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Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) Proteins (CHRNA7)

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Additionally we are shipping CHRNA7 Antibodies (67) and CHRNA7 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHRNA7 1139 P36544
CHRNA7 25302 Q05941
CHRNA7 11441 P49582
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Top CHRNA7 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

CHRNA7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)
Mouse (Murine) ,
,

Top referenced CHRNA7 Proteins

  1. Human CHRNA7 Protein expressed in Wheat germ - ABIN1349406 : Chandley, Miller, Kwasigroch, Wilson, Miller: Increased antibodies for the alpha7 subunit of the nicotinic receptor in schizophrenia. in Schizophrenia research 2009 (PubMed)

More Proteins for Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) Interaction Partners

Cow (Bovine) Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor

  2. Loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly of the alpha7 nicotinic receptor.

  3. a network of interactions formed by residues Lys (show LYZ Proteins)-46, Asp (show ASIP Proteins)-128, Asp (show ASIP Proteins)-135, Asp (show ASIP Proteins)-266, and possibly others appears to link agonist binding to channel gating

Human Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. This review discusses the current literature on stroke-induced inflammation and the effects of CHRNA7 modulators on innate immune cells.[Review]

  2. Promoter variant -194C (rs28531779) was significantly associated with schizophrenia, but not associated with P50 suppression or pre-pulse inhibition of the startle reflex. CHRNA7 promoter variants had elevated startle magnitude in pulse-alone trials.

  3. This supports the hypothesis that the antiproliferative activity of SLURP-1 (show SLURP1 Proteins) is related to 'metabotropic' signaling pathway through alpha7-nAChR, that activates intracellular signaling cascades without opening the receptor channel.

  4. expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs

  5. 14 single nucleotide polymorphisms cause missense mutations of human alpha7 nicotinic receptor exert a different functional impact.

  6. It was concluded that the mechanism of alpha-bungarotoxin antagonism of CHRNA7 is non-competitive, originating from conformational arrest of the binding sites.

  7. The CNV-3956 of CHRNA7 contributed to increased risks and poor prognoses of both COPD (show ARCN1 Proteins) and lung cancer, and this may be a genetic biomarker of the two diseases.

  8. The results clearly showed that depletion of A7-nAChR (show CHRNA4 Proteins) suppressed the drug sensitivity of gastric cancer cells to 5-FU treatment

  9. Study explored the microscopic mechanisms underlying the interplay between the channel domains and the coupling interface that affect the channel activity, and generated an allosteric gating model for CHRNA7

  10. Data show preferential fetal CHRFAM7A expression in the human prefrontal cortex and suggest abnormalities in the CHRFAM7A/CHRNA7 ratios in schizophrenia and bipolar disorder, due mainly to overexpression of CHRFAM7A.

Pig (Porcine) Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. Results suggest that a nearly similar TBI (show TBPL1 Proteins)-induced decrease in the alpha7 density in the brain of immature and adult animals is found, even with the differences in species, age and experimental procedures.

Rhesus Monkey Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. Lynx1 (show LYNX1 Proteins) appears to act as a negative modulator of alpha7 nAChR-induced events by inhibiting Src (show SRC Proteins) activation.

  2. Chronic nicotine exposure up-regulates nAChR (show CHRNA4 Proteins) activity in developing lung, and that nAChR (show CHRNA4 Proteins) activity can be further modified by tyrosine phosphorylation.

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. It is concluded that inflammation decreases alpha7 nAChR expression in both mitochondria and cell plasma membrane and makes mitochondria more susceptible to apoptosis induction.

  2. Chrna7-deficient mice exhibit sustained attention impairments that are reversed by Chrnb2 activation

  3. The results of this study suggest that activators of nAChRa7 may have therapeutic utility for the treatment of Traumatic brain injury.

  4. Neuroprotective effect of cellular prion protein (PrPC (show PRNP Proteins)) is related with activation of alpha7 nicotinic acetylcholine receptor (alpha7nAchR)-mediated autophagy flux.

  5. results show that preincubation of 3T3-L1 cells with alpha7nAChR agonist GTS-21 significantly reduces ASP (show C3 Proteins)-mediated chemokine (show CCL1 Proteins) MCP-1 (show CPT1B Proteins) secretion

  6. cAMP-dependent protein kinase (show CDK7 Proteins) inhibits alpha7 nicotinic receptor activity in layer 1 cortical interneurons through activation of D1/D5 dopamine receptors

  7. we have described the impact of a point mutation in the nicotinic acetylcholine receptor alpha7 on the inflammatory response by the lung to intranasal LPS (show TLR4 Proteins)

  8. Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1 (show HRASLS Proteins), which defines a new signaling pathway employed by alpha7 nAChRs

  9. Cell surface localization of alpha7-nAChR in the brain of 5xFAD mouse, an animal model of Alzheimer's disease, increased in an age -dependent manner in association with increased accumulation of ABETA (show APP Proteins) 1-42 in the plasma membrane component.

  10. Chrna7 KO mice had significantly decreased blood-brain barrier injury from C. neoformans infection.

CHRNA7 Protein Profile

Protein Summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CHRNA7

  • cholinergic receptor, nicotinic, alpha 7 (CHRNA7)
  • cholinergic receptor, nicotinic, alpha 7 (neuronal) (CHRNA7)
  • cholinergic receptor, nicotinic, alpha 7 (neuronal) (Chrna7)
  • cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7)
  • Acra7 protein
  • alpha7 protein
  • BTX protein
  • CHRNA7-2 protein
  • nAChRa7 protein
  • NARAD protein

Protein level used designations for CHRNA7

alpha 7 nicotinic acetylcholine receptor , cholinergic receptor, nicotinic, alpha polypeptide 7 , neuronal acetylcholine receptor subunit alpha-7 , a7 nicotinic acetylcholine receptor , alpha 7 neuronal nicotinic acetylcholine receptor , alpha-7 nicotinic cholinergic receptor subunit , neuronal acetylcholine receptor protein, alpha-7 chain , cholinergic receptor nicotinic alpha 7 , C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha) , C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha) , bungarotoxin alpha , neuronal nicotinic acetycholine receptor alpha 7 , nicotinic receptor alpha 7 subunit , nicotinic acetylcholine receptor alpha7 , acetylcholine receptor alpha 7 neural , alpha7 nicotinic receptor , alpha7-nAChR

GENE ID SPECIES
282178 Bos taurus
1139 Homo sapiens
374001 Gallus gallus
100415931 Sus scrofa
25302 Rattus norvegicus
488696 Canis lupus familiaris
574230 Macaca mulatta
11441 Mus musculus
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