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Induces contraction of stomach muscle (By similarity). Additionally we are shipping Chromosome 12 Open Reading Frame 39 Antibodies (25) and many more products for this protein.
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Human C12orf39 ELISA Kit for Sandwich ELISA - ABIN830436
Gu, Ma, Gu, Zhang, Yan, Li, Wang, Ding, Yin, Fan, Peng: Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes. in Peptides 2015
The results suggest that C12orf39, CSTA (show CSTA ELISA Kits), and CALCB (show CALCB ELISA Kits) are novel ATF4 (show ATF4 ELISA Kits) target genes, and that C12orf39 promoter activity is activated by ATF4 (show ATF4 ELISA Kits) through amino acid response element.
Circulating spexin levels are low in T2DM patients and negatively related to blood glucose and lipids suggesting that the peptide may play a role in glucose and lipid metabolism in T2DM.
Data from ligand-receptor interaction studies suggest that human spexin-1 and zebrafish spexin-2 activate galanin (show GAL ELISA Kits) receptors GALR2 (show GALR2 ELISA Kits)/GALR3 (show GALR3 ELISA Kits) (but not GALR1 (show GALR1 ELISA Kits)); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2 (show GALR2 ELISA Kits)/GALR3 (show GALR3 ELISA Kits).
newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses
Taken together, although C12ORF39 is not a secreted small peptide, it can also be secreted to play a role in the biological functions of the placenta.
Induces contraction of stomach muscle (By similarity).
, neuropeptide Q