anti-Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) Antibodies

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. Additionally we are shipping CHRNE Kits (12) and CHRNE Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHRNE 1145 Q04844
CHRNE 29422 P09660
CHRNE 11448 P20782
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Top anti-CHRNE Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Guinea Pig Rabbit Un-conjugated WB <b>WB Suggested Anti-CHRNE Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$221.76
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$326.89
Details
Cow Goat Un-conjugated WB Staining of Mouse Fetal Skeletal Muscle lysate using ACHRE / CHRNE Antibody at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using CHRNE antibody. 100 μL Log in to see 16 Days
$323.13
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$446.88
Details
Cow Goat Un-conjugated ELISA, WB ABIN2560905 (1µg/ml) staining of Mouse Fetal Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μL Log in to see 16 Days
$430.08
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
$507.83
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$221.76
Details

CHRNE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus) ,
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Mouse (Murine) ,
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More Antibodies against CHRNE Interaction Partners

Human Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) interaction partners

  1. mutational analysis of CHRNE revealed a homozygous 1293insG, which is a well-known low-expressor receptor mutation in patients with epidermolysis bullosa simplex and congenital myasthenic syndrome.

  2. Three siblings have a clinical history and examination findings typical of homozygous CHRNE mutations; clinical presentation of congenital myasthenia subtypes is variable, and accurate genotyping is essential in choosing appropriate treatment.

  3. Targeting nAChR (show CHRNA4 Antibodies) could offer a strategy for reducing neurodegeneration secondary to hyperphosphorylation of protein tau (show YWHAQ Antibodies).

  4. The mutations in the varepsilon subunit altered Ca(2 (show CA2 Antibodies)+) permeability of AChR-channels, with varepsilon(L269F) increasing P(f) and varepsilon(I257F) decreasing it.

  5. analysis of symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor (show CHRNA1 Antibodies) channel gating

  6. two binding sites differ by roughly 10-fold in the affinity of the shut receptor for ACh (show FGFR3 Antibodies) in the wild type, and that in the epsilonL221F mutation the lower affinity is increased so the sites become more similar.

  7. There was deletion in exon 7 of CHRNE. We cloned the entire CHRNE spanning 12 exons and 11 introns and expressed it in COS cells

  8. It was found that mutations within muscle AChRs are the most common cause of CMS (show Cd2ap Antibodies). The majority are located within the epsilon-subunit gene and result in AChR deficiency.

  9. AChR epsilon-chain peptides are tested for their in vitro ability to activate peripheral blood mononuclear leukocytes of myasthenia gravis (MG) patients; MG patient cells are stimulated, whereas cells from nonmyasthenic subjects do not respond.

  10. Reported is a patient with a congenital myasthenic syndrome due to two compound heterozygous mutations of the CHRNE gene. T

Mouse (Murine) Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) interaction partners

  1. a pattern of histone modifications associated with transcriptional activation is targeted to the AChR epsilon subunit locus in myotubes prior to stimulation

  2. analysis of symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor (show CHRNB1 Antibodies) channel gating

  3. CDK2 (show CDK2 Antibodies) is an intermediate molecule that integrates neuregulin-activated signals from both the MAPK (show MAPK1 Antibodies) and PI3K pathways to AChRepsilon expression

  4. In L221F, T264P, L269F mutants the peak-current amplitude decreases along trains of nearly saturating ACh (show FGFR3 Antibodies) pulses delivered at physiologically relevant frequencies, consistent with enhanced entry into desensitization in congenital myasthenic syndrome.

Cow (Bovine) Cholinergic Receptor, Nicotinic, epsilon (Muscle) (CHRNE) interaction partners

  1. To elucidate the genetic defect in four previously reported related Brahman calves with severe myasthenic weakness, we determined the genomic structure of the gene encoding the bovine epsilon-subunit (bovCHRNE) of the acetylcholine receptor (show CHRNB1 Antibodies) (AChR).

  2. It was found that mutations within muscle AChRs are the most common cause of CMS (show Cd2ap Antibodies). The majority are located within the epsilon-subunit gene and result in AChR deficiency.

  3. Genotyping of the South African, registered, Brahman cattle population for the 470del20 mutation in the CHRNE gene causing congenital myasthenic syndrome is reported.

CHRNE Antigen Profile

Protein Summary

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.

Gene names and symbols associated with CHRNE

  • cholinergic receptor, nicotinic, epsilon (muscle) (CHRNE) antibody
  • cholinergic receptor, nicotinic, epsilon (muscle) (Chrne) antibody
  • cholinergic receptor, nicotinic, epsilon polypeptide (Chrne) antibody
  • cholinergic receptor, nicotinic, epsilon (muscle) (chrne) antibody
  • cholinergic receptor, nicotinic, epsilon (chrne) antibody
  • cholinergic receptor, nicotinic, epsilon (CHRNE) antibody
  • ACHRE antibody
  • AChrepsilon antibody
  • Acre antibody
  • CHRNE antibody
  • CMS1D antibody
  • CMS1E antibody
  • CMS2A antibody
  • FCCMS antibody
  • im:7154697 antibody
  • nAChRE antibody
  • SCCMS antibody
  • zgc:101010 antibody

Protein level used designations for CHRNE

AchR epsilon subunit , acetylcholine receptor subunit epsilon , acetylcholine receptor, nicotinic, epsilon (muscle) , cholinergic receptor, nicotinic, epsilon polypeptide , acetylcholine receptor epsilon , epsilon-subunit , gene for acetylcholine receptor epsilon subunit , nicotinic acetylcholine receptor epsilon subunit , AChR epsilon , acetylcholine receptor subunit gamma , nicotinic acetylcholine receptor subunit epsilon , nicotinic acetylcholine receptor epsilon polypeptide , cholinergic receptor, nicotinic, epsilon , Acetylcholine receptor subunit epsilon , acetylcholine receptor subunit epsilon-like

GENE ID SPECIES
1145 Homo sapiens
29422 Rattus norvegicus
11448 Mus musculus
386670 Xenopus laevis
445315 Danio rerio
468165 Pan troglodytes
479471 Canis lupus familiaris
710301 Macaca mulatta
100391579 Callithrix jacchus
281688 Bos taurus
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