 Antigen Profile

Protein Summary

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CDC45

  • cell division cycle 45 (cdc45) antibody
  • cell division cycle 45 (CDC45) antibody
  • CDC45 cell division cycle 45-like (S. cerevisiae) (cdc45l) antibody
  • cell division cycle 45 (Cdc45) antibody
  • cell division cycle 45 homolog (S. cerevisiae) (CDC45) antibody
  • Cdc45l antibody
  • CDC45L2 antibody
  • PORC-PI-1 antibody

Protein level used designations for CDC45

CDC45 cell division cycle 45 homolog , cell division cycle 45 homolog , CDC45 cell division cycle 45-like , CDC45-related protein , cell division control protein 45 homolog , cell division cycle 45-like 2 , human CDC45 , PORC-PI-1

GENE ID SPECIES
779545 Xenopus (Silurana) tropicalis
100230478 Taeniopygia guttata
446991 Xenopus laevis
8318 Homo sapiens
12544 Mus musculus
287961 Rattus norvegicus
398081 Xenopus laevis
416776 Gallus gallus
486421 Canis lupus familiaris
507122 Bos taurus
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