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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Additionally we are shipping CXCR3 Kits (50) and CXCR3 Proteins (7) and many more products for this protein.
Showing 10 out of 295 products:
Human Monoclonal CXCR3 Primary Antibody for FACS, IHC - ABIN4899102
Falk, Singh, Faber, Nissen, Hviid, Sørensen: Dysregulation of CXCR3 expression on peripheral blood leukocytes in patients with neovascular age-related macular degeneration. in Investigative ophthalmology & visual science 2014
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Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895563
Clay, Rodrigues, Harvey, Leutenegger, Esser: Distinct chemokine triggers and in vivo migratory paths of fluorescein dye-labeled T Lymphocytes in acutely simian immunodeficiency virus SIVmac251-infected and uninfected macaques. in Journal of virology 2005
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Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895557
Chihara, Aranami, Oki, Matsuoka, Nakamura, Kishida, Yokoyama, Kuroiwa, Hattori, Okamoto, Murata, Toda, Miyake, Yamamura: Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica. in PLoS ONE 2013
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Human Polyclonal CXCR3 Primary Antibody for FACS, IF (p) - ABIN678653
Zhang, Fei, Gao, Liu, Zhang: The role of CXCR3 in the induction of primary biliary cirrhosis. in Clinical & developmental immunology 2011
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895543
Mackay, Rahimpour, Ma, Collins, Stock, Hafon, Vega-Ramos, Lauzurica, Mueller, Stefanovic, Tscharke, Heath, Inouye, Carbone, Gebhardt: The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. in Nature immunology 2013
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Human Polyclonal CXCR3 Primary Antibody for EIA, FACS - ABIN951214
Zhou, Tang, Qin, Gayed, Li, Skokos, Kyriakides, Pober, Tellides: CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. in The Journal of experimental medicine 2010
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Mouse (Murine) Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895547
Funakoshi, Shimizu, Numata, Ato, Melchers, Ohnishi: BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. in PLoS ONE 2015
Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895553
Tha-In, Metselaar, Tilanus, Groothuismink, Kuipers, de Man, Kwekkeboom: Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells. in Blood 2007
Human Polyclonal CXCR3 Primary Antibody for ELISA, WB - ABIN1535574
Marchese, Heiber, Nguyen, Heng, Saldivia, Cheng, Murphy, Tsui, Shi, Gregor: Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. in Genomics 1996
Human Monoclonal CXCR3 Primary Antibody for FACS - ABIN4895555
de-Oliveira-Pinto, Marinho, Povoa, de Azeredo, de Souza, Barbosa, Motta-Castro, Alves, Ávila, de Souza, da Cunha, Damasco, Paes, Kubelka: Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever. in PLoS ONE 2012
These data suggest that elevated IP-10 (show CXCL10 Antibodies) levels may impair NK cell function during HIV infection and that IP-10 (show CXCL10 Antibodies)/CXCR3 blocking may be a novel therapeutic strategy in the control and functional cure of HIV.
Our result showed that CXCR2 (show CXCR2 Antibodies) expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029) and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 (show CXCR2 Antibodies) and CXCR3 expressions are related to poorer overall survival (P < 0.001; P < 0.001).
The percentage of CXCR3(+) CD4 (show CD4 Antibodies)(+) TEM (show CYLD Antibodies) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG Antibodies)(+) CD4 (show CD4 Antibodies)(+) TCM cells expressing CCR6 (show CCR6 Antibodies)(+) or CCR4 (show CCR4 Antibodies)(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8 (show CD8A Antibodies)+NKG2D (show KLRK1 Antibodies)+ T cells into the skin
TNF-alpha (show TNF Antibodies) augments CXCR2 (show CXCR2 Antibodies) and CXCR3 to promote the progression of renal cell carcinoma (show MOK Antibodies) leading to a poor prognosis.
TLR9 (show TLR9 Antibodies) ligands may contribute to the immunopathogenesis of sarcoidosis via induction of CXCL10 (show CXCL10 Antibodies) release in the alveolar macrophages.
The CXCL10 (show CXCL10 Antibodies)/CXCR3 axis mediates T-cell recruitment into the skin in progressive vitiligo (show MITF Antibodies). Blocking this chemotactic mechanism may present a new form of therapy.
IP-10 (show CXCL10 Antibodies) complexes with CXCR3, which in turn activates the ERK1/2 (show MAPK1/3 Antibodies) pathway, thus resulting in upregulation of p-CREB (show CREB1 Antibodies) and increased vascular smooth muscle cell proliferation.
the CXCR3+/CCR5 (show CCR5 PLURAL_@2304@)+ expression was higher in the neoplastic as compared to the hyperplastic nodules.
monocytes and lymphocytes cooperate to enhance migration towards CXCR3 chemokines and CCL5 (show CCL5 Antibodies) in COPD (show ARCN1 Antibodies)
These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.
Cxcr3 is up-regulated by DNA demethylation and interaction with C/EBPalpha (show CEBPA Antibodies) which contributes to neuropathic pain.
These findings demonstrate that the CXCL10 (show CXCL10 Antibodies)/CXCR3 chemokine (show CCL1 Antibodies) pathway is critical in shaping CD8 (show CD8A Antibodies)(+) T cell immunity, locally within latently infected tissues, which protects against recurrent herpesvirus infection and disease.
this study shows that although T cell-specific expression of CXCR3 promotes the accumulation of CXCR3-expressing T cells during Leishmania donovani infection, this does not enhance resistance to visceral leishmaniasis; hepatic granuloma formation is impaired in CXCR3 transgenic mice
beta4GalT1 can regulate N-glycans of CXCR3 in RA. N-glycans of CXCR3 affects CXCL10 (show CXCL10 Antibodies)/CXCR3 ligand-binding which enhancing fibroblast-like synoviocytes invasion.
this study shows that diosgenin-mediated anti-allergic effects are associated with increased number of Foxp3 (show FOXP3 Antibodies)+ Treg cells expressing CXCR3
Circulating levels of chemokines that activate CXCR3 are elevated in non-obese diabetic (NOD) mice, consistent with clinical findings in human diabetes.
CXCR3 interacts with IL-10 (show IL10 Antibodies) secreted by CD8 (show CD8A Antibodies)+CD122 (show IL2RB Antibodies)+ regulatory T cells in a mouse model of Acute Lung Injury and promotes interferon-gamma (show IFNG Antibodies) and CXCL10 (show CXCL10 Antibodies) release.
This study demonstrates a previously unrecognized role of CXCR3 signaling in glial cells in negatively regulating Th17 cell expansion during experimental autoimmune encephalomyelitis
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor