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Chromosome 12 Open Reading Frame 52 Proteins (C12orf52)

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Additionally we are shipping Chromosome 12 Open Reading Frame 52 Antibodies (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C12orf52 84934 Q96K30
Mouse C12orf52 C12orf52 100764 Q9D1H0
C12orf52 288683 Q2KJ10
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Top Chromosome 12 Open Reading Frame 52 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
Yeast Xenopus laevis His tag 1 mg Log in to see 56 to 66 Days
$2,607.00
Details
Yeast Rat His tag 1 mg Log in to see 56 to 66 Days
$2,665.67
Details
Yeast REACT_Panda His tag 1 mg Log in to see 56 to 66 Days
$2,700.50
Details
Yeast Cow His tag 1 mg Log in to see 56 to 66 Days
$2,700.50
Details
HOST_Human Human Un-conjugated 20 μg Log in to see 9 to 11 Days
$785.40
Details

C12orf52 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
Rat (Rattus)

More Proteins for Chromosome 12 Open Reading Frame 52 (C12orf52) Interaction Partners

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1 (show RBPJ Proteins)-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. RITA (show ZNF331 Proteins) overexpression increased expression of p53 (show TP53 Proteins) and Fbxw7 (show FBXW7 Proteins) and downregulated expression of cyclin D1 (show CCND1 Proteins), cyclin E (show CCNE1 Proteins), CDK2 (show CDK2 Proteins), Hes-1 and NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins). These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  2. human RITA (show ZNF331 Proteins), binding to Drosophila Su(H (show RBPJ Proteins)) and tubulin (show TUBB Proteins), cannot influence the Notch (show NOTCH1 Proteins) signalling pathway in the fly

  3. RITA (show ZNF331 Proteins) might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Chromosome 12 Open Reading Frame 52 (C12orf52) Protein Profile

Protein Summary

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Gene names and symbols associated with C12orf52

  • chromosome 12 open reading frame 52 (C12orf52)
  • chromosome 12 open reading frame 52 (c12orf52)
  • chromosome 17 open reading frame, human C12orf52 (C17H12orf52)
  • RIKEN cDNA 1110008J03 gene (1110008J03Rik)
  • similar to RIKEN cDNA 1110008J03 (RGD1306772)
  • AI853657 protein
  • C12orf52 protein
  • C86297 protein
  • Rita protein

Protein level used designations for C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPECIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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