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CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. Additionally we are shipping Connector Enhancer of Kinase Suppressor of Ras 1 Proteins (3) and many more products for this protein.
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Human Monoclonal CNKSR1 Primary Antibody for IF, WB - ABIN968649
Therrien, Wong, Kwan, Rubin: Functional analysis of CNK in RAS signaling. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 2 references for 968649
tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.
CNK1 mediates ephrinB1 (show EFNB1 Antibodies) signaling that promotes cell migration through RhoA (show RHOA Antibodies) and JNK (show MAPK8 Antibodies) activity.
Studies indicate that CNK1-driven proliferation relies on Akt (show AKT1 Antibodies)-dependent phosphorylation and inactivation of FoxO (show FOXO3 Antibodies) proteins.
These findings identify CNK1 as a new positive regulator of insulin (show INS Antibodies) signaling.
Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.
CNK1 promotes oncogenic signalling through Akt (show AKT1 Antibodies) in breast cancer cell lines and tumours.
hCNK1 associates with Rhophilin (show RHPN1 Antibodies) and RalGDS (show RALGDS Antibodies), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (show HOMER1 Antibodies) to mediate cross talk between the two pathways
Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras.
CNK1 couples a subset of Rho exchange factors to activation of the JNK (show MAPK8 Antibodies) MAP kinase (show MAPK1 Antibodies) pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho.
CNK1 allows cross-talk between Src (show SRC Antibodies) and Raf-1 (show RAF1 Antibodies) and is essential for the full activation of Raf-1 (show RAF1 Antibodies)
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
connector enhancer of kinase suppressor of ras 1
, connector enhancer of kinase suppressor of Ras 1
, connector enhancer of kinase suppressor of ras 1-like
, CNK homolog protein 1
, connector enhancer of KSR 1