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Acts as a specific nuclear import carrier for hsp70 nucleoporin-dependent translocation of ATP-bound hsp70 proteins into the nucleus. Additionally we are shipping C11orf73 Antibodies (33) and many more products for this protein.
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The crystal structure of Hikeshi explains how Hikeshi participates in the regulation of nuclear import through the recognition of FG-Nups and which part of Hikeshi affects its binding to Hsp70 (show HSP70 Proteins).
identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein, Hikeshi (coded by the C11orf73 gene) binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers.
Acts as a specific nuclear import carrier for hsp70 nucleoporin-dependent translocation of ATP-bound hsp70 proteins into the nucleus. hsp70 proteins import is required to protect cells from heat shock damages (By similarity).
, lethal, Chr 7, Rinchik 6