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anti-Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Antibodies

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. Additionally we are shipping F2RL1 Kits (34) and F2RL1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
F2RL1 2150 P55085
F2RL1 14063 P55086
F2RL1 116677 Q63645
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Top anti-F2RL1 Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p) Human, Vascular smooth muscle: Formalin-Fixed Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of Pancreas using anti- F2RL1 antibody ABIN122391 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Human Adrenal (formalin-fixed, paraffin-embedded) stained with F2RL1 antibody ABIN337049 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IHC (p) Anti-F2RL1 antibody  ABIN1049230 IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-F2RL1 antibody  ABIN1049231 IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 200 μg Log in to see 9 to 11 Days
$378.40
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$347.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

F2RL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine)

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Rat (Rattus)


Top referenced anti-F2RL1 Antibodies

  1. Human Polyclonal F2RL1 Primary Antibody for WB - ABIN2788314 : Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013 (PubMed)

More Antibodies against F2RL1 Interaction Partners

Human Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. Data suggest that thrombin (show F2 Antibodies) can directly activate PAR2 vasorelaxation, signal transduction (stimulating both calcium and MAP kinase (show MAPK1 Antibodies) responses), and triggering beta-arrestin recruitment (both beta-arrestin 1 (show ARRB1 Antibodies) and 2).

  2. Activation of PAR-2 by SLIGRL, a PAR-2 specific ligand, leads to dual phosphorylation of both catalytic sites but primarily regulated eNOS (show NOS3 Antibodies)-Thr (show TRH Antibodies)-495 phosphorylation with no change in nitric oxide production.

  3. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Antibodies) signaling, resulting in RelA (show NFkBP65 Antibodies) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  4. This study provides evidence for the major role of PAR-2 in the pathogenesis of gastroesophageal reflux disease (GERD) and GERD-associated mucosal alterations.

  5. PAR-2 expression is increased on CD14 (show NDUFA2 Antibodies)++CD16 (show CD16 Antibodies)+ monocytes in the peripheral blood of subjects with severe asthma and may be a biomarker of asthma severity.

  6. PAR-2 contributes to the progression of pulmonary fibrosis, and targeting PAR-2 may be a promising therapeutic strategy for treating pulmonary fibrosis.

  7. Binding of the PH domain of PAR-2 enables breast cancer growth and extravillous trophoblast invasion.

  8. Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 (show MARK2 Antibodies) and PAR-2) associate with breast cancer outcome in an estrogen receptor (ER (show ESR1 Antibodies))-dependent manner.

  9. Results show that exposure of bronchial epithelial cells to Aspergillus fumigatus extract suppressed poly I:C and HRV16 signaling via a mechanism shown to involve activation of PAR-2 and PTPN11 (show PTPN11 Antibodies).

  10. alpha-Enolase (show ENO1 Antibodies) increases after injury and may activate pulmonary endothelial cells and prime PMNs through plasmin (show PLG Antibodies) activity and PAR-2 activation

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.

  2. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Antibodies) signaling, resulting in RelA (show NFkBP65 Antibodies) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  3. Tryptase (show TPSAB1 Antibodies) and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin (show OVA Antibodies)-induced atopic-like dermatitis

  4. This study reveals, for the first time, an important role for PAR2 in allergic lung inflammation

  5. HAI-1 (show SPINT1 Antibodies) may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase (show MAPK14 Antibodies) signaling.

  6. PAR2 activation through endogenous mast cell tryptase activity could be required, at least partially, to mediate CCL11 (show CCL11 Antibodies)-induced eosinophil migration

  7. These studies identify the thrombin receptor (show F2R Antibodies) as a powerful extracellular regulatory switch that could be readily targeted to improve myelin production in the face of white matter injury and disease.

  8. PAR2 knockout prevented bone cancer-related pain behaviours and associated neurochemical changes in dorsal root ganglion and dorsal horn.

  9. TR deficiency inhibits osteoclastogenesis by decreasing RANKL/OPG (show TNFSF11 Antibodies) ratio, resulting in a high bone mass phenotype

  10. These findings indicate that hematopoietic TF-PAR2 signaling plays a pivotal role in the hepatic inflammatory responses, steatosis, and hepatic insulin (show INS Antibodies) resistance that lead to systemic insulin (show INS Antibodies) resistance and type 2 diabetes in obesity.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. PAR1 (show F2R Antibodies) and PAR2 regulate endothelial NO synthase (show NOS Antibodies) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

F2RL1 Antigen Profile

Protein Summary

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Gene names and symbols associated with F2RL1

  • Proteinase-activated receptor 2 (par2) antibody
  • coagulation factor II (thrombin) receptor-like 1 (F2RL1) antibody
  • coagulation factor II (thrombin) receptor-like 1 (F2rl1) antibody
  • Gpcr11 antibody
  • GPR11 antibody
  • Par-2 antibody
  • Par2 antibody

Protein level used designations for F2RL1

Proteinase-activated receptor 2 , G-protein coupled receptor 11 , coagulation factor II receptor-like 1 , protease-activated receptor 2 , proteinase-activated receptor 2 , thrombin receptor-like 1 , Protease-activated receptor-2 , proteinase-activated receptor-2 , Proteinase-activated receptor-2 G protein-coupled receptor 11 , Proteinase-activated receptor-2, G protein-coupled receptor 11 , PAR-2

GENE ID SPECIES
100195488 Salmo salar
2150 Homo sapiens
14063 Mus musculus
116677 Rattus norvegicus
526525 Bos taurus
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