You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Core-Binding Factor, beta Subunit (CBFB) Antibodies

The protein encoded by CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesi. Additionally we are shipping Core-Binding Factor, beta Subunit Proteins (12) and Core-Binding Factor, beta Subunit Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBFB 361391  
CBFB 12400 Q08024
CBFB 865 Q13951
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Core-Binding Factor, beta Subunit Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of CBFB Antibody (Center) (ABIN390892) in HL-60 cell line lysates (35 µg/lane). CBFB (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with CBFB Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HuvEc/HeLa cells, using CBF beta Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human heart tissue, using CBF beta Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: CBFB  Sample Tissue: Jurkat Whole Cell lysates  Antibody Dilution: 1.0 µg/mL CBFB is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Anti-CBFB antibody IHC staining of human breast, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959286 concentration 10 ug/ml. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated ChIP, ELISA 50 μL Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 ug whole cell lysate) A:293T B:Raji , 12% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry (IHC) analyzes of PEBP2beta antibody in paraffin-embedded human heart tissue. Western blot (WB) analysis of PEBP2beta antibody in extracts from HUVEC 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Sheep Un-conjugated ICC, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details

CBFB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) ,


Mouse (Murine) ,
, ,

Human , , ,
, , ,
,
, , , , ,

Top referenced anti-Core-Binding Factor, beta Subunit Antibodies

  1. Human Polyclonal CBFB Primary Antibody for IHC, ELISA - ABIN1533882 : Hajra, Collins: Structure of the leukemia-associated human CBFB gene. in Genomics 1995 (PubMed)
    Show all 2 references for ABIN1533882

  2. Human Polyclonal CBFB Primary Antibody for EIA, WB - ABIN452819 : Andersen, Christensen, Thorsen, Schepeler, Sørensen, Verspaget, Simon, Kruhøffer, Aaltonen, Laurberg, Ørntoft: Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. in British journal of cancer 2009 (PubMed)

More Antibodies against Core-Binding Factor, beta Subunit Interaction Partners

Rhesus Monkey Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. Vif (show BTG1 Antibodies) proteins of human and simian immunodeficiency viruses require cellular CBFbeta to degrade APOBEC3G (show APOBEC3G Antibodies).

  2. simian immunodeficiency virus (SIV) Vif (show BTG1 Antibodies) binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G (show APOBEC3G Antibodies)

Mouse (Murine) Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. Core binding factor beta deficiency in chondrocytes caused a decrease of protein levels of Runx transcription factors by accelerating polyubiquitination-mediated proteosomal degradation in vitro

  2. Cbfb plays an important role in the stabilization of Runx family proteins; and that Runx2 (show RUNX2 Antibodies) protein stability is less dependent on Cbfb in calvariae than in cartilaginous limb skeletons

  3. findings indicate that Cbfbeta stabilizes Runx2 (show RUNX2 Antibodies) in osteoblasts by forming a complex and thus facilitates the proper maintenance of bone mass, particularly cortical bone

  4. Runx/Cbfb signaling regulate androgen receptor (show AR Antibodies) pathway, but does not affect the circulating testosterone levels or the enzymatic conversion to DHT.

  5. Cbfb deficiency results in differentiation blocks and stem cell expansion in hematopoiesis.

  6. Cbfbeta functions in upregulating Ihh (show IHH Antibodies) expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR (show PTH1R Antibodies) expression to enhance chondrocyte differentiation.

  7. results demonstrate that Cbfbeta mediates cartilage and bone development by interacting with Runx1 (show RUNX1 Antibodies) and Runx2 (show RUNX2 Antibodies) to regulate the expressions of Col (show HDAC1 Antibodies) X and Osx (show SP7 Antibodies) for chondrocyte and osteoblast development

  8. It is concluded from the result that miR (show MLXIP Antibodies)-125b is a key regulatory factor of osteoblastic differentiation by directly targeting Cbfbeta and indirectly acting on Runx2 (show RUNX2 Antibodies) at an early stage osteoblastic differentiation.

  9. data provide, to our knowledge, the first evidence for the presence of B-1 progenitor cells in the fetal liver that arise independently of HSCs and implicate Cbfbeta as a critical molecule in the development of this lineage

  10. Cbfbeta-SMMHC (show MYH11 Antibodies) and Nras (show NRAS Antibodies)(G12D) promote the survival of preleukemic myeloid progenitors primed for leukemia by activation of the MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies)/Bim (show BCL2L11 Antibodies) axis, and define Nras (show NRAS Antibodies)(LSL-G12D); Cbfb(56M) mice as a valuable genetic model for the study of AML (show RUNX1 Antibodies) therapies.

Zebrafish Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. characterization of cbfbeta gene

  2. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  3. Data demonstrate for the first time an essential role of JunB (show JUNB Antibodies)-CBFbeta signaling for maintaining sarcomere architecture and function.

