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anti-Cofactor of BRCA1 (COBRA1) Antibodies

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). Additionally we are shipping COBRA1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COBRA1 25920 Q8WX92
COBRA1 311796  
COBRA1 58202 Q8C4Y3
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Top anti-COBRA1 Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB COBRA1 Antibody (Center) western blot analysis in 293 cell line lysates (35µg/lane).This demonstrates the COBRA1 antibody detected the COBRA1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated WB COBRA1 Antibody (Center) (ABIN658581) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the COBRA1 antibody detected the COBRA1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image COBRA1 antibody detects COBRA1 protein at nucleus on HBL435 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded HBL435 xenograft. COBRA1 antibody , dilution: 1:500. IHC-P Image COBRA1 antibody detects COBRA1 protein at nucleus on mouse intestine by immunohistochemical analysis. Sample: Paraffin-embedded mouse intestine. COBRA1 antibody , dilution: 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 6 to 11 Days
$498.57
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit FITC ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

COBRA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)
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Top referenced anti-COBRA1 Antibodies

  1. Human Polyclonal COBRA1 Primary Antibody for EIA, WB - ABIN953646 : Sun, Watkins, Blair, Moskaluk, Ghosh, Jiang, Li: Deregulation of cofactor of BRCA1 expression in breast cancer cells. in Journal of cellular biochemistry 2008 (PubMed)
    Show all 4 references for ABIN953646

  2. Human Polyclonal COBRA1 Primary Antibody for WB - ABIN658581 : Narita, Yung, Yamamoto, Tsuboi, Tanabe, Tanaka, Yamaguchi, Handa: NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. in Molecular cell 2007 (PubMed)
    Show all 2 references for ABIN658581

  3. Human Monoclonal COBRA1 Primary Antibody for WB - ABIN782439 : Aiyar, Sun, Blair, Moskaluk, Lu, Ye, Yamaguchi, Mukherjee, Ren, Handa, Li: Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. in Genes & development 2004 (PubMed)
    Show all 2 references for ABIN782439

More Antibodies against COBRA1 Interaction Partners

Human Cofactor of BRCA1 (COBRA1) interaction partners

  1. both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG.

  2. These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A (show WHSC2 Antibodies) and NELF-B, relative to other factors in the overall gene induction sequence.

  3. data show that NELF (show NELF Antibodies) subunits exhibit highly specific subcellular localizations, such as in NELF (show NELF Antibodies) bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF (show NELF Antibodies) from cells can lead to enlarged and/or multiple nuclei

  4. NELF-C (show TH1L Antibodies) and NELF-D (show TH1L Antibodies) are highly related or identical to the protein called TH1 (show TH1L Antibodies), of unknown function. NELF-B and NELF-C (show TH1L Antibodies) or NELF-D (show TH1L Antibodies) are integral subunits that bring NELF-A (show WHSC2 Antibodies) and NELF-E (show RDBP Antibodies) together. [NELF-B] [NELF-C (show TH1L Antibodies)]

  5. COBRA1 may directly modulate AP-1 (show FOSB Antibodies) pathway and, therefore, may play important roles in cell proliferation, differentiation, apoptosis, and oncogenesis.

  6. COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines.

  7. Decreasing NELF also correlated with displacement of a positioned nucleosome and increased acetylation of histone H4, suggesting coupling of transcription elongation and chromatin remodeling

  8. Negative elongation factor (NELF (show RDBP Antibodies)) is a four subunit transcription factor. Our results point to a surprising role of NELF (show NELF Antibodies) in the 3' end processing of histone mRNAs and suggest that NELF (show NELF Antibodies) is a new factor that coordinates mRNA processing in transcription.

  9. COBRA1 may coordinate multiple steps in ligand-dependent gene expression, which in turn ensures both the quantity and quality of hormone-stimulated gene products

  10. a lack of COBRA1 expression in breast carcinoma may serve as a useful indicator for poor prognosis.

Mouse (Murine) Cofactor of BRCA1 (COBRA1) interaction partners

  1. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 (show BRCA1 Antibodies) in antagonizing COBRA1-dependent transcription program during mammary gland development.

  2. Human and mouse Nelfb encode proteins translated from a non-AUG (CUG) start codon. The majority of mouse tissues examined express the isoform translated from the CUG start codon, but a small number of tissues also express a shorter isoform of the same apparent size as the AUG-initiated isoform.

  3. Cobra1 Is Required for TrkC (show NTRK3 Antibodies)-Induced Apoptosis.

  4. genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing.

  5. findings also indicate that Cobra1 helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes

COBRA1 Antigen Profile

Protein Summary

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1\; MIM 603555) and SPT5 (SUPT5H\; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003

Gene names and symbols associated with COBRA1

  • cofactor of BRCA1 (LOC100219583) antibody
  • cofactor of BRCA1 (COBRA1) antibody
  • negative elongation factor complex member B (NELFB) antibody
  • negative elongation factor complex member B (nelfb) antibody
  • cofactor of BRCA1 (cobra1) antibody
  • negative elongation factor complex member B (Nelfb) antibody
  • negative elongation factor complex member B, Cobra1 (Nelfb) antibody
  • A730008L03Rik antibody
  • AB041607 antibody
  • AI663983 antibody
  • bZ1O1.4 antibody
  • Cobra1 antibody
  • cobra2 antibody
  • fe01e12 antibody
  • LOC100219583 antibody
  • MGC131073 antibody
  • Nelf-b antibody
  • RGD1307832 antibody
  • wu:fe01e12 antibody
  • zgc:55628 antibody

Protein level used designations for COBRA1

cofactor of BRCA1 , negative elongation factor B , negative elongation factor B-like , negative elongation factor protein B , ortholog of human cofactor of BRCA1 (COBRA1)

GENE ID SPECIES
100219583 Taeniopygia guttata
736409 Pan troglodytes
512799 Bos taurus
417254 Gallus gallus
393137 Danio rerio
704966 Macaca mulatta
491230 Canis lupus familiaris
496936 Xenopus (Silurana) tropicalis
734938 Xenopus laevis
100438513 Pongo abelii
100469627 Ailuropoda melanoleuca
100514560 Sus scrofa
100538856 Meleagris gallopavo
100560093 Anolis carolinensis
101103711 Ovis aries
25920 Homo sapiens
311796 Rattus norvegicus
58202 Mus musculus
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