CHMP2B antibody (AA 1-213)

Catalog No. ABIN6138545

This Rabbit Polyclonal antibody specifically detects CHMP2B in WB and IF. It exhibits reactivity toward Human.

Quick Overview for CHMP2B antibody (AA 1-213) (ABIN6138545)

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CHMP2B Antibody

Binding Specificity: AA 1-213

Sequence: MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA KIGNKEACKV LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG AMSTTAKTMQ AVNKKMDPQK TLQTMQNFQK ENMKMEMTEE MINDTLDDIF DGSDDEEESQ DIVNQVLDEI GIEISGKMAK APSAARSLPS ASTSKATISD EEIERQLKAL GVD

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human CHMP2B (NP_054762.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CHMP2B

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Alternative Name: CHMP2B

Background: This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.,CHMP2B,ALS17,CHMP2.5,DMT1,VPS2-2,VPS2B,Signal Transduction,Cell Biology & Developmental Biology,Autophagy,Neuroscience,Neurodegenerative Diseases,Regulators,CHMP2B

Molecular Weight: 19 kDa/23 kDa

Gene ID: 25978

UniProt: Q9UQN3