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The protein encoded by CSF3R is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. Additionally we are shipping CSF3R Kits (31) and CSF3R Proteins (20) and many more products for this protein.
Showing 10 out of 191 products:
Human Monoclonal CSF3R Primary Antibody for FACS, WB - ABIN4899922
Shao, Xu, Jing, Tweardy: Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Monoclonal CSF3R Primary Antibody for EIA, WB - ABIN114568
Baars, De Ruijter, Smedts, Van Niekerk, Poels, Seldenrijk, Ramaekers: The applicability of a keratin 7 monoclonal antibody in routinely Papanicolaou-stained cytologic specimens for the differential diagnosis of carcinomas. in American journal of clinical pathology 1994
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Human Polyclonal CSF3R Primary Antibody for EIA, FACS - ABIN951155
Germeshausen, Kratz, Ballmaier, Welte: RAS and CSF3R mutations in severe congenital neutropenia. in Blood 2009
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Human Polyclonal CSF3R Primary Antibody for ELISA, WB - ABIN4313030
Meenhuis, Verwijmeren, Roovers, Touw: The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor. in The Biochemical journal 2011
Human Monoclonal CSF3R Primary Antibody for ELISA (Capture), FACS - ABIN4899923
deBruin, Lincoln, Hartley, Shehabeldin, Van, Szilvassy: Most purported antibodies to the human granulocyte colony-stimulating factor receptor are not specific. in Experimental hematology 2010
Human Monoclonal CSF3R Primary Antibody for FACS - ABIN319850
Nicholson, Oates, Harpur, Ziemiecki, Wilks, Layton: Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. in Proceedings of the National Academy of Sciences of the United States of America 1994
Human Monoclonal CSF3R Primary Antibody for FACS - ABIN4896902
Radomska, Alberich-Jordà, Will, Gonzalez, Delwel, Tenen: Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα. in The Journal of clinical investigation 2012
Human Monoclonal CSF3R Primary Antibody for FACS - ABIN4896903
Dror, Durie, Ginzberg, Herman, Banerjee, Champagne, Shannon, Malkin, Freedman: Clonal evolution in marrows of patients with Shwachman-Diamond syndrome: a prospective 5-year follow-up study. in Experimental hematology 2002
Human Polyclonal CSF3R Primary Antibody for IF (p), IHC (p) - ABIN742275
Tajima, Waki, Tsuchiya, Hoshi et al.: Granulocyte colony-stimulating factor-producing undifferentiated carcinoma of the colon mimicking a pulmonary giant cell carcinoma: a case showing overexpression of CD44 along with highly ... in International journal of clinical and experimental pathology 2014
biallelic CSF3R mutations were identified In the group of congenital neutropenia patients; CSF3R mutant clones are highly dynamic and may disappear and reappear during continuous granulocyte colony-stimulating factor (G-CSF (show CSF3 Antibodies)) therapy. The time between the first detection of CSF3R mutations and overt leukemia is highly variable
Co-occurrence of mutations in CSF3R and CEBPA (show CEBPA Antibodies) in a well-defined AML (show RUNX1 Antibodies) subset, which uniformly responds to JAK (show JAK3 Antibodies) inhibitors; this paves the way to personalized clinical trials for this disease.
The quantitative methods used in this study have shown non-altered expression levels of different microglial markers (Iba-1 (show AIF1 Antibodies), Cd11b (show ITGAM Antibodies) and CD68 (show CD68 Antibodies)), together with increased expression of IL6 (show IL6 Antibodies), IL10RA (show IL10RA Antibodies), colony stimulating factor (show CSF2 Antibodies) 3 receptor and toll-like receptor 7 (show TLR7 Antibodies) in the thalamus in FFI, which explains the seemingly contradictory results of the previous studies.
This study proposes that acquisition of CSF3R mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE (show ELANE Antibodies) mutations evade the proapoptotic activity of the Neutrophil Elastase (show ELANE Antibodies) mutants in SCN (show SRI Antibodies) patients.
CSF3R expression is significantly upregulated in human masticatory mucosa during wound healing
Results indicate that granulocyte-colony stimulating factor receptor, tissue factor, and vascular endothelial growth factor receptor bound vascular endothelial growth factor expression as well as their co-expression might influence breast cancer biology.
The Colony-Stimulating Factor (show CSF2 Antibodies) 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK (show JAK3 Antibodies) Inhibition, and Mimics T618I
CSF3R mutations, mechanisms of mutations, and their contributions to the myeloid malignancies (Review)
In conclusion, rhCSF3 can promote melanocyte proliferation through CSF3R without affecting tyrosinase (show TYR Antibodies) activity
CSF3R mutations are associated with congenital neutropenia.
Anti-G-CSF receptor rapidly halted the progression of established disease in collagen Ab-induced arthritis in mice. Neutrophil accumulation in joints was inhibited, without rendering animals neutropenic, suggesting an effect of G-CSF receptor blockade on neutrophil homing to inflammatory sites.
this study shows that dorsal root ganglion neurons cultured in G-CSF (show CSF3 Antibodies) failed to respond to G-CSF (show CSF3 Antibodies) in vitro, and Csf3r gene expression could not be detected in dorsal root ganglion neurons by single-cell RT-PCR
Thr (show TRH Antibodies)-615 and Thr (show TRH Antibodies)-618 sites of membrane-proximal mutations are part of an O-linked glycosylation cluster. Mutation at these sites prevents O-glycosylation of CSF3R and increases receptor dimerization.
Fbw7 (show FBXW7 Antibodies) together with GSK3beta (show GSK3b Antibodies) negatively regulates G-CSFR expression and its downstream signaling.
G-CSFR signaling interacts with retinoic acid receptors in the regulation of myeloid differentiation
Expression of truncated G-CSFR significantly shortens the latency of AML (show RUNX1 Antibodies) in a G-CSF (show CSF3 Antibodies)-dependent fashion and it is associated with a distinct AML (show RUNX1 Antibodies) presentation characterized by higher blast counts and more severe myelosuppression.
G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance, ultimately leading to hematopoietic stem and progenitor cell mobilization.
Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF (show CSF3 Antibodies)-induced expansion of myeloid progenitor cells.
murine granulocyte colony-stimulating factor receptor binds to a low molecular weight ligand
Mice with truncated G-CSF (show CSF3 Antibodies) receptors have neutropenia, susceptibility to infection, and bone marrow maturation arrest similar to severe congenital neutropenic humans, suggesting a role of receptor truncation mutations in SCN (show SRI Antibodies) pathology.
GCSF (show CSF3 Antibodies)/GCSFR is a conserved signaling system for facilitating the production of multiple myeloid cell lineages, as well as for early myeloid cell migration.
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.
granulocyte colony-stimulating factor receptor
, colony stimulating factor 3 receptor (granulocyte)
, granulocyte colony-stimulating factor receptor-like
, CD114 antigen
, G-CSF receptor
, granulocyte stimulating factor receptor