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anti-Chromosome 12 Open Reading Frame 65 (C12orf65) Antibodies

May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion (By similarity).. Additionally we are shipping C12orf65 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
C12orf65 91574 Q9H3J6
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Top anti-C12orf65 Antibodies at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: C12orf65  Sample Tissue: Jurkat Whole Cell lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of C12orf65 expression in transfected 293T cell line by C12orf65 MaxPab polyclonal antibody.Lane 1: FLJ38663 transfected lysate(18.26 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 11 to 16 Days
$553.14
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$742.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB   0.1 mL Log in to see 8 to 11 Days
$439.69
Details

C12orf65 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human
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Top referenced anti-C12orf65 Antibodies

  1. Human Polyclonal C12orf65 Primary Antibody for WB - ABIN530060 : Kogure, Hikawa, Hagihara, Tochio, Koshiba, Inoue, Güntert, Kigawa, Yokoyama, Nameki: Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65. in Proteins 2012 (PubMed)

More Antibodies against C12orf65 Interaction Partners

Human Chromosome 12 Open Reading Frame 65 (C12orf65) interaction partners

  1. We demonstrate that the identical nonsense mutation in C12orf65 can result in different clinical features

  2. our study delineates the broad spectrum of C12orf65 defects and establishes a distinct genotype-phenotype correlation. The obligatory clinical triad is optic atrophy, peripheral neuropathy, and spastic paraparesis.

  3. The C12orf65 gene encodes a mitochondrial matrix protein that is critical for the release of newly synthesized proteins from mitochondrial ribosomes.

  4. Truncating mutations in C12ORF65 lead to a variable phenotype with intellectual disability, spastic paraplegia, and ophthalmoplegia in 2 patients.

  5. This work describes a mutation in the C12orf65 gene that causes recessive form of CMT6 and confirms the role of mitochondrial dysfunction in this complex axonal neuropathy.

  6. A homozygous mutation of C12orf65 causes spastic paraplegia with optic atrophy and neuropathy.

  7. Knockdown of C12orf65 resulted in increased reactive oxidative species production and apoptosis, leading to inhibition of cell proliferation.

  8. C12orf65 might play a role in recycling abortive peptidyl-tRNA species, released from the ribosome during the elongation phase of translation.

C12orf65 Antigen Profile

Protein Summary

May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion (By similarity).

Gene names and symbols associated with C12orf65

  • chromosome 12 open reading frame 65 (C12orf65) antibody
  • COXPD7 antibody
  • SPG55 antibody

Protein level used designations for C12orf65

probable peptide chain release factor C12orf65, mitochondrial

GENE ID SPECIES
91574 Homo sapiens
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