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Cholinergic Receptor, Muscarinic 2 Proteins (CHRM2)

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. Additionally we are shipping Muscarinic Acetylcholine Receptor M2 Antibodies (127) and Muscarinic Acetylcholine Receptor M2 Kits (53) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CHRM2 CHRM2 81645 P10980
CHRM2 1129 P08172
CHRM2 243764 Q9ERZ4
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Top Muscarinic Acetylcholine Receptor M2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

CHRM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Cholinergic Receptor, Muscarinic 2 (CHRM2) Interaction Partners

Zebrafish Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. cloning, characterization and expression patterns; results suggest that the M2 mAChR (show CHRM3 Proteins) inhibits basal heart rate in zebrafish embryo and mediates carbachol-induced bradycardia

  2. The M(2) muscarinic receptor (show CHRM5 Proteins) plays a specific role in the initiation of hypoxic bradycardia in fish.

Human Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Report a significant association between CHRM2 (rs1824024) polymorphism and disease severity, lower lung function test values, frequent exacerbations, and poor response to anti-cholinergic drugs in COPD (show ARCN1 Proteins) patients.

  2. Inactivation of M2 AChR/NF-kappaB (show NFKB1 Proteins) signaling axis reverses epithelial-mesenchymal transition and suppresses migration and invasion in non-small cell lung cancer.

  3. CHRM2 gene expression was dysregulated in the anterior cingulate of bipolar patients.

  4. This study demonstrated that CD4 (show CD4 Proteins)+ and CD8 (show CD8A Proteins)+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.

  5. The expressed the fusion proteins of the muscarinic acetylcholine receptor M2 subtype with a maltose-binding protein and various G protein alpha (show GNAO1 Proteins) subunits in Escherichia coli.

  6. CHRM2 but not CHRM1 (show CHRM1 Proteins) or CHRM3 (show CHRM3 Proteins) polymorphisms are associated with asthma susceptibility in Mexican patients.

  7. High Muscarinic Receptor M2 expression is associated with peripartum cardiomyopathy.

  8. [(3)H]LY2119620 to probe specifically the human M2 and M4 muscarinic receptor (show CHRM5 Proteins) allosteric binding sites.

  9. The present report found an association between genetic variation of the CHRM2 rs1824024 SNP in the 8-12 year old group and not in the older age groups.

  10. This novel study demonstrated for the first time a full-scale screening of the proteomics research by CHRM2-C722G mutation and profiled 102 changed proteins, of which, eight might be critical in cardiac dysfunction

Pig (Porcine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp (show CLASRP Proteins) and sling fibers similar to human clasp (show CLASRP Proteins) and sling fibers.

Cow (Bovine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM (show KRIT1 Proteins)-activated plasma membrane-bound PDE1A (show PDE1A Proteins), linked to M(2)AChR.

  2. airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C/protein kinase C pathway

Rabbit Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Data suggest that autoantibodies to beta-1 adrenergic receptor (ADRB1 (show ADRB1 Proteins)) and muscarinic receptor M2 (CHRM2), along with elevated thyroxine (T4) levels, contribute to atrial tachyarrhythmia in Graves disease (GD); here, a rabbit model of GD is studied.

Mouse (Murine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Muscarinic M2 receptors in the circular muscular layer of mouse ileum exert a previously undocumented function in gut (show GUSB Proteins) motility via the regulation of gap junctions

  2. IL-17 (show IL17A Proteins) production in the hearts of M2AChR mice is dependent on P2x7 (show P2RX7 Proteins) expression in dilated cardiomyopathy.

  3. Expression of the M2 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS Proteins)-/- males and females, although only males exhibited a urinary phenotype.

  4. These results demonstrate that M2R are dysfunctional and do not affect ACh (show FGFR3 Proteins) levels in PRiMA (show PRIMA1 Proteins) knockout mice, likely because of down-regulation and/or loss of receptor-effector coupling.

  5. Data indicate taht m2R-RGS6 (show RGS6 Proteins)-IKACh pathway sets heart rate variability independently from the autonomic input.

  6. M2-mediated contractions in the M3KO and WT strains were decreased by the Rho kinase (show ROCK2 Proteins) (ROCK) inhibitor Y27632 as well as the ROCK, PKA and PKG (show PRKG1 Proteins) inhibitor H89.

  7. M2 receptor is co-localized with VGLUT2 on intraganglionic laminar endings of esophagus.

  8. Presence of M2 mAChR (show CHRM3 Proteins) is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.

  9. This study demonstrated that cholinergic projections recruit M(2) receptors to redistribute the gain of LTP (show SCP2 Proteins) in CA3 (show CA3 Proteins) pyramidal cells in an input-specific manner

  10. The function of M2 MR is substituted by beta3-AR and that these effects are mediated via adenylyl cyclase rather than NOS.

Muscarinic Acetylcholine Receptor M2 (CHRM2) Protein Profile

Protein Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with CHRM2

  • cholinergic receptor, muscarinic 2a (chrm2a)
  • cholinergic receptor, muscarinic 2 (LOC100220676)
  • cholinergic receptor, muscarinic 2 (LOC100231098)
  • cholinergic receptor, muscarinic 2 (CHRM2)
  • cholinergic receptor, muscarinic 2 (Chrm2)
  • cholinergic receptor, muscarinic 2, cardiac (Chrm2)
  • AChR-M2 protein
  • Acm2 protein
  • Chrm-2 protein
  • chrm2 protein
  • GPM2 protein
  • HM2 protein
  • M2 protein

Protein level used designations for CHRM2

muscarinic acetylcholine receptor M2 , cholinergic receptor, muscarinic 2 , muscarinic acetylcholine receptor M2-like , 7TM receptor , M2 muscarinic acetylcholine receptor , cholinergic receptor, muscarinic 2, cardiac , muscarinic receptor m2 , acetylcholine receptor, muscarinic 2 , muscarinic M2 receptor , cardiac muscarinic acetylcholine receptor , m2 muscarinic acetylcholine receptor , muscarinic acetylcholine receptor m2 , cholinergic receptor muscarinic 2 , muscarinic receptor 2 , Muscarinic acetylcholine receptor M2 , AChR M2 , muscarinic acetylcholine receptor 2

GENE ID SPECIES
352938 Danio rerio
100220676 Taeniopygia guttata
100231098 Taeniopygia guttata
100411083 Callithrix jacchus
100450243 Pongo abelii
100593190 Nomascus leucogenys
100628317 Ovis aries
81645 Rattus norvegicus
1129 Homo sapiens
397498 Sus scrofa
418126 Gallus gallus
403858 Canis lupus familiaris
522170 Bos taurus
100342878 Oryctolagus cuniculus
100715343 Cavia porcellus
101102897 Ovis aries
463758 Pan troglodytes
243764 Mus musculus
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