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CHN2 is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. Additionally we are shipping Chimerin (Chimaerin) 2 Antibodies (56) and many more products for this protein.
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Study demonstrates that Sema3F (show SEMA3F Proteins)-dependent inhibition of Rac1 by the Rac (show AKT1 Proteins)-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.
the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation
CHN2 is consistently hypermethylated and downregulated in small bowel adenocarcinoma with diagnostic potential
CHN2, ABCB1 and PPP1R9A expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies.
genetic association studies in a population in Taiwan: Data suggest that an SNP in CHN2 (rs1002630) is associated with non-proliferative diabetic retinopathy in patients with diabetes type 2 in the Han Chinese population studied.
A significant association of the novel rs186911567 polymorphism was found for the CHN2 gene with smoking.
genetic association studies in a Chinese population with type 2 diabetes: An SNP in CHN2 (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.
beta 2 chimerin has a role in rac (show AKT1 Proteins)-GAP-dependent inhibition of breast cancer cell proliferation
Data demonstrate that beta2-chimaerin provides a novel, diacylglycerol-dependent mechanism for Rac (show AKT1 Proteins) regulation in T cells and suggest a functional role for this protein in Rac (show AKT1 Proteins)-mediated cytoskeletal remodeling.
Beta2-chimaerin regulates the proliferation and migration of vascular smooth muscle cells downstream of growth factor signaling pathway implicating human atherogenesis.
results suggest Tyr (show TYR Proteins)-21 phosphorylation of beta2-chimaerin as a novel, Src (show SRC Proteins)-family kinase-dependent mechanism that negatively regulates beta2-chimaerin Rac (show AKT1 Proteins)-GAP activity
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, chimerin (chimaerin) 2
, Rho GTPase-activating protein 3
, beta chimaerin
, chimaerin 2
, rho-GTPase-activating protein 3
, rho GTPase-activating protein 3