Chloride Intracellular Channel 4 Proteins (CLIC4)

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Additionally we are shipping CLIC4 Antibodies (107) and CLIC4 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLIC4 25932 Q9Y696
CLIC4 83718 Q9Z0W7
CLIC4 29876 Q9QYB1
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Top CLIC4 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$345.35
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 2 to 3 Days
$481.25
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

CLIC4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

More Proteins for Chloride Intracellular Channel 4 (CLIC4) Interaction Partners

Human Chloride Intracellular Channel 4 (CLIC4) interaction partners

  1. CLIC4 and Ihh (show IHH Proteins) could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma.

  2. in malignant pleural mesothelioma, the gene expressions of CLIC3 (show CLIC3 Proteins) and CLIC4 were significantly increased compared to controls

  3. CLIC1 (show CLIC1 Proteins) and CLIC4 are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)

  4. CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility.

  5. CLIC4, ERp29 (show ERP29 Proteins), and Smac/DIABLO (show DIABLO Proteins) integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer.

  6. This study investigated the proteome modulated by oncogenic KRAS in immortalized airway epithelial cells.

  7. Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension.

  8. CLIC4 increases tumor cell migration and invasion in a TGF-beta (show TGFB1 Proteins)-dependent manner.

  9. In addition to CLIC1 (show CLIC1 Proteins) and TPM1 (show TPM1 Proteins), which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2 (show TPM2 Proteins), TPM3 (show TPM3 Proteins), and TPM4 (show TPM4 Proteins) were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

  10. Our data indicate that CLIC4 protein may be a key element in the apoptotic response to oxidative stress.

Mouse (Murine) Chloride Intracellular Channel 4 (CLIC4) interaction partners

  1. Data, including data from studies in primary cells from knockout mice, suggest Clic1 (show CLIC1 Proteins) and Clic4 participate in signaling interleukin 1beta secretion and in activation of Nlrp3 (show NLRP3 Proteins) inflammasomes; in LPS (show TLR4 Proteins) macrophage activation, Clic1 (show CLIC1 Proteins) and Clic4 are translocated to nucleus/cell membranes. (Clic1 (show CLIC1 Proteins) = chloride intracellular channel 1 (show CLIC1 Proteins); Clic4 = chloride intracellular channel 4, mitochondrial; Nlrp3 (show NLRP3 Proteins) = NLR family pyrin domain containing 3 (show NLRP3 Proteins))

  2. study reports an alternately-spliced form of Smad7 (show SMAD7 Proteins), Smad7Delta, that is induced by TGF-beta (show TGFB1 Proteins) and CLIC4, is a dominant inhibitor of Smad7 (show SMAD7 Proteins) and enhances TGF-beta (show TGFB1 Proteins) signaling

  3. The findings indicate that CLIC4/CLIC5A-mediated ERM (show ETV5 Proteins) activation is required for maintenance of the glomerular capillary architecture.

  4. CLIC4 is not required for collaterogenesis but is essential for perinatal maturation of nascent collaterals through a mechanism that supports VEGF signaling.

  5. However, the absence of CLIC4 has no significant impact on the extent of functional recovery or fibrosis following acute injury.

  6. Data suggest that compartmentalized expression of chloride intracellular channel 4 (CLIC4) in specific adult tissues and cells provides a focus to explore potential functions of this protein.

  7. Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension.

  8. These results indicate that CLIC4 participates in skin healing and corneal wound reepithelialization through enhancement of epithelial migration by a mechanism that may involve a compromised TGF-beta (show TGFB1 Proteins) pathway.

  9. Data suggest that iNOS (show NOS2 Proteins)-induced nuclear CLIC4 is an essential part of the macrophage deactivation program.

  10. CLIC4 is required for an optimal macrophage response to diverse pathogens. CLIC4-null these findings suggest that CLIC4 is an LPS (show TLR4 Proteins)-induced product that can serve as a positive regulator of LPS (show TLR4 Proteins) signaling

CLIC4 Protein Profile

Protein Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family\; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).

Gene names and symbols associated with CLIC4

  • chloride intracellular channel 4 (clic4)
  • chloride intracellular channel 4 (TEgg069b11.1)
  • chloride intracellular channel 4 (CLIC4)
  • chloride intracellular channel 4 (Clic4)
  • chloride intracellular channel 4 (mitochondrial) (Clic4)
  • cb142 protein
  • CLIC4 protein
  • CLIC4L protein
  • D0Jmb3 protein
  • DKFZp459A0325 protein
  • H1 protein
  • huH1 protein
  • mc3s5 protein
  • MGC79614 protein
  • MGC89006 protein
  • mtCLIC protein
  • p64H1 protein
  • TU-74 protein
  • wu:fb33c05 protein
  • wu:fc30h10 protein
  • xclic4 protein

Protein level used designations for CLIC4

chloride intracellular channel 4 , Chloride intracellular channel protein 4 , chloride intracellular channel protein 4 , chloride intracellular channel 4 like , intracellular chloride ion channel protein p64H1 , chloride intracellular channel 4 (mitochondrial) , mitochondrial chloride intracellular channel 4 , mc3s5/mtCLIC

GENE ID SPECIES
448566 Xenopus (Silurana) tropicalis
493290 Xenopus (Silurana) tropicalis
712337 Macaca mulatta
749398 Pan troglodytes
100169733 Pongo abelii
100528919 Ictalurus punctatus
399410 Xenopus laevis
25932 Homo sapiens
487367 Canis lupus familiaris
286823 Bos taurus
83718 Rattus norvegicus
368255 Danio rerio
419595 Gallus gallus
29876 Mus musculus
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