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Cholinergic Receptor, Muscarinic 4 Proteins (CHRM4)

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. Additionally we are shipping Cholinergic Receptor, Muscarinic 4 Antibodies (38) and Cholinergic Receptor, Muscarinic 4 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CHRM4 CHRM4 25111 P08485
CHRM4 1132 P08173
CHRM4 12672 P32211
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Top Cholinergic Receptor, Muscarinic 4 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,256.83
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

CHRM4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,
,

More Proteins for Cholinergic Receptor, Muscarinic 4 (CHRM4) Interaction Partners

Human Cholinergic Receptor, Muscarinic 4 (CHRM4) interaction partners

  1. This study demonstrated that CD4 (show CD4 Proteins)+ and CD8 (show CD8A Proteins)+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.

  2. [(3)H]LY2119620 to probe specifically the human M2 and M4 muscarinic receptor (show CHRM5 Proteins) allosteric binding sites.

  3. Data indicate that compounds derived from VU0152100 showed M4 muscarinic receptor (show CHRM5 Proteins) (M4 mAChR (show CHRM3 Proteins)) direct agoinst properties.

  4. Use of HM4- and green fluorescent protein-expressing trangenic mice as tissue donors in cell-based therapy validates a rodent model of Huntington disease (show HTT Proteins).

  5. analysis of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor

  6. relative to other muscarinic receptor (show CHRM5 Proteins) subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease

  7. M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP (show APRT Proteins)-protein kinase A pathway

  8. In progressive supranuclear palsy: there were no changes in M4 muscarinic receptor (show CHRM5 Proteins) density

Mouse (Murine) Cholinergic Receptor, Muscarinic 4 (CHRM4) interaction partners

  1. Muscarinic acetylcholine receptor (show CHRNB1 Proteins) subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin (show SST Proteins)

  2. We show that M4 is a major mAChR (show CHRM3 Proteins) subtype mediating the cholinergic inhibition of corticostriatal glutamatergic input on both striatonigral and striatopallidal medium spiny neurons (MSNs).

  3. Presence of M4 mAChR (show CHRM3 Proteins) is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.

  4. M4R is involved in regulation of locomotor activity, social behavior, and sensorimotor gating in mice.

  5. Reducing M4 receptor signaling altered only select behavioral phenotypes in the Fmr1KO mouse model, suggesting that other targets are involved in the modulation of fragile X (show FMR1 Proteins) behaviors.

  6. Chrm4 receptor is located on presynaptic glutamatergic terminals afferent to the recorded pyramidal neuron, thus decreasing glutamate (show GRIN1 Proteins) release.

  7. Different coupling of striatal M(2)/M (show RPS26 Proteins)(4)-mAChRs to the control of DA release in CPu versus NAc suggests targets to influence DA/ACh (show FGFR3 Proteins) function differentially between striatal domains.

  8. M(4) mAChR (show CHRM3 Proteins) plays a central role in mediating cholinergic control of keratinocyte migration by endogenous acetylcholine produced by these cells

  9. loss of M4 muscarinic receptor (show CHRM5 Proteins) control of cholinergic function effectuates a state of dopaminergic hyperexcitability

  10. M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP (show TMPRSS5 Proteins)-protein kinase A pathway

Cholinergic Receptor, Muscarinic 4 (CHRM4) Protein Profile

Protein Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown\; however, mouse studies link its function to adenylyl cyclase inhibition.

Gene names and symbols associated with CHRM4

  • cholinergic receptor, muscarinic 4 (CHRM4)
  • cholinergic receptor, muscarinic 4 (chrm4)
  • cholinergic receptor, muscarinic 4 (LOC100220023)
  • cholinergic receptor, muscarinic 4 (Chrm4)
  • Chrm-4 protein
  • HM4 protein
  • M3R protein
  • M4 protein
  • M4R protein

Protein level used designations for CHRM4

muscarinic acetylcholine receptor M4 , muscarinic acetylcholine receptor subtype 3 , cholinergic receptor, muscarinic 4 , cholinergic receptor, muscarin 4 , acetylcholine receptor, muscarinic 4 , AChR M4 , mm4 mAChR , muscarinic acetylcholine receptor 4 , muscarinic receptor, M4 subtype , Muscarinic acetylcholine receptor M4

GENE ID SPECIES
574195 Macaca mulatta
611314 Canis lupus familiaris
466504 Pan troglodytes
100127705 Xenopus (Silurana) tropicalis
100220023 Taeniopygia guttata
25111 Rattus norvegicus
1132 Homo sapiens
12672 Mus musculus
512928 Bos taurus
423195 Gallus gallus
100337585 Xenopus laevis
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