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Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. Additionally we are shipping CUBN Antibodies (48) and CUBN Proteins (14) and many more products for this protein.
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Cubilin deficiency reduces renal salvage and delivery back to the blood of albumin a (show ALB ELISA Kits)nd apolipoprotein (apo)A-I (show APOA ELISA Kits), which decreases blood levels of albumin and apoA-I (show ALB ELISA Kits)/HD
cubilin and megalin (show LRP2 ELISA Kits) mRNA expression is under epigenetic control
plasma membrane binding of Fgf8 (show FGF8 ELISA Kits), and most likely of the Fgf8 (show FGF8 ELISA Kits) family members Fgf17 (show FGF17 ELISA Kits) and Fgf18 (show FGF18 ELISA Kits), to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity.
Impaired protein endocytosis caused by invalidation of ClC-5 (show CLCN5 ELISA Kits) primarily reflects a trafficking defect of megalin (show LRP2 ELISA Kits) and cubilin in PTC (show PTCH1 ELISA Kits).
Cubilin expression is pronounced in the extraembryonic visceral endoderm of embryos. Cubilin, is also expressed by a subpopulation of cells dispersed within the embryonic endoderm having a migratory morphology.
Amn (show TRAF3 ELISA Kits) is an essential component of the Cubn receptor complex
Cubilin is required for embryonic development and is essential for the formation of somites, and definitive endoderm.
Inactivation of RFC1 (show RFC1 ELISA Kits) impacts the expression of several ligands and interacting proteins in the cubilin-amnionless (show AMN ELISA Kits)-megalin (show LRP2 ELISA Kits) complex that are involved in the maternal-fetal transport of folate and other nutrients.
CUBN was associated with albuminuria in type 2 diabetes patients.
The variant rs11254363 of the CUBN gene was associated with a decreased risk of developing congenital heart disease in Han Chinese populations
MA is associated with CVD irrespective of the presence of the CUBN risk allele. These results challenge the concept that albuminuria in the setting of this mutation is benign.
Cubilin haploinsufficiency leads to reduced renal proximal tubular uptake of albumin (show ALB ELISA Kits) and apolipoprotein (apo)A (show APOA ELISA Kits)-I, significantly increasing urinary loss of albumin (show ALB ELISA Kits) and apoA-I (show APOA1 ELISA Kits).
predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL (show NEBL ELISA Kits) common variants in the chromosome 10p13 linkage region
LOS treatment decreased microalbuminuria induced by Cd apparently through a cubilin receptor-dependent mechanism but independent of megalin (show LRP2 ELISA Kits).
Data suggest that endodermal layer of yolk sac (show ADCY10 ELISA Kits) and syncytiotrophoblast/cytotrophoblast cells of placental villi express cubilin mRNA/protein; expression of cubilin mRNA/protein is up-regulated as gestation/placentation progresses.
Single nucleotide polymorphisms in cubilin gene is associated with iron overload.
These data suggest that CUBN is not involved in cleft lip or palate onset in the investigated Italian population
Our genetic screening of 154 families of patients with inherited cobalamin malabsorption revealed population-specific mutations, mutational hotspots, and functionally distinct regions in the three causal genes: CUBN, AMN (show ABCD1 ELISA Kits), and GIF (show GIF ELISA Kits).
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
cubilin (intrinsic factor-cobalamin receptor)
, 460 kDa receptor
, glycoprotein 280
, intrinsic factor-cobalamin receptor
, intrinsic factor-vitamin B12 receptor
, cubilin precursor variant 1
, cubilin precursor variant 2
, intestinal intrinsic factor receptor