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The protein encoded by CNIH2 is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. Additionally we are shipping Cornichon Homolog 2 (Drosophila) Antibodies (26) and many more products for this protein.
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Significant upregulation of CNIH-2 mRNA expression was found in schizophrenia.
Cornichon-2 and cornichon-3 (show CNIH3 Proteins) dictate subunit-specific AMPA (show GRIA3 Proteins) receptor trafficking and synaptic transmission.
Transmembrane AMPA (show GRIA3 Proteins) receptor regulatory proteins and cornichon-2 allosterically regulate AMPA (show GRIA3 Proteins) receptor antagonists and potentiators.
Cornichon homolog 2 (CNIH-2) associates with TARP gamma-8 in hippocampus postsynaptic densities; CNIH-2 protein levels are diminished in transmembrane AMPA (show GRIA3 Proteins) receptor regulatory protein (show TGFB1 Proteins) (TARP) gamma-8 knockout mice.
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants.
protein cornichon homolog 2
, cornichon homolog 2 (Drosophila)
, cornichon homolog 2-like
, cornichon homolog 2
, cornichon homolog 3
, protein cornichon homolog 3
, cornichon-like protein