TIGAR Products
(TP53 induced glycolysis regulatory phosphatase (TIGAR))
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This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008].
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Featured TIGAR Categories
TIGAR Antibodies
High quality antibodies with extensive validation data.
TIGAR Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TIGAR Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7153207
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN671286
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB
Validations
- (1)
Cat. No.
ABIN1538901
Quantity
400 μL
Datasheet
Datasheet
Recommended TIGAR ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971306
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6206069
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN2870279
Quantity
96 tests
Datasheet
Datasheet
Recommended TIGAR Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125420
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347100
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3095990
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TIGAR products
: "TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells." in: Oncology letters, Vol. 9, Issue 2, pp. 569-574, (2015) (PubMed).: "Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death." in: Oncogene, Vol. 30, Issue 9, pp. 1127-34, (2011) (PubMed).
: "The regulation of energy generating metabolic pathways by p53." in: Cancer biology & therapy, Vol. 5, Issue 12, pp. 1610-3, (2007) (PubMed).
: "TIGAR, a p53-inducible regulator of glycolysis and apoptosis." in: Cell, Vol. 126, Issue 1, pp. 107-20, (2006) (PubMed).
: "Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells." in: Biochemical and biophysical research communications, Vol. 302, Issue 1, pp. 12-6, (2003) (PubMed).
: "TP53: a key gene in human cancer." in: Biochimie, Vol. 84, Issue 1, pp. 83-93, (2002) (PubMed).
Synonyms and alternative names related to TIGAR
Trp53 induced glycolysis repulatory phosphatase (Tigar), AA793651, AI595337, C79710, C85509, TigarProtein level used designations for TIGAR
- TP53-induced glycolysis and apoptosis regulator
- fructose-2,6-bisphosphatase TIGAR
- probable fructose-2,6-bisphosphatase TIGAR
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