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Cyclic Nucleotide Gated Channel alpha 1 Proteins (CNGA1)

The protein encoded by CNGA1 is involved in phototransduction. Additionally we are shipping Cyclic Nucleotide Gated Channel alpha 1 Antibodies (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CNGA1 1259 P29973
CNGA1 12788 P29974
Rat CNGA1 CNGA1 85259 Q62927
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Top Cyclic Nucleotide Gated Channel alpha 1 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

CNGA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Cyclic Nucleotide Gated Channel alpha 1 (CNGA1) Interaction Partners

Cow (Bovine) Cyclic Nucleotide Gated Channel alpha 1 (CNGA1) interaction partners

  1. Conformation changes of CNGA1 associated with its gating function are reported.

  2. Data show that when Pro365 is replaced with a threonine in cyclic nucleotide gated channel alpha 1 (CNGA1), cesium Cs+ permeation is nearly abolished.

  3. Stabilizing the C-helix of intact CNGA1 channels by metal binding to a pair of histidines promoted channel opening.

  4. A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions

  5. Three CNGA1 subunits and a single CNGB1 (show CNGB1 Proteins) subunit form the rod cyclic nucleotide-gated ion channels.

  6. Existence of a strong coupling between the upper portion of the S6 helix provides a simple molecular mechanism for CNGA1 gating.

  7. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry

  8. Data suggest that the native rod cyclic nucleotide-gated (CNG) channel is a tetramer composed of three A1 and one B1 subunit.

  9. Data show that the cyclic nucleotide-gated (CNG) channel contains three CNGA1 subunits and only one CNGB1 (show CNGB1 Proteins) subunit.

  10. Structural models of the tetrameric cyclic nucleotide gated channel alpha 1 from bovine rod is presented.

Human Cyclic Nucleotide Gated Channel alpha 1 (CNGA1) interaction partners

  1. The mut (show MUT Proteins) CNGA1 p.(G513R) protein was largely retained inside the cell rather than being targeted to the plasma membrane, suggesting the absence of cGMP-gated cation channels in the plasma membrane

  2. CNGA1 mutations are one of the most frequent autosomal recessive retinitis pigmentosa-causing mutations in the Japanese patients.

  3. Insulin receptor (IR (show INSR Proteins)), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.

  4. Novel homozygous mutation R28X truncates CNGA1 very prematurely in patients with autosomal recessive retinitis pigmentosa.

  5. isolated an endogenous transcript (anti-CNG1) that is antisense to CNG1 mRNA; data suggest the suppression of CNG(alpha)1 expression by anti-CNG1 may play an important role in neuronal functions, especially in synaptic plasticity and cortical development

  6. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry

  7. The autosomal recessive retinitis pigmentosa in this family is caused by a mutation in CNGA1 gene.

Mouse (Murine) Cyclic Nucleotide Gated Channel alpha 1 (CNGA1) interaction partners

  1. Numb protein (show NUMBL Proteins) interacts with Cnga1 in rod photoreceptor cilia to promote delivery of Cnga1.

  2. Insulin receptor (IR (show INSR Proteins)), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.

  3. that effective knockdown of GUCY2E and CNGA1 expression to counteract loss of PDE6 function may develop into a valuable approach for treating some patients with RP.

  4. Interaction with auxiliary subunit tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) is a major mechanism underlying proper expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and Ih in vivo.

  5. Grb14 (show GRB14 Proteins) is a normal physiological modulator of CNG channel function in vivo.

  6. We demonstrate the association of photoreceptor CNG channels with membrane domains enriched in raft lipids and indicates, for the first time, that raft lipids modulate the plasma membrane localization and functional activity of photoreceptor CNG channels.

Cyclic Nucleotide Gated Channel alpha 1 (CNGA1) Protein Profile

Protein Summary

The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CNGA1

  • hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (HCN1)
  • cyclic nucleotide gated channel alpha 1 (cnga1)
  • cyclic nucleotide gated channel alpha 1 (CNGA1)
  • cyclic nucleotide gated channel alpha 1 (Cnga1)
  • Cncg protein
  • CNCG1 protein
  • CNG protein
  • CNG-1 protein
  • CNG1 protein
  • CNGA1 protein
  • CNGC1 protein
  • HCN protein
  • HCN1 protein
  • RCNC1 protein
  • RCNCa protein
  • RCNCalpha protein
  • RP49 protein
  • xcnga1 protein

Protein level used designations for CNGA1

hyperpolarization activated cyclic nucleotide-gated potassium channel 1 , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 , cyclic nucleotide gated channel alpha 1 , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1-like , cGMP-gated cation channel alpha-1-like , CNG channel alpha-1 , cGMP-gated cation channel alpha-1 , cyclic nucleotide-gated cation channel 1 , cyclic nucleotide-gated channel alpha-1 , cyclic nucleotide-gated channel, photoreceptor , interleukin-1 homologue , rod photoreceptor cGMP-gated channel subunit alpha , CNG-1 , CNG1 , cyclic nucleotide gated channel, cGMP gated , cyclic nucleotide gated chanel (photoreceptor), cGMP gated 1, alpha , cyclic nucleotide gated channel (photoreceptor), cGMP gated , rod photoreceptor cGMP-gated channel alpha-subunit

GENE ID SPECIES
431590 Gallus gallus
471552 Pan troglodytes
538255 Bos taurus
612434 Canis lupus familiaris
701947 Macaca mulatta
704286 Macaca mulatta
733204 Xenopus laevis
739850 Pan troglodytes
741853 Pan troglodytes
100064345 Equus caballus
100386968 Callithrix jacchus
100455135 Pongo abelii
704891 Macaca mulatta
100597149 Nomascus leucogenys
1259 Homo sapiens
12788 Mus musculus
85259 Rattus norvegicus
281700 Bos taurus
403891 Canis lupus familiaris
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