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Chloride Channel 5 Proteins (CLCN5)

CLCN5 encodes a member of the ClC family of chloride ion channels and ion transporters. Additionally we are shipping Chloride Channel 5 Antibodies (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCN5 12728 Q9WVD4
CLCN5 1184 P51795
Rat CLCN5 CLCN5 25749 P51796
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Top Chloride Channel 5 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

CLCN5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

Top referenced Chloride Channel 5 Proteins

  1. Human Chloride Channel 5 Protein expressed in Wheat germ - ABIN1349570 : Hryciw, Jenkin, Simcocks, Grinfeld, McAinch, Poronnik: The interaction between megalin and ClC-5 is scaffolded by the Na?-H? exchanger regulatory factor 2 (NHERF2) in proximal tubule cells. in The international journal of biochemistry & cell biology 2012 (PubMed)

More Proteins for Chloride Channel 5 (CLCN5) Interaction Partners

Xenopus laevis Chloride Channel 5 (CLCN5) interaction partners

  1. analysis of extracellular determinants of anion discrimination of the Cl-/H+ antiporter protein CLC-5

Mouse (Murine) Chloride Channel 5 (CLCN5) interaction partners

  1. This study demonistrated that Clcn5 gene expression in mouse dorsal raphe nucleus

  2. ClC-5 plays an essential role in exocytosis of NHE3 (show SLC9A3 Proteins).

  3. HNF1alpha (show HNF1A Proteins) directly regulates the expression of ClC-5 in the renal proximal tubule

  4. ClC-5 is unique among CLC (show CLC Proteins) proteins in being crucial for proximal tubular endocytosis and the PY-motif-dependent ubiquitylation of ClC-5 is dispensable for this rol

  5. findings show that endosomal chloride concentration, which is raised by ClC-5 in exchange for protons accumulated by H+-ATPase (show ATP6AP1 Proteins), may play a role in endocytosis

  6. Our studies demonstrate a role for CLC-5 in the immunopathogenesis of ulcerative colitis

  7. ClC-5 regulates dentin development through TGF-beta1 (show TGFB1 Proteins) pathway

  8. Disruption of CLC-5 expression causes abnormal calcium crystal agglomeration on the surface of kidney collecting duct cells.

  9. hypercalciuria in the ClC-5 KO mice on low and high calcium diets is of bone and renal origin and is not caused by increased intestinal calcium absorption

  10. Impaired protein endocytosis caused by invalidation of ClC-5 primarily reflects a trafficking defect of megalin (show LRP2 Proteins) and cubilin (show CUBN Proteins) in PTC (show PTCH1 Proteins).

Human Chloride Channel 5 (CLCN5) interaction partners

  1. we carefully investigated the functional effects of four CLC-5 mutations, including three missense mutations (S244L, R345W, T657S) and one nonsense mutation (Q629X)

  2. A novel mutation in the CLCN5 gene was identified in our patient with Dent's disease.

  3. structural complexity of the CLCN5 5'UTR region

  4. ATP induces conformational changes in the carboxyl-terminal region of ClC-5.

  5. study described a single Chinese family with Dent disease, and findings suggest that a novel frameshift mutation (c. 246delG) in exon 5 of the CLCN5 gene was responsible for Dent disease in this case

  6. Dent disease is caused by mutations in at least two genes, i.e. CLCN5 and OCRL1 (show OCRL Proteins), and its genetic background and phenotypes are common among European countries and the USA.

  7. Case Report: computer simulation analysis of CIC-5 missense mutations in Dent's disease.

  8. These results elucidate the biophysical properties of ClC-5 and contribute to the understanding of its physiological role.

  9. Certain misprocessing mutations in CLC-5 chloride channels alter intramolecular interactions within the full-length protein, ensuring that they do not elicit the unfolded protein response.

  10. Dent disease-causing CLC-5 mutations have differing effects on endosomal acidification and receptor-mediated endocytosis that may not be coupled.

Chloride Channel 5 (CLCN5) Protein Profile

Protein Summary

This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Chloride Channel 5 Proteins (CLCN5)

  • chloride channel 5 (CLCN5)
  • chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease) (CLCN5)
  • chloride channel 5 (clcn5-A)
  • chloride channel 5 (clcn5)
  • chloride channel 5 (Clcn5)
  • chloride channel, voltage-sensitive 5 (CLCN5)
  • chloride channel, voltage-sensitive 5 (Clcn5)
  • H(+)/Cl(-) exchange transporter 5-like (LOC100135502)
  • outwardly rectifying chloride channel (CLC-5)
  • 5430408K11Rik protein
  • ClC-5 protein
  • CLC5 protein
  • CLCK2 protein
  • CLCN3 protein
  • CLCN4 protein
  • Clcn5 protein
  • clcn5-A protein
  • D930009B12Rik protein
  • DENTS protein
  • DKFZp469O2315 protein
  • DXImx42e protein
  • hCIC-K2 protein
  • NPHL1 protein
  • NPHL2 protein
  • Sfc13 protein
  • T25545 protein
  • XLRH protein
  • XRN protein

Protein level used designations for Chloride Channel 5 Proteins (CLCN5)

chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease) , chloride channel protein 5 , chloride channel 5 , H(+)/Cl(-) exchange transporter 5-like , Chloride channel protein 5 , H(+)/Cl(-) exchange transporter 5 , chloride transporter ClC-5 , voltage-gated chloride ion channel CLCN5 , clC-5 , chloride channel CLC-5 , chloride channel CLCN5 , chloride channel Clc-5

GENE ID SPECIES
493644 Bos taurus
422285 Gallus gallus
491882 Canis lupus familiaris
394306 Xenopus laevis
694497 Macaca mulatta
734069 Xenopus (Silurana) tropicalis
100410688 Callithrix jacchus
100174406 Pongo abelii
100581324 Nomascus leucogenys
12728 Mus musculus
1184 Homo sapiens
25749 Rattus norvegicus
100008741 Oryctolagus cuniculus
100135502 Cavia porcellus
397263 Sus scrofa
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