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The protein encoded by CP is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Additionally we are shipping Ceruloplasmin (Ferroxidase) Antibodies (122) and Ceruloplasmin (Ferroxidase) Proteins (15) and many more products for this protein.
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Human CP ELISA Kit for Sandwich ELISA - ABIN414431
Li, Zheng, Huang, Lin, Zhao, Liao, Zhao, Lin, Gu: Screening disease-associated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study. in Chinese medical journal 2010
Show all 4 references for ABIN414431
In D-galactosamine-sensitized mice CP+Cu(II) increased the LPS (show TLR4 ELISA Kits)-induced lethality from 54 to 100%, while administration of antibodies against MIF (show MIF ELISA Kits) prevented the lethal effect. The enhancement by CP+Cu(II) of the pro-inflammatory signal of MIF (show MIF ELISA Kits) is discussed
mice with mutation of Cp and Heph (show HEPH ELISA Kits), iron accumulates in glia, while neurons have low iron levels. Both neurons and glia degenerate and mice become ataxic unless given an iron chelator.
Data (including data from studies in knockout mice) suggest that ceruloplasmin and hephaestin (show HEPH ELISA Kits) play distinct roles in regulation of gene expression in various regions of the brain and are involved in iron homeostasis.
Evidence supports a regulatory role of both proteins (Ceruloplasmin (CP) and beta-amyloid protein precursor (APP (show APP ELISA Kits))) in defence against iron-induced oxidative damage after TBI, which presents as a tractable therapeutic target.
Genetic interactions between Cp, Mon1a (show MON1A ELISA Kits), and the Slc40a1 (show SLC40A1 ELISA Kits) locus are involved in iron metabolism.
ceruloplasmin should provide a protective shield against inadvertent oxidant production by myeloperoxidase (show MPO ELISA Kits) during inflammation
The mouse ceruloplasmin gene has been mapped to chromosome 3.
Data found an increase in ceruloplasmin levels in the plasma of Npc1 (show NPC1 ELISA Kits) -/- mice compared to Npc1 (show NPC1 ELISA Kits) +/+ mice, and this increase was statistically significant (*p < 0.05).
Cp and Heph (show HEPH ELISA Kits) are necessary for iron export from the retina but are not essential for iron import into the retina.
Coronary atherosclerosis is distinguished by serum C4 complement up-regulation and ceruloplasmin down-regulation.
Data show that the concentration of ceruloplasmin (ferroxidase; Cp) was significantly higher in Low hemoglobin (Hb) compared to High Hb subsample.
serum ceruloplasmin level was lower in the primary open-angle glaucoma group in comparison to the group with only cataract.
The determination of serum ceruloplasmin in adolescents might be a useful tool to identify patients with the highest risk of future cardiovascular disease.
The main result of this study is that ceruloplasmin specific activity is associated with a decreased risk of developing Alzheimer's disease
pathological cerebrospinal fluid's environment of Parkinson's disease patients promoted the same modifications in the exogenously added ceruloplasmin
PON-1 (show PON1 ELISA Kits) and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia
we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers.
brain microvascular endothelial cell -secreted cytokine activity increases the gene expression of neighboring C6 glioma CP, which reciprocally acts on basolateral BMVEC ferroportin (show SLC40A1 ELISA Kits) to enhance brain iron import
High ceruloplasmin levels are associated with preeclampsia.
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
, hypothetical protein
, ceruloplasmin (ferroxidase)