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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Additionally we are shipping CXCR3 Antibodies (296) and CXCR3 Proteins (7) and many more products for this protein.
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Human CXCR3 ELISA Kit for Sandwich ELISA - ABIN366833
Zhang, Liu, Su, Shi, Chen: Serum fractalkine and interferon-gamma inducible protein-10 concentrations are early detection markers for acute renal allograft rejection. in Transplantation proceedings 2014
CD4(+)CXCR3(+) T cells are h (show LY75 ELISA Kits)ighly enriched in the inflamed mucosa (show IL10 ELISA Kits) of intestinal bowel disease patients.
CCL27 (show CCL27 ELISA Kits) drives baseline recruitment of Herpes simplex virus-specific CD8 (show CD8A ELISA Kits) T cells expressing CCR10 (show CCR10 ELISA Kits), while interferon (show IFNA ELISA Kits)-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation.
Up-regulation of CXCR3 chemokine (show CCL1 ELISA Kits) and its ligands in bronchoalveolar lavage fluid during organizing pneumonia increases the risk of chronic lung allograft dysfunction after lung transplantation.
These data suggest that elevated IP-10 (show CXCL10 ELISA Kits) levels may impair NK cell function during HIV infection and that IP-10 (show CXCL10 ELISA Kits)/CXCR3 blocking may be a novel therapeutic strategy in the control and functional cure of HIV.
Our result showed that CXCR2 (show CXCR2 ELISA Kits) expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029) and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 (show CXCR2 ELISA Kits) and CXCR3 expressions are related to poorer overall survival (P < 0.001; P < 0.001).
The percentage of CXCR3(+) CD4 (show CD4 ELISA Kits)(+) TEM (show CYLD ELISA Kits) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG ELISA Kits)(+) CD4 (show CD4 ELISA Kits)(+) TCM cells expressing CCR6 (show CCR6 ELISA Kits)(+) or CCR4 (show CCR4 ELISA Kits)(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8 (show CD8A ELISA Kits)+NKG2D (show KLRK1 ELISA Kits)+ T cells into the skin
TNF-alpha augments CXCR2 and CXCR3 to promote the progression of renal cell carcinoma leading to a poor prognosis.
TLR9 (show TLR9 ELISA Kits) ligands may contribute to the immunopathogenesis of sarcoidosis via induction of CXCL10 (show CXCL10 ELISA Kits) release in the alveolar macrophages.
The CXCL10 (show CXCL10 ELISA Kits)/CXCR3 axis mediates T-cell recruitment into the skin in progressive vitiligo (show MITF ELISA Kits). Blocking this chemotactic mechanism may present a new form of therapy.
ATF3 (show ATF3 ELISA Kits)-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10 (show CXCL10 ELISA Kits)-CXCR3 axis at multiple levels.
study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 (show CXCL10 ELISA Kits) and MIG (show CXCL9 ELISA Kits)
Antigen targeting to DEC-205 (show LY75 ELISA Kits) on dendritic cells leads to an IL-10 (show IL10 ELISA Kits)-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 (show HAND1 ELISA Kits) cells in vivo. This downregulation interferes with the migration of Th1 (show HAND1 ELISA Kits) cells into the gut (show GUSB ELISA Kits) and protects mice against severe acute and relapsing intestinal inflammation.
this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10 (show CXCL10 ELISA Kits)/CXCR3 axis
These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.
Cxcr3 is up-regulated by DNA demethylation and interaction with C/EBPalpha (show CEBPA ELISA Kits) which contributes to neuropathic pain.
These findings demonstrate that the CXCL10 (show CXCL10 ELISA Kits)/CXCR3 chemokine (show CCL1 ELISA Kits) pathway is critical in shaping CD8 (show CD8A ELISA Kits)(+) T cell immunity, locally within latently infected tissues, which protects against recurrent herpesvirus infection and disease.
this study shows that although T cell-specific expression of CXCR3 promotes the accumulation of CXCR3-expressing T cells during Leishmania donovani infection, this does not enhance resistance to visceral leishmaniasis; hepatic granuloma formation is impaired in CXCR3 transgenic mice
beta4GalT1 can regulate N-glycans of CXCR3 in RA. N-glycans of CXCR3 affects CXCL10 (show CXCL10 ELISA Kits)/CXCR3 ligand-binding which enhancing fibroblast-like synoviocytes invasion.
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor