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Plays a role in mitotic exit and cytokinesis. Additionally we are shipping CEP55 Antibodies (57) and CEP55 Kits (12) and many more products for this protein.
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Cep55 may act as an MTOC-associated protein regulating spindle organization, and thus cell cycle progression during mouse oocyte meiotic maturation.
The results suggest that Cep55 and pericentrin are required for the stable bridge between germ cells during spermatogenesis and spermiogenesis.
TEX14 (show TEX14 Proteins) prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge.
In depth discussion of the functions of CEP55 across different effector pathways, and also its roles as a biomarker and driver of tumorigenesis, commemorating a decade of research on CEP55. [review]
Which was required for FLJ10540/MMP-7 (show MMP7 Proteins) or FLJ10540/MMP-10 (show MMP10 Proteins) expressions.
myotubularin-related protein 3 (show MTMR3 Proteins) and myotubularin-related protein 4 may act as a bridge between CEP55 and polo-like kinase 1, ensuring proper CEP55 phosphorylation and regulating CEP55 recruitment to the midbody.
CEP55 mRNA/protein expression was observed is specific to TCC (show SFXN1 Proteins) of human urinary bladder and might be used as a diagnostic biomarker and vaccine target in development of BC specific immunotherapy.
cellular proliferation was suppressed as a result of cell cycle arrest at the G2/M phase in CEP55-knockdown cells
FLJ10540 may be critical regulator of disease progression in nasopharygeal carcinoma, and the underlying mechanism may involve in the osteopontin (show SPP1 Proteins)/CD44 (show CD44 Proteins) pathway.
At the midbody, BRCA2 (show BRCA2 Proteins) influences the recruitment of endosomal sorting complex required for transport (ESCRT)-associated proteins, Alix (show PDCD6IP Proteins) and Tsg101 (show TSG101 Proteins), and formation of CEP55-Alix (show PDCD6IP Proteins) and CEP55-Tsg101 (show TSG101 Proteins) complexes during abscission.
the existence of a p53 (show TP53 Proteins)-Plk1-Cep55 axis in which p53 (show TP53 Proteins) negatively regulates expression of Cep55, through Plk1 which, in turn, is a positive regulator of Cep55 protein stability.
Data provide strong evidence that CEP55 and HELLS (show HELLS Proteins) may be used in conjunction with FOXM1 (show FOXM1 Proteins) as a biomarker set for early cancer detection and indicators of malignant conversion and progression.
Data show that Plk1 activity negatively regulates Cep55 to ensure orderly abscission factor recruitment and ensures that this occurs only once cell contraction has completed.
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis (By similarity).
centrosomal protein 55kDa
, centrosomal protein of 55 kDa-like
, centrosomal protein of 55 kDa
, cancer/testis antigen 111
, up-regulated in colon cancer 6
, hypothetical protein