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Chromodomain Helicase DNA Binding Protein 4 Proteins (CHD4)

The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Antibodies (70) and CHD4 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHD4 1108 Q14839
Rat CHD4 CHD4 117535  
Mouse CHD4 CHD4 107932 Q6PDQ2
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Top CHD4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$534.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

CHD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Chromodomain Helicase DNA Binding Protein 4 (CHD4) Interaction Partners

Human Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD domain and MBD2 C-terminus.

  2. these data build on our understanding of how CHD4-NuRD acts to regulate gene expression and participates in the DNA-damage response.

  3. CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Proteins) cell genes that regulate tumor formation in vivo and colony formation in vitro.

  4. Also discovered a novel causative role for CHD4, a helicase involved in the histone deacetylase (show HDAC1 Proteins) complex that is associated with poor clinical outcome.

  5. CHD4 modulates therapeutic response in BRCA2 (show BRCA2 Proteins) mutant cancer cells.

  6. Endogenous Mta1 (show MTA1 Proteins)/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylases (Hdac)1 (show HDAC1 Proteins)/2, RbAp46 (show RBBP7 Proteins)/48, and Mbd3 (show MBD3 Proteins) in rat cerebellum

  7. CHD4 and HDAC1 (show HDAC1 Proteins) occupy the promoters of several of these hypermethylated tumor suppressor genes and physically and functionally interact to maintain their silencing.

  8. repressive functions of MBD2-containing NuRD complexes are dependent on cooperative interactions between the major domains of CHD4 with histones and DNA and on binding of methylated DNA by MBD2

  9. a three-dimensional structural model describing the overall shape and domain interactions of CHD4 and discuss the relevance of these for regulating the remodeling of chromatin by the NuRD complex.

  10. Concerted action of the PHD (show PDC Proteins), chromo and motor domains regulates the human chromatin remodelling ATPase CHD4

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Proteins) cell genes that regulate tumor formation in vivo and colony formation in vitro.

  2. CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.

  3. Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells

  4. Chd4, interacting with Hdac1 (show HDAC1 Proteins)/2, cooperates with its related proteins Kap1 (show TRIM28 Proteins) and Cbx1 (show CBX1 Proteins) to bind at -207/-148 of the Sox9 (show SOX9 Proteins) promoter.

  5. NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.

  6. The chromodomain helicase DNA-binding protein 4 (Chd4) is a critical interaction partner of Ezh2 (show EZH2 Proteins) required specifically for Polycomb (show CBX2 Proteins) group (PcG)-mediated suppression of the key astrogenic marker gene GFAP (show GFAP Proteins).

  7. Gata3 (show GATA3 Proteins)/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation.

  8. In this study, we demonstrate that Mi2beta is required for gamma-globin gene silencing during adult definitive erythropoiesis

  9. Concomitant deletion of Chd4 and Brg1 rescued vascular abnormalities seen in Brg1 mutant yolk sacs to the same extent as LiCl treatment.

  10. activity of the Mi-2beta nucleosome-remodeling and histone-deacetylase (show HDAC1 Proteins) (NuRD) complex was controlled by the Ikaros (show IKZF1 Proteins) family of lymphoid lineage-determining proteins.

Xenopus laevis Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.

CHD4 Protein Profile

Protein Summary

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Gene names and symbols associated with CHD4

  • chromodomain helicase DNA binding protein 4 (CHD4)
  • chromodomain helicase DNA binding protein 4a (chd4a)
  • chromodomain helicase DNA binding protein 4b (chd4b)
  • chromodomain helicase DNA binding protein 4 (chd4)
  • chromodomain helicase DNA binding protein 4 (Chd4)
  • 9530019N15Rik protein
  • AA617397 protein
  • b230399n07 protein
  • BC005710 protein
  • CHD4 protein
  • D6Ertd380e protein
  • im:7143343 protein
  • MGC145363 protein
  • Mi-2 protein
  • Mi-2b protein
  • Mi-2beta protein
  • Mi2-BETA protein
  • mKIAA4075 protein
  • si:ch211-51m24.3 protein
  • si:ch211-57k11.10 protein
  • wu:fb44b12 protein
  • wu:fd12d03 protein

Protein level used designations for CHD4

chromodomain helicase DNA binding protein 4 , chromodomain-helicase-DNA-binding protein 4 , ATP-dependent helicase CHD4 , CHD-4 , Mi-2 autoantigen 218 kDa protein , Mi-2 autoantigen , Mi-2 beta

GENE ID SPECIES
418278 Gallus gallus
451788 Pan troglodytes
558344 Danio rerio
560622 Danio rerio
100059817 Equus caballus
100124711 Xenopus (Silurana) tropicalis
100515610 Sus scrofa
100539798 Meleagris gallopavo
100566510 Anolis carolinensis
1108 Homo sapiens
117535 Rattus norvegicus
107932 Mus musculus
380196 Xenopus laevis
477714 Canis lupus familiaris
506402 Bos taurus
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