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Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping CRYGC Proteins (9) and many more products for this protein.
Showing 10 out of 39 products:
Cow (Bovine) Polyclonal CRYGC Primary Antibody for WB - ABIN2774014
Gonzalez-Huerta, Messina-Baas, Cuevas-Covarrubias: A family with autosomal dominant primary congenital cataract associated with a CRYGC mutation: evidence of clinical heterogeneity. in Molecular vision 2007
Human Polyclonal CRYGC Primary Antibody for IF (p), IHC (p) - ABIN1714542
Aoki, Ogino, Tomita, Hara, Kunisada: Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. in PLoS ONE 2016
the G129C mutation in gammaC-crystallin, which is associated with autosomal dominant congenital nuclear cataract, perturbed the unfolding process by promoting the accumulation of two distinct aggregation-prone intermediates under mild denaturing conditions.
Exome sequencing in developmental eye disease leads to identification of causal variants in GJA8 (show GJA8 Antibodies), CRYGC, PAX6 (show PAX6 Antibodies) and CYP1B1 (show CYP1B1 Antibodies).
We confirm that congenital cataract is associated with a CRYGC gene mutation.
identified a CRYAA (show CRYAA Antibodies) mutation in family A and a CRYGC mutation in family B with congenital cataract
A nonsense mutation c.471G>A in CRYGC is associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree.
Molecular modeling and spectroscopic studies indicated that the mutation impaired the tertiary structure of gamma C crystallin by modifying the H-bonding network in the C-terminal domain.
Two novel nonsynonymous variations and four reported variations in CRYAB (show CRYAB Antibodies), CRYGC, CRYGD (show CRYGD Antibodies), and GJA8 (show GJA8 Antibodies), were observed.
In gammaD-crystallin, methylation is exclusively at Cys (show DNAJC5 Antibodies) 110, whereas in gammaC- and gammaB-crystallins, the principal methylation site is Cys (show DNAJC5 Antibodies) 22 with minor methylation at Cys (show DNAJC5 Antibodies) 79
the loss of interactions of T5P mutant of the gammaC-crystallin with other crystallins may play a larger role than the protection afforded by chaperone-like activity in Coppock-like cataract.
This is the first case of phenotypic heterogeneity in the primary congenital cataract specifically associated with the R168W mutation in the CRYGC gene.
a 1-bp deletion in gammaC-crystallin leads to cataract.
presence of measurable interactions between MIP26 (show MIP Antibodies) and all crystallins, with the extent of interactions decreasing from alphaA- and alphaB-crystallin (show CRYAB Antibodies) to betaB2- and gammaC-crystallin.
Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
crystallin, gamma C
, gamma-crystallin C
, crystallin, gamma-3
, gamma-crystallin 2-1
, gamma-crystallin 3
, gamma-crystallin IIIA
, crystallin, gamma polypeptide 3