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Chimerin (Chimaerin) 2 Proteins (CHN2)

CHN2 is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. Additionally we are shipping Chimerin (Chimaerin) 2 Antibodies (53) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHN2 69993 Q80XD1
CHN2 1124 P52757
Rat CHN2 CHN2 84031 Q03070
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Top Chimerin (Chimaerin) 2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CHN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Chimerin (Chimaerin) 2 (CHN2) Interaction Partners

Mouse (Murine) Chimerin (Chimaerin) 2 (CHN2) interaction partners

  1. Study demonstrates that Sema3F (show SEMA3F Proteins)-dependent inhibition of Rac1 by the Rac (show AKT1 Proteins)-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.

  2. the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation

Human Chimerin (Chimaerin) 2 (CHN2) interaction partners

  1. CHN2 is consistently hypermethylated and downregulated in small bowel adenocarcinoma with diagnostic potential

  2. CHN2, ABCB1 and PPP1R9A expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies.

  3. genetic association studies in a population in Taiwan: Data suggest that an SNP in CHN2 (rs1002630) is associated with non-proliferative diabetic retinopathy in patients with diabetes type 2 in the Han Chinese population studied.

  4. A significant association of the novel rs186911567 polymorphism was found for the CHN2 gene with smoking.

  5. genetic association studies in a Chinese population with type 2 diabetes: An SNP in CHN2 (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.

  6. the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation

  7. beta 2 chimerin has a role in rac (show AKT1 Proteins)-GAP-dependent inhibition of breast cancer cell proliferation

  8. Data demonstrate that beta2-chimaerin provides a novel, diacylglycerol-dependent mechanism for Rac (show AKT1 Proteins) regulation in T cells and suggest a functional role for this protein in Rac (show AKT1 Proteins)-mediated cytoskeletal remodeling.

  9. Beta2-chimaerin regulates the proliferation and migration of vascular smooth muscle cells downstream of growth factor signaling pathway implicating human atherogenesis.

  10. results suggest Tyr (show TYR Proteins)-21 phosphorylation of beta2-chimaerin as a novel, Src (show SRC Proteins)-family kinase-dependent mechanism that negatively regulates beta2-chimaerin Rac (show AKT1 Proteins)-GAP activity

Chimerin (Chimaerin) 2 (CHN2) Protein Profile

Protein Summary

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with Chimerin (Chimaerin) 2 Proteins (CHN2)

  • chimerin (chimaerin) 2 (chn2)
  • beta chimerin (LOC100344407)
  • chimerin (chimaerin) 2 (CHN2)
  • chimerin 2 (CHN2)
  • chimerin (chimaerin) 2 (Chn2)
  • chimerin 2 (chn2)
  • chimerin 2 (Chn2)
  • 1700026N20Rik protein
  • 4930557O16Rik protein
  • ARHGAP3 protein
  • BCH protein
  • CHN2-3 protein
  • RHOGAP3 protein

Protein level used designations for Chimerin (Chimaerin) 2 Proteins (CHN2)

beta chimerin , chimerin (chimaerin) 2 , beta-chimaerin-like , beta-chimaerin , Rho GTPase-activating protein 3 , beta chimaerin , beta-chimerin , beta3-chimaerin , chimaerin 2 , rho-GTPase-activating protein 3 , rho GTPase-activating protein 3

GENE ID SPECIES
570999 Danio rerio
100344407 Oryctolagus cuniculus
472333 Pan troglodytes
475267 Canis lupus familiaris
697231 Macaca mulatta
100032581 Monodelphis domestica
100392207 Callithrix jacchus
100451463 Pongo abelii
100468141 Ailuropoda melanoleuca
100496459 Xenopus (Silurana) tropicalis
100541305 Meleagris gallopavo
100567151 Anolis carolinensis
100596099 Nomascus leucogenys
428437 Gallus gallus
507285 Bos taurus
69993 Mus musculus
444340 Xenopus laevis
1124 Homo sapiens
84031 Rattus norvegicus
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