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Claudin 16 Proteins (CLDN16)

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Additionally we are shipping Claudin 16 Antibodies (56) and Claudin 16 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLDN16 10686 Q9Y5I7
CLDN16 114141 Q925N4
Rat CLDN16 CLDN16 155268 Q91Y55
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Top Claudin 16 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

CLDN16 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Claudin 16 (CLDN16) Interaction Partners

Human Claudin 16 (CLDN16) interaction partners

  1. CLDN16 mutations are associated with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis.

  2. 1,25(OH)2 VitD transcriptionally inhibits renal claudin-16 expression by a mechanism sensitive to CaSR (show CASR Proteins) and Mg(2 (show MUC7 Proteins)+).

  3. A novel CLDN16 mutation has been identified in a large consanguineous family with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis.

  4. These results suggest that STX8 (show STX8 Proteins) mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney.

  5. Six different mutations of CLDN16 were detected (five missense and one nonsense); three of the missense mutations were previously unknown (p.Cys80Tyr, p.Lys183Glu, and p.Gly233Arg).

  6. A novel mutation of CLDN16 gene is responsible for familial hypomagnesaemia in Turkish children.

  7. Claudin-16 plays a role beyond that of an initial metastasis repressor in breast cancer.

  8. Claudin 16 gene revealed homozygosity for the p.K183E(AAA (show APP Proteins)>GAA (show GAA Proteins)) C. 547A>G indicating the diagnosis of hypomagnesemia with hypercalciuria and nephrocalcinosis.

  9. Multiple distinct mutations in the CLDN16 and CLDN19 (show CLDN19 Proteins) genes have been found responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

  10. Elevated CLDN16 gene expression was suggested to be involved in the development of breast cancer and to be a biomarker and target treatment for breast cancer.

Cow (Bovine) Claudin 16 (CLDN16) interaction partners

  1. Claudin-16 sequences were not usually amplified from a small number of sperm cells (< or =10 cells) but claudin-16 DNA sequences were occasionally detected when a large number of sperm cells (> or =50 cells) were present.

  2. Renal lesions in Japanese Black cattle are not necessarily associated with homozygous deletion of the CL-16 gene.

Mouse (Murine) Claudin 16 (CLDN16) interaction partners

  1. 1,25(OH)2 VitD transcriptionally inhibits renal claudin-16 expression by a mechanism sensitive to CaSR (show CASR Proteins) and Mg(2 (show MCOLN1 Proteins)+).

  2. Mg(2 (show MCOLN1 Proteins)+)-loaded animals displayed hypermagnesemia with increasing urine Mg(2 (show MCOLN1 Proteins)+)/Ca(2 (show CA2 Proteins)+) levels paralleled by a decrease in claudin-16 protein and mRNA in the kidney.

  3. data suggest that claudin-16 forms a non-selective paracellular cation channel (show TRPV1 Proteins), rather than a selective Mg(2 (show MCOLN1 Proteins)+)/Ca(2 (show CA2 Proteins)+) channel as previously proposed

  4. Perturbation in salt and acid-base metabolism in CLDN16 knockout mice has its origin in the defective cation permeability selectivity of the thick ascending limb of the nephron.

  5. Insights into driving forces and paracellular permeability from claudin-16 knockdown mouse

  6. Claudin-16 and claudin-19 (show CLDN19 Proteins) interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium.

Claudin 16 (CLDN16) Protein Profile

Protein Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.

Gene names and symbols associated with Claudin 16 Proteins (CLDN16)

  • claudin 16 (CLDN16)
  • claudin 16 (Cldn16)
  • claudin 16 (LOC100356384)
  • claudin-16 protein
  • CLDN16 protein
  • HOMG3 protein
  • Pcln1 protein

Protein level used designations for Claudin 16 Proteins (CLDN16)

claudin 16 , PCLN-1 , claudin-16 , hypomagnesemia 3, with hypercalciuria and nephrocalcinosis , paracellin-1 , CL-16 , H59D2a protein

GENE ID SPECIES
429147 Gallus gallus
740268 Pan troglodytes
10686 Homo sapiens
608218 Canis lupus familiaris
100302019 Sus scrofa
282184 Bos taurus
114141 Mus musculus
155268 Rattus norvegicus
100356384 Oryctolagus cuniculus
101105382 Ovis aries
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