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anti-Charged Multivesicular Body Protein 2B (CHMP2B) Antibodies

CHMP2B encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. Additionally we are shipping CHMP2B Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHMP2B 25978 Q9UQN3
CHMP2B 68942 Q8BJF9
CHMP2B 363720  
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Top anti-CHMP2B Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged CHMP2B is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged CHMP2B is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Chmp2b AntibodyTitration: 1.0 µg/mL  Positive Control: Rat Spleen 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IHC (p), WB CHMP2B Antibody (N-term) (ABIN657226) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Sheep Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$969.83
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Rat Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details

CHMP2B Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-CHMP2B Antibodies

  1. Mouse (Murine) Polyclonal CHMP2B Primary Antibody for IHC, WB - ABIN350224 : Lai, Chou, Chang, Liu, Lin: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. in Genome research 2000 (PubMed)
    Show all 5 references for ABIN350224

  2. Human Monoclonal CHMP2B Primary Antibody for ELISA - ABIN393642 : Ghanim, Guillot-Noel, Pasquier, Jornea, Deramecourt, Dubois, Le Ber, Brice,: CHMP2B mutations are rare in French families with frontotemporal lobar degeneration. in Journal of neurology 2010 (PubMed)
    Show all 5 references for ABIN393642

  3. Human Monoclonal CHMP2B Primary Antibody for ELISA - ABIN393892 : Tsai, Soong, Lin, Tu, Lin, Lee: FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS. in Neurobiology of aging 2011 (PubMed)
    Show all 5 references for ABIN393892

More Antibodies against CHMP2B Interaction Partners

Human Charged Multivesicular Body Protein 2B (CHMP2B) interaction partners

  1. Endogenous TMEM106B was partly sequestered in CHMP2B-positive structures. SNP T185 was more associated with CHMP2B than SNP S185, and it enhanced neurotoxicity caused by CHMP2B(Intron5) compared to S185-expressing cells.

  2. Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course

  3. Protein kinase CK2 (show CSNK2A1 Antibodies) alpha (show CSNK2A2 Antibodies) is involved in the phosphorylation of the ESCRT-III subunits CHMP3 (show CHMP3 Antibodies) and CHMP2B, as well as of VPS4B/SKD1 (show vps4b Antibodies), an ATPase (show DNAH8 Antibodies) that mediates ESCRT-III disassembly.

  4. Data indicate that knockdown of syntaxin 13 (syx13) further increased the cellular toxicity caused by muaant CHMP2B (CHMP2BIntron5) expression.

  5. CHMP2B immunoreactivity was increased in the dorsal motor nucleus of the vagus nerve in Parkinson's disease and incidental Lewy body disease brains

  6. These findings suggest that endosomal and autophagic pathway is associated with degradation or formation of alpha-synuclein (show SNCA Antibodies) aggregates in alpha-synucleinopathy.

  7. Subjects with CHMP2B mutation show cognitive changes dominated by executive dysfunctions, years before they fulfil diagnostic criteria of FTD (show FTL Antibodies).

  8. Direct link between disease-causing mutations and the cellular phenotype in cells originating from CHMP2B mutation patients with frontotemporal dementia.

  9. This study provided a better understanding of the cellular pathogenesis of neurodegenerative diseases associated with various missense mutations of CHMP2B as well as endocytic defects.

  10. CHMP2B polymerization scaffolds membranes in vivo represents a first step toward demonstrating its structural role during outward membrane deformation

Mouse (Murine) Charged Multivesicular Body Protein 2B (CHMP2B) interaction partners

  1. Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course

  2. This study showing that CHMP2B resides at synapses and is involved in synaptic plasticity.

  3. Forebrain-specific expression of frontotemporal dementia-associated mutant CHMP2B in mice causes several age-dependent neurodegenerative phenotypes, including social behavioral impairments.

  4. Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 (show Lbx1 Antibodies) in the embryonic mouse neural tube

  5. These data describe the first mouse model of dementia caused by CHMP2B mutation and provide new insights into the mechanisms of CHMP2B-induced neurodegeneration

CHMP2B Antigen Profile

Protein Summary

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Gene names and symbols associated with CHMP2B

  • charged multivesicular body protein 2B (CHMP2B) antibody
  • chromatin modifying protein 2Ba (chmp2ba) antibody
  • chromatin modifying protein 2B (CHMP2B) antibody
  • charged multivesicular body protein 2B (Chmp2b) antibody
  • chromatin modifying protein 2Bb (chmp2bb) antibody
  • 1190006E07Rik antibody
  • ALS17 antibody
  • CHMP2.5 antibody
  • chmp2b antibody
  • chmp2bl antibody
  • DMT1 antibody
  • RGD1306781 antibody
  • si:ch211-224m9.5 antibody
  • VPS2-2 antibody
  • VPS2B antibody
  • zgc:77025 antibody

Protein level used designations for CHMP2B

chromatin modifying protein 2B , charged multivesicular body protein 2b , chmp2b , chromatin-modifying protein 2b , VPS2 homolog B , vacuolar protein-sorting-associated protein 2-2 , chromatin modifying protein 2B, like

GENE ID SPECIES
487675 Canis lupus familiaris
569532 Danio rerio
747711 Pan troglodytes
100172566 Pongo abelii
100224229 Taeniopygia guttata
25978 Homo sapiens
68942 Mus musculus
363720 Rattus norvegicus
615954 Bos taurus
418461 Gallus gallus
100516044 Sus scrofa
405840 Danio rerio
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