Collagen, Type I, alpha 2 Proteins (COL1A2)

COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Additionally we are shipping Collagen, Type I, alpha 2 Antibodies (97) and Collagen, Type I, alpha 2 Kits (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL1A2 1278 P08123
COL1A2 12843 Q01149
Rat COL1A2 COL1A2 84352 P02466
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Top Collagen, Type I, alpha 2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,678.50
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$656.00
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HOST_Escherichia coli (E. coli) Dog GST tag,His tag   100 μg Log in to see 15 to 18 Days
$768.00
Details

COL1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Collagen, Type I, alpha 2 (COL1A2) Interaction Partners

Human Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. Identify PDGFRbeta as a driver in activating Akt (show AKT1 Proteins)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.

  2. Flightless-I (Drosophila) homolog (FLII (show FLII Proteins)) activates TGFbeta1 (show TGFB1 Proteins)-mediated expression of COL1A2 gene.

  3. In the individuals with a COL1A2 mutation, 80% (8/10) of those with a glycine substitution located C terminal of p.Gly211 exhibited DGI (show DSG1 Proteins) in both dentitions while no individual (0/5) with a mutation N-terminal of this point (p = 0.007) exhibited DGI (show DSG1 Proteins) in either dentition.

  4. COL1A2 expression was positively related to tumor size, depth of invasion, and to lower overall survival of gastric cancer patients.

  5. the present study demonstrated that the INS (show INS Proteins)/DEL polymorphism in the 3'UTR of COL1A2 is able to interfere with the interaction between miRNA and mRNA. In addition, it is the first study, to the best of our knowledge, to indicate that the minor allele (Del) is associated with a reduced risk of developing osteoporosis.

  6. These findings may improve understanding of the pathogenic gene mutation spectrum and the clinical manifestations of mutations of COL1A1 (show COL1A1 Proteins) and COL1A2 genes in Chinese patients with OI.

  7. THBS2 (show THBS2 Proteins), but not COL1A2 and SPP1 (show SPP1 Proteins), may serve as an indicator of gastric cancer prognosis.

  8. spine radiographs and charts of 437 patients (227 female) with osteogenesis imperfecta caused by mutations in COL1A1 (show COL1A1 Proteins) or COL1A2 were evaluated and compared the relationship between scoliosis, genotype and bisphosphonate treatment history.

  9. The overexpression of let7b was observed to upregulate the protein expression levels of COL1A1 (show COL1A1 Proteins) and COL1A2, while knockdown of let7b reduced the levels of COL1A1 (show COL1A1 Proteins) and COL1A2 in skin fibroblasts

  10. Internal mammary artery tissue from active smokers contains decreased amounts of type 1 collagen and decorin (show DCN Proteins).

Cow (Bovine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen

  2. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

Mouse (Murine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. Identify PDGFRbeta as a driver in activating Akt (show AKT1 Proteins)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.

  2. Insulin receptor substrate-1 (show IRS1 Proteins) time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (show MLXIP Proteins)-342

  3. Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin (show CDH2 Proteins) pathway.

  4. evidence that FOXL2 (show FOXL2 Proteins) modulates Col1a2 transcription through interaction with a response element 65 Kb upstream of the transcription start site

  5. Data indicate that insulin-like growth factor 1 (IGF1 (show IGF1 Proteins)) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6 (show LARP6 Proteins)) expression via a posttranscriptional mechanism.

  6. The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis to modulate the expression of its target genes while also attenuating TGFbeta (show TGFB1 Proteins)-induced expression of type I collagen and myofibroblast phenotype conversion marker genes

  7. Decreased expression of Krox20 (show EGR2 Proteins) in mice causes down-regulation of Col1A2 expression, degeneration of the aortic leaflets and disorganization of the extracellular matrix, causing valvular dysfunction.

  8. Resveratrol effectively inhibits collagen I synthesis in IGF-1 (show IGF1 Proteins)-stimulated colonic fibroblasts, partly by inhibiting IGF-1R (show IGF1R Proteins) activation, and SIRT1 (show SIRT1 Proteins) is also responsible for the process.

  9. Sp7/Osterix (show SP7 Proteins) induces the mouse Col1a2 expression via the proximal promoter in osteoblastic cells in association with osteoblast differentiation.

  10. Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 (show LIN28A Proteins) upregulates collagen expression in glomerular mesangial cells from diabetic mice.

Pig (Porcine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

Zebrafish Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. ven though in adult bone, skin and scales equal amounts of a1(col1a1a) a2(col1a2) and a3(col1a2)chains are present, the presented data suggest a tissue-specific stoichiometry and/or post-translational modification status for collagen type I

Collagen, Type I, alpha 2 (COL1A2) Protein Profile

Protein Summary

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Gene names and symbols associated with COL1A2

  • collagen type I alpha 2 (LOC100860940)
  • collagen, type 1, alpha 2 (col1a2)
  • collagen, type I, alpha 2 (COL1A2)
  • collagen, type I, alpha 2 (Col1a2)
  • collagen, type I, alpha 2 (col1a2)
  • AA960264 protein
  • AI325291 protein
  • alpha2(I) protein
  • Col1a-2 protein
  • Cola-2 protein
  • Cola2 protein
  • hm:zehn2357 protein
  • OI4 protein
  • oim protein
  • wu:fa98d05 protein
  • wu:fa99g10 protein
  • wu:fb04c08 protein
  • wu:fb11d06 protein
  • zehn2357 protein

Protein level used designations for COL1A2

procollagen, type I, alpha 2 , alpha 2(I) collagen , alpha-2 type I collagen , alpha-2(1) collagen , collagen alpha 2(I) chain , collagen alpha-2(I) chain , alpha 2(I)-collagen , collagen I, alpha-2 polypeptide , collagen of skin, tendon and bone, alpha-2 chain , type I procollagen , COL1A2 gene exons 8 through 12 , type I procollagen pro-alpha 2 chain , alpha 2(I) procollagen , collagen I alpha-2 polypeptide , collagen COL1A2 , osteogenesis imperfecta , alpha 2 type I collagen , collagen a2(I)

GENE ID SPECIES
100860940 Capra hircus
380419 Xenopus laevis
396243 Gallus gallus
1278 Homo sapiens
403824 Canis lupus familiaris
282188 Bos taurus
100008997 Oryctolagus cuniculus
12843 Mus musculus
84352 Rattus norvegicus
100719158 Cavia porcellus
100626716 Sus scrofa
336471 Danio rerio
100135811 Oncorhynchus mykiss
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