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Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Additionally we are shipping Chromosome 12 Open Reading Frame 52 Antibodies (22) and many more products for this protein.
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The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1 (show RBPJ Proteins)-interacting protein.
RITA (show ZNF331 Proteins) overexpression increased expression of p53 (show TP53 Proteins) and Fbxw7 (show FBXW7 Proteins) and downregulated expression of cyclin D1 (show CCND1 Proteins), cyclin E (show CCNE1 Proteins), CDK2 (show CDK2 Proteins), Hes-1 and NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins). These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.
human RITA (show ZNF331 Proteins), binding to Drosophila Su(H (show RBPJ Proteins)) and tubulin (show TUBB Proteins), cannot influence the Notch (show NOTCH1 Proteins) signalling pathway in the fly
RITA (show ZNF331 Proteins) might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).
chromosome 12 open reading frame 52
, RBP-J interacting and tubulin associated
, RBPJ-interacting and tubulin-associated protein