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Cholinergic Receptor, Nicotinic, epsilon (Muscle) Proteins (CHRNE)

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. Additionally we are shipping CHRNE Antibodies (42) and CHRNE Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHRNE 1145 Q04844
Rat CHRNE CHRNE 29422 P09660
CHRNE 11448 P20782
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Top CHRNE Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CHRNE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) Interaction Partners

Human Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) interaction partners

  1. mutational analysis of CHRNE revealed a homozygous 1293insG, which is a well-known low-expressor receptor mutation in patients with epidermolysis bullosa simplex and congenital myasthenic syndrome.

  2. Three siblings have a clinical history and examination findings typical of homozygous CHRNE mutations; clinical presentation of congenital myasthenia subtypes is variable, and accurate genotyping is essential in choosing appropriate treatment.

  3. Targeting nAChR (show CHRNA4 Proteins) could offer a strategy for reducing neurodegeneration secondary to hyperphosphorylation of protein tau (show YWHAQ Proteins).

  4. The mutations in the varepsilon subunit altered Ca(2 (show CA2 Proteins)+) permeability of AChR-channels, with varepsilon(L269F) increasing P(f) and varepsilon(I257F) decreasing it.

  5. analysis of symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating

  6. two binding sites differ by roughly 10-fold in the affinity of the shut receptor for ACh (show FGFR3 Proteins) in the wild type, and that in the epsilonL221F mutation the lower affinity is increased so the sites become more similar.

  7. There was deletion in exon 7 of CHRNE. We cloned the entire CHRNE spanning 12 exons and 11 introns and expressed it in COS cells

  8. It was found that mutations within muscle AChRs are the most common cause of CMS (show Cd2ap Proteins). The majority are located within the epsilon-subunit gene and result in AChR deficiency.

  9. AChR epsilon-chain peptides are tested for their in vitro ability to activate peripheral blood mononuclear leukocytes of myasthenia gravis (MG) patients; MG patient cells are stimulated, whereas cells from nonmyasthenic subjects do not respond.

  10. Reported is a patient with a congenital myasthenic syndrome due to two compound heterozygous mutations of the CHRNE gene. T

Cow (Bovine) Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) interaction partners

  1. To elucidate the genetic defect in four previously reported related Brahman calves with severe myasthenic weakness, we determined the genomic structure of the gene encoding the bovine epsilon-subunit (bovCHRNE) of the acetylcholine receptor (AChR).

  2. It was found that mutations within muscle AChRs are the most common cause of CMS (show Cd2ap Proteins). The majority are located within the epsilon-subunit gene and result in AChR deficiency.

  3. Genotyping of the South African, registered, Brahman cattle population for the 470del20 mutation in the CHRNE gene causing congenital myasthenic syndrome is reported.

Mouse (Murine) Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) interaction partners

  1. a pattern of histone modifications associated with transcriptional activation is targeted to the AChR epsilon subunit locus in myotubes prior to stimulation

  2. analysis of symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating

  3. CDK2 (show CDK2 Proteins) is an intermediate molecule that integrates neuregulin-activated signals from both the MAPK (show MAPK1 Proteins) and PI3K pathways to AChRepsilon expression

  4. In L221F, T264P, L269F mutants the peak-current amplitude decreases along trains of nearly saturating ACh (show FGFR3 Proteins) pulses delivered at physiologically relevant frequencies, consistent with enhanced entry into desensitization in congenital myasthenic syndrome.

CHRNE Protein Profile

Protein Summary

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.

Gene names and symbols associated with CHRNE

  • cholinergic receptor, nicotinic, epsilon (muscle) (CHRNE)
  • cholinergic receptor, nicotinic, epsilon (muscle) (Chrne)
  • cholinergic receptor, nicotinic, epsilon (muscle) (chrne)
  • cholinergic receptor, nicotinic, epsilon polypeptide (Chrne)
  • ACHRE protein
  • AChrepsilon protein
  • Acre protein
  • CMS1D protein
  • CMS1E protein
  • CMS2A protein
  • FCCMS protein
  • nAChRE protein
  • SCCMS protein

Protein level used designations for CHRNE

AchR epsilon subunit , acetylcholine receptor subunit epsilon , acetylcholine receptor, nicotinic, epsilon (muscle) , cholinergic receptor, nicotinic, epsilon polypeptide , acetylcholine receptor epsilon , epsilon-subunit , gene for acetylcholine receptor epsilon subunit , nicotinic acetylcholine receptor epsilon subunit

GENE ID SPECIES
1145 Homo sapiens
281688 Bos taurus
29422 Rattus norvegicus
386670 Xenopus laevis
11448 Mus musculus
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