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CHMP2B encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. Additionally we are shipping CHMP2B Proteins (10) and many more products for this protein.
Showing 10 out of 64 products:
Mouse (Murine) Polyclonal CHMP2B Primary Antibody for IHC, WB - ABIN350224
Lai, Chou, Chang, Liu, Lin: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. in Genome research 2000
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Human Monoclonal CHMP2B Primary Antibody for ELISA - ABIN393892
Ghanim, Guillot-Noel, Pasquier, Jornea, Deramecourt, Dubois, Le Ber, Brice,: CHMP2B mutations are rare in French families with frontotemporal lobar degeneration. in Journal of neurology 2010
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Human Monoclonal CHMP2B Primary Antibody for ELISA - ABIN393642
Tsai, Soong, Lin, Tu, Lin, Lee: FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS. in Neurobiology of aging 2011
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Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course
Protein kinase CK2 (show CSNK2A1 Antibodies) alpha (show CSNK2A2 Antibodies) is involved in the phosphorylation of the ESCRT-III subunits CHMP3 (show CHMP3 Antibodies) and CHMP2B, as well as of VPS4B/SKD1 (show vps4b Antibodies), an ATPase (show DNAH8 Antibodies) that mediates ESCRT-III disassembly.
Data indicate that knockdown of syntaxin 13 (syx13) further increased the cellular toxicity caused by muaant CHMP2B (CHMP2BIntron5) expression.
CHMP2B immunoreactivity was increased in the dorsal motor nucleus of the vagus nerve in Parkinson's disease and incidental Lewy body disease brains
These findings suggest that endosomal and autophagic pathway is associated with degradation or formation of alpha-synuclein (show SNCA Antibodies) aggregates in alpha-synucleinopathy.
Subjects with CHMP2B mutation show cognitive changes dominated by executive dysfunctions, years before they fulfil diagnostic criteria of FTD (show FTL Antibodies).
Direct link between disease-causing mutations and the cellular phenotype in cells originating from CHMP2B mutation patients with frontotemporal dementia.
This study provided a better understanding of the cellular pathogenesis of neurodegenerative diseases associated with various missense mutations of CHMP2B as well as endocytic defects.
CHMP2B polymerization scaffolds membranes in vivo represents a first step toward demonstrating its structural role during outward membrane deformation
recent advances in our understanding of the molecular basis of CHMP2B mutations indicate that the mechanisms involved may be broadly relevant to neurodegenerative processes.[review]
This study showing that CHMP2B resides at synapses and is involved in synaptic plasticity.
Forebrain-specific expression of frontotemporal dementia-associated mutant CHMP2B in mice causes several age-dependent neurodegenerative phenotypes, including social behavioral impairments.
Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 (show Lbx1 Antibodies) in the embryonic mouse neural tube
These data describe the first mouse model of dementia caused by CHMP2B mutation and provide new insights into the mechanisms of CHMP2B-induced neurodegeneration
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
chromatin modifying protein 2B
, charged multivesicular body protein 2b
, chromatin-modifying protein 2b
, VPS2 homolog B
, vacuolar protein-sorting-associated protein 2-2
, chromatin modifying protein 2B, like