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May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.. Additionally we are shipping Chromosome 1 Open Reading Frame 38 Proteins (4) and many more products for this protein.
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SNP rs1467465 of the human gene icb-1 might affect susceptibility to ovarian cancer.
Loss of icb-1 expression accelerated proliferation of SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of ovarian cancer biomarkers like KLK10 (show KLK10 Antibodies) and CLDN16 (show CLDN16 Antibodies).
Data of this study suggest that icb-1 might exert a tumor-suppressor function in breast cancer and that its loss might confer relative resistance of breast cancer cells to apoptotic drugs.
Themis2 and Themis1 exhibit the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice.
These findings together with the observed co-expression of icb-1 with E-cadherin (show CDH1 Antibodies) in breast cancer samples support an important role of the icb-1 gene in cancer cell differentiation.
Data show that a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001).
Identification of ICB-1 as a new player in endocrine-related cancer.
Increased icb-1 mRNA levels could be observed both in monocytic and granulocytic differentiation in maturing HL-60 cells.
The novel interferon-gamma (show IFNG Antibodies) inducible gene icb-1 is identified and its effects on the response of ovarian cancer cells to interferon-gamma (show IFNG Antibodies) are described
Data suggest that SNP rs1467465 of human gene icb-1 might affect breast cancer susceptibility.
Data indicate that Themis2 protein is not required for B cell development, for activation, or for antibody responses either to model Ags (show GLA Antibodies) or to influenza viral infection.
Study hypothesise that Themis2 may constitute a novel, physiological control point in macrophage inflammatory responses.
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.
chromosome 1 open reading frame 38
, basement membrane-induced
, induced by contact to basement membrane 1 protein
, protein ICB-1
, protein THEMIS2
, thymocyte-expressed molecule involved in selection protein 2
, basement membrane-induced protein