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Chromosome 12 Open Reading Frame 5 Proteins (C12orf5)

C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. Additionally we are shipping Chromosome 12 Open Reading Frame 5 Antibodies (109) and Chromosome 12 Open Reading Frame 5 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C12orf5 57103 Q9NQ88
C12orf5 319801 Q8BZA9
C12orf5 615392 Q1JQA7
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Top Chromosome 12 Open Reading Frame 5 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,704.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,718.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,718.83
Details
HOST_Escherichia coli (E. coli) Human TAT tag   0.005 mg Log in to see 2 to 3 Days
$178.75
Details
HOST_Escherichia coli (E. coli) Human TAT tag   100 μg Log in to see 9 to 11 Days
$545.60
Details

C12orf5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Cow (Bovine)

Top referenced Chromosome 12 Open Reading Frame 5 Proteins

  1. Human C12orf5 Protein expressed in Escherichia coli (E. coli) - ABIN667299 : Bensaad, Cheung, Vousden: Modulation of intracellular ROS levels by TIGAR controls autophagy. in The EMBO journal 2009 (PubMed)
    Show all 2 references for ABIN667299

More Proteins for Chromosome 12 Open Reading Frame 5 (C12orf5) Interaction Partners

Human Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer.

  2. TIGAR knockdown reduced tumor growth rate.

  3. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (show TP53 Proteins) mutation.

  4. TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection.

  5. The Cdk5 (show CDK5 Proteins)-AMT (show AMT Proteins) signal pathway involved in regulation of DDR (show DDR1 Proteins) by TIGAR.

  6. miR (show MLXIP Proteins)-144 targeted TIGAR, inhibited proliferation, enhanced apoptosis, and increased autophagy in A549 and H460 cells

  7. Results revealed that TIGAR inhibits both apoptosis and autophagy.

  8. TIGAR is correlated with maximal standardized uptake value on FDG (show SMUG1 Proteins)-PET and survival in non-small cell lung cancer.

  9. Data show targeting MUC1 (show MUC1 Proteins)-C is synergistic with bortezomib (BTZ (show CASC3 Proteins)) in suppressing p53 (show TP53 Proteins)-inducible regulator of glycolysis and apoptosis (TIGAR)-mediated regulation of reactive oxygen species levels for combining GO-203 with BTZ (show CASC3 Proteins) in BTZ (show CASC3 Proteins) resistance.

  10. The kinetic properties and the structural similarity of the best substrates of TIGAR make it unlikely that TIGAR modulates cellular fructose 2,6-bisphosphate levels directly.

Mouse (Murine) Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  2. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 Proteins) or TAp73 (show TP73 Proteins).

  3. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  4. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (show TXN Proteins) nuclear translocation.

  5. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  6. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  7. p53 (show TP53 Proteins)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  8. p53 (show TP53 Proteins) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (show TP53 Proteins) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Chromosome 12 Open Reading Frame 5 (C12orf5) Protein Profile

Protein Summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene names and symbols associated with C12orf5

  • chromosome 1 open reading frame, human C12orf5 (C1H12ORF5)
  • chromosome 12 open reading frame 5 (c12orf5)
  • chromosome 12 open reading frame 5 (LOC100226990)
  • chromosome 12 open reading frame 5 (C12orf5)
  • chromosome 5 open reading frame, human C12orf5 (C5H12orf5)
  • RIKEN cDNA 9630033F20 gene (9630033F20Rik)
  • AA793651 protein
  • AI595337 protein
  • C12orf5 protein
  • C79710 protein
  • C85509 protein
  • FR2BP protein
  • Tigar protein

Protein level used designations for C12orf5

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR , chromosome 12 open reading frame 5 , fructose-2,6-bisphosphate 2-phosphatase , transactivated by NS3TP2 protein

GENE ID SPECIES
419040 Gallus gallus
100145723 Xenopus (Silurana) tropicalis
100226990 Taeniopygia guttata
57103 Homo sapiens
734566 Xenopus laevis
615392 Bos taurus
319801 Mus musculus
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