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The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Additionally we are shipping CREG1 Antibodies (62) and CREG1 Kits (13) and many more products for this protein.
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Human CREG1 Protein expressed in Escherichia coli (E. coli) - ABIN1098379
Han, Luan, Sun, Guo, Guo, Tao, Deng, Wu, Liu, Yan, Li et al.: Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of ... in Journal of molecular and cellular cardiology 2011
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Results indicate that cellular repressor of E1A (show BCKDHA Proteins)-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation.
The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK (show EPHB2 Proteins)/cyclin E (show CCNE1 Proteins) signaling pathway.
CREG can inhibit NF-kappaB (show NFKB1 Proteins) activation, TNF-alpha (show TNF Proteins)-induced inflammatory responses and the hyperpermeability of endothelial cells.
miR (show MLXIP Proteins)-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation.
Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK (show MAPK14 Proteins)-dependent manner.
CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF (show VEGFA Proteins)/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway
Upregulation of CREG expression induced HUVEC migration.
Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A (show CCNA2 Proteins) and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition.
Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R (show IGF2R Proteins), modulating SMC (show DYM Proteins) phenotypic switching from contractile to proliferative.
no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population
CREG inhibits inflammation and promotes autophagy mediated by lysosome formation; it might be a potential therapeutic target in atherosclerosis.
CREG1 deficiency influenced the maturation of lysosomes and reduced the espression of Rab7 (show RAB7A Proteins), which might be involved in CREG1-induced cardiomyocyte autophagy.
Data indicate cellular repressor of E1A (show BCKDHA Proteins)-stimulated gene (CREG) as a factor in regulating endothelial differentiation and vasculogenesis via VEGF (show VEGFA Proteins)/PI3K/Akt (show AKT1 Proteins) pathway.
CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF (show VEGFA Proteins)/PI3K/AKT (show AKT1 Proteins) signaling pathway
These results indicate that CREG is expressed during mouse embryogenesis and might participate in the differentiation of these organs during embryogenesis.
Results show that CREG is a lysosomal protein that undergoes proteolytic maturation during biosynthesis, carries the mannose 6-phosphate recognition marker and depends on the interaction with M-6-P receptors for efficient delivery to lysosomes.
Secreted Creg inhibits cell proliferation mediated by mannose-6-phosphate/insulin-like growth factor II receptor (show IGF2R Proteins) in NIH 3T3 fibroblasts.
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation.
cellular repressor of E1A-stimulated genes 1
, protein CREG1
, Protein CREG1
, hypothetical protein