Cholinergic Receptor, Nicotinic, alpha 6 (Neuronal) Proteins (CHRNA6)

CHRNA6 encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. Additionally we are shipping CHRNA6 Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CHRNA6 CHRNA6 81721 P43143
CHRNA6 11440 Q9R0W9
CHRNA6 8973 Q15825
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Top CHRNA6 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$388.93
Details

CHRNA6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Cholinergic Receptor, Nicotinic, alpha 6 (Neuronal) (CHRNA6) Interaction Partners

Human Cholinergic Receptor, Nicotinic, alpha 6 (Neuronal) (CHRNA6) interaction partners

  1. More low frequency variants in the CHRNA6/CHRNB3 gene region were observed in cases compared to controls.

  2. Chrna6 has a cellular expression signature for retinal ganglion cells with high correlation to Thy1, a known marker. Immunofluorescence confirms this gene is preferentially expressed by RGCs in the young and adult mouse retina and expression is reduced in glaucoma.

  3. the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.

  4. Polymorphism in CHRNA6 gene is associated with esophageal adenocarcinoma.

  5. The common variant rs13273442 in the CHRNB3 (show CHRNB3 Proteins)-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans.

  6. these results demonstrate that the combined effect of rs6474412-C/T polymorphism in smoking-related CHRNB3-CHRNA6 region gene and smoking behavior may not confer risk to psoriasis vulgaris (PV), but may have impact on PV severity in Chinese Han population.

  7. findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers

  8. Results demonstrate the association between SNPs in CHRNA6 nicotinic acetylcholine receptor genes and the risk of smoking in ADHD

  9. Cross sectional data of US adults from the NHANES linked with genotype and geocodes were used to identify tobacco use phenotypes, state-level taxation rates, and variation in the nicotinic acetylcholine receptor (CHRNA6) genotype

  10. beta3 subunit coexpression promotes function of alpha6*-nAChR

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 6 (Neuronal) (CHRNA6) interaction partners

  1. Using behavioral and cellular measures of alpha6 * nAChR function, study demonstrated that the ventral tegmental area is a key site of action for nicotine at alpha6 * nAChRs

  2. these data indicate that a6)nAChR (show CHRNA4 Proteins) do not have an impact on motor output.

  3. enhanced alpha6beta2* nAChR (show CHRNA4 Proteins) activity in nucleus accumbens can stimulate dopamine production

  4. Chrna6 expression decreases with death of RGCs in glaucomatous DBA/2J mice and after optic nerve crush injury, further supporting Chrna6 as a reliable RGC marker.

  5. While the Chrna6 gene did not significantly influence ethanol consumption (g/kg) or ataxia (show USP14 Proteins), mice lacking the alpha6 subunit took significantly longer to recover their righting reflex than WT animals

  6. beta3 subunit coexpression promotes function of alpha6*-nAChR

  7. analysis of N-terminal extracellular domain determinants in nicotinic acetylcholine receptor (nAChR (show CHRNA4 Proteins)) alpha6 subunits that influence effects of wild-type or mutant beta3 subunits on function of alpha6beta2*- or alpha6beta4*-nAChR (show CHRNA4 Proteins)

  8. Data show that in Prkce (show PRKCE Proteins)(-/-) mice, conditioned place preference and self-administer behaviors are associated with reduced levels of alpha(6) and beta(3) nicotinic receptor subunit mRNA in the ventral midbrain and striatum.

CHRNA6 Protein Profile

Protein Summary

This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence.

Gene names and symbols associated with CHRNA6

  • cholinergic receptor, nicotinic, alpha 6 (neuronal) (Chrna6)
  • cholinergic receptor, nicotinic, alpha 6 (CHRNA6)
  • cholinergic receptor, nicotinic, alpha 6 (neuronal) (CHRNA6)
  • cholinergic receptor, nicotinic, alpha polypeptide 6 (Chrna6)
  • cholinergic receptor, nicotinic, alpha 6 (chrna6)
  • Acra6 protein
  • CHNRA6 protein
  • Nica6 protein
  • si:dkey-234d14.1 protein

Protein level used designations for CHRNA6

cholinergic receptor, nicotinic, alpha polypeptide 6 , neuronal acetylcholine receptor subunit alpha-6 , alpha 6 nicotinic acetylcholine receptor subunit , acetylcholine receptor alpha 6 neural , alpha6 nAChR , nicotinic acetylcholine receptor subunit alpha 6 , neuronal acetylcholine receptor protein, alpha-6 subunit , neuronal nicotinic acetylcholine receptor alpha 6 , acetylcholine receptor, nicotinic, alpha 6 (neuronal) , cholinergic receptor, nicotinic, alpha 6 , neuronal acetylcholine receptor subunit alpha-6-like

GENE ID SPECIES
81721 Rattus norvegicus
396321 Gallus gallus
482836 Canis lupus familiaris
539113 Bos taurus
11440 Mus musculus
472750 Pan troglodytes
555747 Danio rerio
8973 Homo sapiens
705725 Macaca mulatta
100033042 Monodelphis domestica
100049908 Equus caballus
100355656 Oryctolagus cuniculus
100399236 Callithrix jacchus
100445583 Pongo abelii
100470009 Ailuropoda melanoleuca
100591999 Nomascus leucogenys
100622106 Sus scrofa
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