CHMP2B antibody (AA 1-213)

Catalog No. ABIN7147523

Product Details anti-CHMP2B Antibody

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Binding Specificity: AA 1-213

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP2B antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Charged multivesicular body protein 2b protein (1-213AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHMP2B

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Alternative Name: CHMP2B (CHMP2B Products)

Synonyms: ALS17 antibody, CHMP2.5 antibody, DMT1 antibody, VPS2-2 antibody, VPS2B antibody, 1190006E07Rik antibody, RGD1306781 antibody, chmp2b antibody, chmp2bl antibody, zgc:77025 antibody, si:ch211-224m9.5 antibody, CHMP2B antibody, cg4618 antibody, chmp2.5 antibody, dmt1 antibody, vps2-2 antibody, vps2b antibody, CHMP2b-B antibody, chmp2b-a antibody, chmp2b-b antibody, charged multivesicular body protein 2B antibody, charged multivesicular body protein 2Bb antibody, charged multivesicular body protein 2Ba antibody, charged multivesicular body protein 2B pseudogene antibody, charged multivesicular body protein 2B S homeolog antibody, charged multivesicular body protein 2B L homeolog antibody, CHMP2B antibody, Chmp2b antibody, chmp2bb antibody, chmp2ba antibody, LOC747711 antibody, chmp2b.S antibody, chmp2b.L antibody

Background:

Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

Aliases: ALS17 antibody, Charged multivesicular body protein 2b antibody, CHM2B_HUMAN antibody, CHMP family, member 2B antibody, CHMP2.5 antibody, CHMP2b antibody, Chromatin modifying protein 2b antibody, Chromatin-modifying protein 2b antibody, DMT1 antibody, hVps2-2 antibody, Vacuolar protein sorting 2, yeast, homolog of, B antibody, Vacuolar protein sorting 2-2 antibody, Vacuolar protein sorting-associated protein 2-2 antibody, VPS2 homolog B antibody, Vps2-2 antibody, VPS2B antibody

UniProt: Q9UQN3