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Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes.
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CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability.
Rax (show RAX Antibodies) and Crx cooperatively transactivate Rhodopsin (show RHO Antibodies) and cone opsin (show RHO Antibodies) promoters and an optimum Rax (show RAX Antibodies) expression level to transactivate photoreceptor gene expression exists.
E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease.
The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat (show AANAT Antibodies) expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis
We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2 (show KCNV2 Antibodies).
In Crx-knockout mice vasopressin (show AVP Antibodies) mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm.
Data have identified a novel retinal SAM (show TTN Antibodies) domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.
Our results show that NRL (show NRL Antibodies) and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis (show CISH Antibodies)-regulatory module
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
A change in the suprachiasmatic nuclei of the Crx-deficient mouse might explain the observed circadian differences between the knockout mouse and wild-type mouse.
Binds and transactivates the sequence 5'-TAATC-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
cone-rod homeobox protein