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The protein encoded by CDC45 was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Additionally we are shipping CDC45 Proteins (5) and many more products for this protein.
Showing 10 out of 81 products:
Human Polyclonal CDC45 Primary Antibody for FACS, IHC (p) - ABIN653837
Ballabeni, Zamponi, Caprara, Melixetian, Bossi, Masiero, Helin: Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase. in The Journal of biological chemistry 2009
Show all 3 references for ABIN653837
Chicken Polyclonal CDC45 Primary Antibody for WB - ABIN2784521
Hoskins, Marcuello, Altes, Marsh, Maxwell, Van Booven, Paré, Culverhouse, McLeod, Baiget: Irinotecan pharmacogenetics: influence of pharmacodynamic genes. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Human Polyclonal CDC45 Primary Antibody for ICC, IF - ABIN442729
Hubbi, Kshitiz, Gilkes, Rey, Wong, Luo, Kim, Dang, Levchenko, Semenza: A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. in Science signaling 2013
Data show that MRE11 (show MRE11A Antibodies)- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG (show CASK Antibodies)) helicase (show DNA2 Antibodies) complex.
ectopic expression of Cdc45 led to increased firing of replication origins, severe replication stress, an early S-phase arrest, replication fork stalling, and eventually cell death by apoptosis.
The depletion of HDHB (show HELB Antibodies) from human cells diminishes Cdc45 association with chromatin, suggesting that HDHB (show HELB Antibodies) may facilitate Cdc45 recruitment at G1/S in human cells.
Data suggest that CDC45 and MCM10 (minichromosome maintenance complex component 10 (show MCM10 Antibodies)) directly interact and establish a mutual co-operation in DNA binding; key domains appear to interact and then interact with DNA inside cells or in cell-free systems.
CDC45 directly interact with MCM2-7 (show MCM2 Antibodies) proteins; with PSF2 (show TAP2 Antibodies), PSF3 (show GINS3 Antibodies) and SLD5 (show GINS4 Antibodies) in GINS subunits; and with replication protein A2 (show RPA2 Antibodies), AND-1. A considerable portion of CDC45 localizes in a region other than the DNA replication forks in nuclei.
After UV-damage, Cdc45 is still present in a large multi-protein complex and that its mobility within living cells is consistently similar following UVC-mediated DNA damage.
Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7 (show MCM2 Antibodies)/GINS (CMG (show CASK Antibodies) complex) leads to the formation of products >10 kb in length.
Structural and functional insights into the DNA replication factor (show CDT1 Antibodies) Cdc45 reveal an evolutionary relationship to the DHH (show DHH Antibodies) family of phosphoesterases
Cdc45, which is known to be required for replication fork progression, shows similar patterns of origin association to those of Timeless (show TIMELESS Antibodies)
The coordinated binding of DUE-B and Cdc45 to origins and the physical interactions of DUE-B, Cdc45, and TopBP1 (show TOPBP1 Antibodies) suggest that complexes of these proteins are necessary for replication initiation.
the Chk1 (show CHEK1 Antibodies)-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A (show CDC25A Antibodies)/Cdk2 (show CDK2 Antibodies)-independent mechanism
Cdc45 Recapitulates Myc (show MYC Antibodies)-Dependent DNA Replication Stress.
MCM4 (show MCM4 Antibodies) phosphorylation by Cdc7 (show CDC7 Antibodies) kinase facilitates its interaction with Cdc45 on chromatin
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CDC45 cell division cycle 45 homolog
, cell division cycle 45 homolog
, CDC45 cell division cycle 45-like
, CDC45-related protein
, cell division control protein 45 homolog
, cell division cycle 45-like 2
, human CDC45