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Coagulation Factor II (thrombin) Receptor-Like 2 Proteins (F2RL2)

F2RL2 encodes a member of the PARD protein family. Additionally we are shipping F2RL2 Antibodies (37) and F2RL2 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F2RL2 2151 O00254
F2RL2 14064 O08675
Rat F2RL2 F2RL2 29636 Q920E1
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Top F2RL2 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days

F2RL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) Interaction Partners

Human Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) interaction partners

  1. Knockdown of the polarity protein Par3 reversed the effects of Galpha13 (show GNA13 Proteins) knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.

  2. Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation.

  3. TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (show NOS3 Proteins)-Thr (show TRH Proteins)-495 with minimal phosphorylation of eNOS (show NOS3 Proteins)-Ser (show SIGLEC1 Proteins)-1177 with no change in nitric oxide production.

  4. Shp2 (show PTPN11 Proteins) promotes metastasis of prostate cancer by attenuating the PAR3/PAR6 (show PARD6A Proteins)/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition

  5. study indicated a potential molecular basis for cell growth-promoting function of PARD3 (show PARD3 Proteins) by modulating the Hippo pathway signaling in response to cell contact and cell polarity signals

  6. PAR3-mutant proteins exhibit a relative reduction in the ability to mediate formation of tight junctions and actin-based protrusions and activate STAT3 (show STAT3 Proteins) at cell confluence.

  7. PAR3 and aPKC control the organization of the Golgi through CLASP2 (show CLASP2 Proteins) phosphorylation.

  8. Data show that increased partitioning defective 3 (Par-3) expression is associated with distant metastasis and poor survival rates in patients with hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  9. These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR (show JTB Proteins) activation, such as the activation of vascular-protective Tie2 (show TEK Proteins) by noncanonical PAR3 activation.

  10. In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin (show CDH1 Proteins), leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav.

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) interaction partners

  1. Simultaneous depletion of PAR-1 (show MARK2 Proteins) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.

  2. these data point to a novel kallikrein 6 (show KLK1 Proteins) -signaling axis in neurons that is mediated by PAR1 (show F2R Proteins) and PAR2 (show F2RL1 Proteins) and is positioned to contribute to neurodegeneration

  3. Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (show F3 Proteins)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)

  4. PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (show F2R Proteins)-type thrombin (show F2 Proteins) receptors

  5. Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (show F2RL3 Proteins) by the active site of thrombin (show F2 Proteins).

F2RL2 Protein Profile

Protein Summary

This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins\; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with F2RL2

  • coagulation factor II (thrombin) receptor-like 2 (f2rl2)
  • coagulation factor II (thrombin) receptor-like 2 (F2RL2)
  • coagulation factor II (thrombin) receptor-like 2 (F2rl2)
  • par-3 family cell polarity regulator (PARD3)
  • par-3 partitioning defective 3 homolog (C. elegans) (PARD3)
  • ASIP protein
  • Baz protein
  • F730031A08 protein
  • PAR-3 protein
  • PAR3 protein
  • PAR3alpha protein
  • PARD-3 protein
  • PARD3A protein
  • SE2-5L16 protein
  • SE2-5LT1 protein
  • SE2-5T2 protein

Protein level used designations for F2RL2

proteinase-activated receptor 3 , Coagulation factor II receptor-like 2 (protease-actovated receptor 3) , protease-activated receptor 3 , proteinase-activated receptor-3 , thrombin receptor-like 2 , PAR-3 , Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2) , coagulation factor II receptor-like 2 , CTCL tumor antigen se2-5 , PAR3-alpha , atypical PKC isotype-specific interacting protein , atypical PKC isotype-specific-interacting protein , bazooka , par-3 family cell polarity regulator alpha , par-3 partitioning defective 3 homolog , partitioning defective 3 homolog , par3 , partitioning-defective 3 protein , partitioning-defective protein 3 homolog

100148468 Danio rerio
2151 Homo sapiens
14064 Mus musculus
29636 Rattus norvegicus
512581 Bos taurus
56288 Homo sapiens
420468 Gallus gallus
477953 Canis lupus familiaris
527964 Bos taurus
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