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CDNA1 encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Additionally we are shipping Codanin 1 Antibodies (44) and and many more products for this protein.
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The missense substitution in CDAN1, C15ORF41, encodes a novel restriction endonuclease in congenital dyserythropoietic anemia type I.
The authors propose that Codanin-1 acts as a negative regulator of Asf1 (show SRSF1 Proteins) function in chromatin assembly.
A link between mutant codanin-1 and the aberrant localization of HP1 alpha (show CBX5 Proteins) is supported by the finding that codanin-1 can be coimmunoprecipitated by anti-HP1 alpha (show CBX5 Proteins) antibodies erythroblasts from patients with congenital dyserythropoietic anemia type 1.
This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis.
, congenital dyserythropoietic anemia, type I
, discs lost homolog
, congenital dyserythropoietic anemia type I