Human Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. Thus, an NGF (show NGFB Antibodies)/TrkA (show NTRK1 Antibodies)-MAPK (show MAPK1 Antibodies)-CBFbeta pathway converges with Islet1 (show ISL1 Antibodies)-Runx1 (show RUNX1 Antibodies) signaling to promote Runx1 (show RUNX1 Antibodies)/CBFbeta holocomplex formation and nonpeptidergic nociceptor maturation.

  2. Our findings demonstrate that HSPCs exposed to non-cytotoxic levels of environmental chemicals and chemotherapeutic agents are prone to topoisomerase II (show TOP2 Antibodies)-mediated DNA damage at the leukemia-associated genes MLL (show MLL Antibodies) and CBFB.

  3. These results provide important information on the assembly of the Vif (show BTG1 Antibodies)-CUL5 (show CUL5 Antibodies)-E3 ubiquitin ligase (show MUL1 Antibodies) and identify a new viV binding interface with CBF-beta at the C-terminus of HIV-1 Vif (show BTG1 Antibodies).

  4. CBF-beta promoted steady-state levels of HIV-1 Vif (show BTG1 Antibodies) by inhibiting the degradation of HIV-1 Vif (show BTG1 Antibodies) through the proteasome pathway.

  5. CBFB contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB-SMMHC (show MYH11 Antibodies) in proliferation and maintenance of the leukemic phenotype.

  6. we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation

  7. suggest that a different mechanism exists for the Vif (show BTG1 Antibodies)-APOBEC interaction and that non-primates are not suitable animal models for exploring pharmacological interventions that disrupt Vif (show BTG1 Antibodies)-CBF-beta interaction

  8. Our findings indicate that RUNX1 (show RUNX1 Antibodies) and CBF-beta cooperate in cells to modulate HIV-1 replication

  9. Suggest that CBFbeta retention in the midbody during cytokinesis reflects a novel function that contributes to epigenetic control.

  10. Transcriptional analysis revealed that upon fusion protein knockdown, a small subset of the CBFbeta-MYH11 (show MYH11 Antibodies) target genes show increased expression, confirming a role in transcriptional repression

Core-Binding Factor, beta Subunit (CBFB) Antigen Profile

Protein Summary

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit\; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16

Gene names and symbols associated with CBFB

  • core-binding factor, beta subunit (Cbfb) antibody
  • core-binding factor, beta subunit (CBFB) antibody
  • core-binding factor, beta subunit (LOC100230400) antibody
  • core-binding factor, beta subunit (cbfb) antibody
  • core binding factor beta subunit (Cbfb) antibody
  • core-binding factor, beta subunit (LOC100340362) antibody
  • core-binding factor, beta subunit (LOC100359284) antibody
  • core binding factor beta (Cbfb) antibody
  • nuclear transcription factor-Y alpha (Nfya) antibody
  • nuclear transcription factor-Y beta (Nfyb) antibody
  • AI893578 antibody
  • CBF-B antibody
  • cbf-beta antibody
  • Cbfb antibody
  • cbfbeta antibody
  • Nfya antibody
  • PEA2 antibody
  • pea2-beta antibody
  • Pebp2 antibody
  • pebp2-beta antibody
  • PEBP2B antibody
  • Pebpb2 antibody
  • unp1266 antibody

Protein level used designations for CBFB

core binding factor beta , core-binding factor subunit beta , core-binding factor, beta subunit , core binding factor beta subunit , CBF-beta , PEA2-beta , PEBP2-beta , SL3-3 enhancer factor 1 subunit beta , SL3/AKV core-binding factor beta subunit , polyomavirus enhancer-binding protein 2 beta subunit , CCAAT-binding transcription factor subunit B , core-binding factor beta , SL3-3 enhancer factor 1 beta subunit , polyomavirus enhancer binding protein 2, beta subunit , CAAT box DNA-binding protein subunit A , CAAT-box DNA-binding protein subunit A , CBF-B , NF-YA , nuclear transcription factor Y subunit A , nuclear transcription factor Y subunit alpha , CAAT box DNA-binding protein subunit B , CAAT-box DNA-binding protein subunit B , CBF-A , CCAAT binding transcription factor of CBF-B/NFY-B , CCAAT-binding transcription factor subunit A , NF-YB , nuclear transcription factor - Y beta , nuclear transcription factor Y subunit B , nuclear transcription factor Y subunit beta

GENE ID SPECIES
361391 Rattus norvegicus
695767 Macaca mulatta
100230400 Taeniopygia guttata
100270773 Xenopus (Silurana) tropicalis
100313579 Saccoglossus kowalevskii
100340362 Oryctolagus cuniculus
100359284 Oryctolagus cuniculus
12400 Mus musculus
30744 Danio rerio
446882 Xenopus laevis
395257 Gallus gallus
865 Homo sapiens
479690 Canis lupus familiaris
614678 Bos taurus
29508 Rattus norvegicus
25336 Rattus norvegicus
Selected quality suppliers for anti-Core-Binding Factor, beta Subunit (CBFB) Antibodies
Did you look for something else?