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The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Additionally we are shipping Choline Kinase alpha Antibodies (56) and Choline Kinase alpha Kits (5) and many more products for this protein.
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These data also support the approach of antitumor strategies that destabilize Chk-alpha protein or downregulate PtdCho in breast cancer treatment.
Downregulation of choline kinase-alpha enhances autophagy in tamoxifen-resistant breast cancer cells.
CHKA can act as an AR chaperone, providing, to our knowledge, the first evidence for kinases as molecular chaperones, making CHKA both a marker of tumor progression and a potential therapeutic target for PCa (show FLVCR1 Proteins).
Identify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.
choline kinase alpha is inhibited by a near-infrared fluorescent carbocyanine
Increased expression of CHKA is seen in malignant lesions of prostate cancer
Chokalpha possessed oncogenic activity and could be a potential therapeutic target in T-cell lymphoma , as well as other hematological malignancies with interrupted Ras signaling pathways
Downregulation of Chk-alpha with siRNA increased PLD1 expression, and downregulation of PLD1 increased Chk-alpha expression.
The significance of CHKA overexpression on a TMA.
Our data suggest that choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells.
hepatic phosphatidylcholine (show SGMS2 Proteins) is regulated by the circadian clock through a Bmal1 (show ARNTL Proteins)-Rev-erbalpha (show NR1D1 Proteins)-Chkalpha axis
Enforced expression of either CK(alpha) or CCTalpha (show PCYT1A Proteins) increased the rate of synthesis and the amount of PtdCho, and these cells initiated neuronal differentiation.
Lack of muscle degeneration in forelimbs of Chkb (show CHKB Proteins)(-/-) mice is due to abundant choline kinase alpha and the stable homeostasis of phosphatidylcholine (show SGMS2 Proteins).
Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex.
ChoK may have a role in carcinogenesis
Data suggest that the choline kinase alpha promoter has a distal element (-875/-867) that binds c-jun (show JUN Proteins) and the binding of c-jun (show JUN Proteins) is enhanced by treatment with CCl4 (show CCL4 Proteins).
Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine (show SGMS2 Proteins).
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.
choline kinase alpha
, choline kinase beta
, choline kinase
, ethanolamine kinase
, choline/ethanolamine kinase alpha
, choline kinase R