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Chemokine (C-C Motif) Ligand 8 Proteins (CCL8)

CCL8 is one of several cytokine genes clustered on the q-arm of chromosome 17. Additionally we are shipping Chemokine (C-C Motif) Ligand 8 Antibodies (111) and Chemokine (C-C Motif) Ligand 8 Kits (91) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCL8 6355 P80075
CCL8 20307 Q9Z121
CCL8    
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Top Chemokine (C-C Motif) Ligand 8 Proteins at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
$4,173.75
Details
HOST_Escherichia coli (E. coli) Human SUMO Tag 10 μg Log in to see 16 Days
$140.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,NusA Tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 4 to 6 Days
$412.50
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 4 to 6 Days
$412.50
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$201.11
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   10 μg Log in to see 10 to 12 Days
$201.11
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details

CCL8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)
, ,
General

Top referenced Chemokine (C-C Motif) Ligand 8 Proteins

  1. Mouse (Murine) CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2666620 : Dean, Cox, Bellac, Doucet, Starr, Overall et al.: Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating ... in Blood 2008 (PubMed)
    Show all 7 references for ABIN2666620

  2. Human CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2666618 : Hori, Naishiro, Sohma, Suzuki, Hatakeyama, Yamamoto, Sonoda, Mizue, Imai, Tsutsumi, Kokai: CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. in Blood 2008 (PubMed)
    Show all 7 references for ABIN2666618

  3. Mouse (Murine) CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2007470 : Van Damme, Proost, Lenaerts, Opdenakker: Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. in The Journal of experimental medicine 1992 (PubMed)
    Show all 3 references for ABIN2007470

  4. Human CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2003693 : Kim, Rajarathnam, Clark-Lewis, Sykes: Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. in FEBS letters 1996 (PubMed)
    Show all 3 references for ABIN2003693

  5. Human CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN413600 : Kojima, Arikawa, Saita, Goto, Tsumura, Tanaka, Masunaga, Niki, Oomizu, Hirashima, Kohrogi: Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages. in American journal of respiratory and critical care medicine 2011 (PubMed)

More Proteins for Chemokine (C-C Motif) Ligand 8 (CCL8) Interaction Partners

Human Chemokine (C-C Motif) Ligand 8 (CCL8) interaction partners

  1. Dermal fibroblast CCL8 promotes melanoma metastasis.

  2. Authors show that the previously observed downregulation of hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A.

  3. CCL8 is an antimicrobial protein with bacteriocidal activity against E. coli.

  4. JAK2 (show JAK2 Proteins) and STAT3 (show STAT3 Proteins) activation is not essential for CCL3 (show CCL3 Proteins), CCL5 (show CCL5 Proteins) or CCL8 induced chemotaxis.

  5. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway.

  6. Macrophage Colony Stimulating Factor (show CSF2 Proteins) and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls.

  7. Cytokine treatment increases mRNA stability only for chemokines CCL2 (show CCL2 Proteins) and CCL8 in airway epithelium, and transient silencing and overexpression of human antigen R affects only chemokine (show CCL1 Proteins) CCL2 (show CCL2 Proteins) and CCL8 expression in primary and transformed epithelial cells.

  8. CCL8/MCP-2 is a target for mir (show MLXIP Proteins)-146a in HIV-1 infected microglia, as overexpression of mir (show MLXIP Proteins)-146a prevented HIV-induced secretion of MCP-2 chemokine (show CCL1 Proteins)

  9. TRAIL pretreatment of endothelial cells down-modulated mRNA steady-state levels of several TNF-alpha (show TNF Proteins)-induced chemokines, and it abrogated the TNF-alpha (show TNF Proteins)-mediated up-regulation of CCL8 and CXCL10 (show CXCL10 Proteins), modulating leukocyte/endothelial cell adhesion

  10. Angiotensin II directly stimulates MCP-2 expression through AT1 (show AGTR1 Proteins)-receptors in activated macrophages

Mouse (Murine) Chemokine (C-C Motif) Ligand 8 (CCL8) interaction partners

  1. tumours are characterized by expression of inflammatory chemokines (CCL2 (show CCL2 Proteins), CCL5 (show CCL5 Proteins), CCL7 (show CCL7 Proteins), CCL8, CCL12 (show Ccl12 Proteins), CXCL9 (show CXCL9 Proteins), CXCL10 (show CXCL10 Proteins) and CX3CL1 (show CX3CL1 Proteins)), reflected by an enrichment of activated Foxp3 (show FOXP3 Proteins)(-) and Foxp3 (show FOXP3 Proteins)(+) T cells

  2. these data reveal an important role for BLIMP1 (show PRDM1 Proteins) in modulating host defenses by suppressing expression of the chemokine (show CCL1 Proteins) CCL8.

  3. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt (show AKT1 Proteins) signaling pathway.

  4. Data indicate mRNA upregulation of CCR2 (show CCR2 Proteins) and CCR2 (show CCR2 Proteins) ligands CCL2 (show CCL2 Proteins), CCL7 (show CCL7 Proteins), CCL8, and CCL12 (show Ccl12 Proteins) in aortas from DOCA/salt-treated hypertension.

  5. Vitamin B6 supplementation downregulates Cd8a (show CD8A Proteins) and Ccl8 mRNA expression, so these candidate genes may play a protective role against colonic aberrant crypt foci development.

  6. early and preclinical expression of CCL8 in plasma predicts overall survival of graft-vs.-host disease (GVHD) mice. Together with an involvement of allo-recognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology.

  7. MCP (show CR1L Proteins)/CCL8 was induced via STAT3 (show STAT3 Proteins) and exhibited anti-tumor metastatic effect

  8. promotes atopic dermatitis by recruiting IL-5 (show IL5 Proteins)+ Th2 cells

  9. CCL8 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.

  10. Data show that that the stromal cell-derived chemokines CXCL12 (show CXCL12 Proteins) and CCL8 cooperate to attract hematopoietic progenitors with the potential to differentiate into regulatory DCs.

Chemokine (C-C Motif) Ligand 8 (CCL8) Protein Profile

Protein Summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.

Gene names and symbols associated with CCL8

  • chemokine (C-C motif) ligand 8 (CCL8)
  • chemokine (C-C motif) ligand 8 (Ccl8)
  • monocyte chemoattractant protein-2 precursor (MCP-2)
  • 1810063B20Rik protein
  • AB023418 protein
  • HC14 protein
  • MCP-2 protein
  • Mcp2 protein
  • Scya8 protein
  • SCYA10 protein

Protein level used designations for CCL8

C-C motif chemokine 8 , monocyte chemoattractant protein 2 , monocyte chemotactic protein 2 , small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2) , small-inducible cytokine A8 , monocyte chemoattractant protein-2 , small inducible cytokine A8 , monocyte chemotactic protein-2 , small chemokine ligand 8 , MCP-2 , chemokine ligand 8

GENE ID SPECIES
6355 Homo sapiens
20307 Mus musculus
448792 Canis lupus familiaris
100302703 Sus scrofa
281044 Bos taurus
101119572 Ovis aries
100033950 Equus caballus
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