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CCDC88A encodes a member of the Girdin family of coiled-coil domain containing proteins. Additionally we are shipping Coiled-Coil Domain Containing 88A Kits (2) and many more products for this protein.
Showing 10 out of 71 products:
Human Polyclonal CCDC88A Primary Antibody for IHC, ELISA - ABIN1533173
Simpson, Martin, Evans, Kerr, James, Parton, Teasdale, Wicking: A novel hook-related protein family and the characterization of hook-related protein 1. in Traffic (Copenhagen, Denmark) 2005
Show all 2 references for 1533173
Human Polyclonal CCDC88A Primary Antibody for IHC, ELISA - ABIN1532146
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005
Show all 2 references for 1532146
Human Polyclonal CCDC88A Primary Antibody for IF (p), IHC (p) - ABIN755587
Ni, Fang, Tong, Tong, Yi, Qiu, Wang, Tong: Girdin regulates the migration and invasion of glioma cells via the PI3K?Akt signaling pathway. in Molecular medicine reports 2015
Tyrosine Phosphorylation of an Actin-Binding Protein (show PFN1 Antibodies) Girdin Specifically Marks Tuft Cells in Human and Mouse Gut (show GUSB Antibodies)
This study aimed to prove the participation of mTORC2 (show CRTC2 Antibodies)/Akt (show AKT1 Antibodies) in F-actin assembling in early-stage cleavage of mouse fertilized eggs via the function of Girdin.
Akt (show AKT1 Antibodies)-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.
GIV expression is up-regulated in liver after fibrotic injury and is required for hepatic stellate cells activation.Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.
GIV and its substrate Galphai3 (show GNAI3 Antibodies) are recruited to active integrin complexes
findings suggest a potential role of Girdin/kinesin-1 interaction in the regulation of neuroblast migration in the postnatal brain
Girdin phosphorylation at Y1798 was found at focal adhesions in NIH3T3 cells. Such phosphorylation was found where migration defects occurred in Girdin KO mice.
Girdin phosphorylation at S1416 induced by Akt (show AKT1 Antibodies) is crucial for NMDA receptor activation associated with LTP (show SCP2 Antibodies).
Girdin was identified as a new and major regulator of the insulin (show INS Antibodies) signal in myoblasts and skeletal muscle.
These results demonstrate that girdin and its phosphorylation play an important role in neonatal vascular development and in pathological neovascularization in the retina.
Tyrosine Phosphorylation of an Actin-Binding Protein (show KPTN Antibodies) Girdin Specifically Marks Tuft Cells in Human and Mouse Gut (show GUSB Antibodies)
Overexpression of girdin is associated with invasion of hepatocellular carcinoma.
Heterotrimeric G protein signaling via GIV/Girdin is a ubiquitous mechanism in health and disease, and can be a target for molecular therapies. (Review)
miR (show MLXIP Antibodies)-101 inhibits cell proliferation, migration and invasion in hepatocellular carcinoma through downregulating Girdin.
Phosphorylation of GIV at Tyr (show TYR Antibodies)-1764/Tyr (show TYR Antibodies)-1798 is also required to enhance PI3K (show PIK3CA Antibodies)-Akt (show AKT1 Antibodies) signaling and tumor cell migration in response to integrin stimulation, indicating that GIV functions in Tyr (show TYR Antibodies)(P)-dependent integrin signaling.
CCDC88A is essential for multiple aspects of normal development and loss of CCDC88A is a cause of the PEHO syndrome phenotype.
GIV is an essential upstream component that couples InsR (show INSR Antibodies) to G-protein signaling to enhance the metabolic insulin (show INS Antibodies) response, and impairment of such coupling triggers IR.
Girdin regulates the migration and invasion of glioma cells via the PI3K (show PIK3CA Antibodies)-Akt (show AKT1 Antibodies) signaling pathway.
The expression of Girdin protein in invasive breast cancer is strongly associated with lymph node metastasis.
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
coiled-coil domain containing 88A
, hook-related protein 1
, golgi-associated microtubule-binding protein HOOK3-like
, Akt-phosphorylation enhancer
, Hook-related protein 1
, coiled-coil domain-containing protein 88A
, g alpha-interacting vesicle-associated protein
, girders of actin filament
, Galpha-interacting vesicle-associated protein
, AKT-phosphorylation enhancer
, girders of actin filaments