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The protein encoded by CCDC39 is involved in the motility of cilia and flagella. Additionally we are shipping CCDC39 Kits (12) and and many more products for this protein.
Showing 10 out of 37 products:
Human Polyclonal CCDC39 Primary Antibody for IHC, IHC (p) - ABIN4288604
Merveille, Davis, Becker-Heck, Legendre, Amirav, Bataille, Belmont, Beydon, Billen, Clément, Clercx, Coste, Crosbie, de Blic, Deleuze, Duquesnoy, Escalier, Escudier, Fliegauf, Horvath, Hill, Jorissen et al.: CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. ... in Nature genetics 2011
Show all 2 references for ABIN4288604
Hamster Polyclonal CCDC39 Primary Antibody for EIA, WB - ABIN951106
Simpson, Wellenreuther, Poustka, Pepperkok, Wiemann: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. in EMBO reports 2001
Lung disease was worse in those with IDA (show IDUA Antibodies)/CA/MTD (show MT1E Antibodies) ultrastructural defects, most of whom had biallelic mutations in ccdc39.
This study shows that CCDC39 and CCDC40 (show CCDC40 Antibodies) mutations are the major cause of Primary ciliary dyskinesia in patients with the previously termed "radial spoke defect".
Aiming to delineate the CCDC39/CCDC40 mutation spectrum and associated phenotypes, a large cohort of patients with IDA defects were screened. Biallelic CCDC39 or CCDC40 mutations were identified in 30/34 unrelated families with IDA defects.
Functional analyses indicated that CCDC39 localizes to ciliary axonemes and is essential for assembly of inner dynein arms and the dynein regulatory complex.
Ccdc39 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
FAP59 forms a complex with FAP172, and serves as a molecular ruler for the axonemal 96-nm repeat structures. [FAP59]
The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat. Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14).
coiled-coil domain containing 39
, coiled-coil domain-containing protein 39
, Coiled-coil domain-containing protein 39