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Acts as a specific nuclear import carrier for hsp70 nucleoporin-dependent translocation of ATP-bound hsp70 proteins into the nucleus. Additionally we are shipping C11orf73 Proteins (3) and many more products for this protein.
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Hamster Polyclonal C11orf73 Primary Antibody for EIA, FACS - ABIN950728
Need, Attix, McEvoy, Cirulli, Linney, Hunt, Ge, Heinzen, Maia, Shianna, Weale, Cherkas, Clement, Spector, Gibson, Goldstein: A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. in Human molecular genetics 2009
The crystal structure of Hikeshi explains how Hikeshi participates in the regulation of nuclear import through the recognition of FG-Nups and which part of Hikeshi affects its binding to Hsp70 (show HSP70 Antibodies).
identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein, Hikeshi (coded by the C11orf73 gene) binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers.
Acts as a specific nuclear import carrier for hsp70 nucleoporin-dependent translocation of ATP-bound hsp70 proteins into the nucleus. hsp70 proteins import is required to protect cells from heat shock damages (By similarity).
, lethal, Chr 7, Rinchik 6