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Cyclin T2 Proteins (CCNT2)

The protein encoded by CCNT2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Additionally we are shipping Cyclin T2 Antibodies (35) and Cyclin T2 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCNT2 905 O60583
CCNT2 72949  
Rat CCNT2 CCNT2 304758  
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Top Cyclin T2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details

CCNT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Cyclin T2 (CCNT2) Interaction Partners

Human Cyclin T2 (CCNT2) interaction partners

  1. the release of P-TEFb (show CCNT1 Proteins) from the 7SK snRNP (show LSM2 Proteins) led to increased synthesis of HEXIM1 (show HEXIM1 Proteins) but not HEXIM2 (show HEXIM2 Proteins)

  2. interaction with pRb (show RB1 Proteins)

  3. CycT2 not only contains two domains that target rna polymerase II but this substrate recognition is necessary for its transcriptional activity via DNA

  4. Data strengthen the hypothesis that Cyclin T2a plays a role in muscle differentiation, and propose PKNalpha (show PKN1 Proteins) as a novel partner of Cyclin T2a in this process.

  5. The results establish that cdk9 (show CDK9 Proteins)/cyclin T2a-mediated coactivation of MyoD (show MYOD1 Proteins) depends on serine 37 phosphorylation.

  6. These results suggest that acetylation of CDK9 (show CDK9 Proteins) is an important posttranslational modification that is involved in regulating P-TEFb (show CCNT1 Proteins) transcriptional elongation function.

  7. TAF7 interacts with the transcription factors, TFIIH and P-TEFb, resulting in the inhibition of their Pol II CTD kinase activities

  8. The tripartite protein-RNA complex formation between Hexim (show HEXIM1 Proteins), Cyclin T (show CCNT1 Proteins) and 7SK snRNA, was analyzed.

Mouse (Murine) Cyclin T2 (CCNT2) interaction partners

  1. both isoforms of Cyclin T2 are able to activate the myogenic program but Cyclin T2b has a predominant role, in particular during the latest stages.

  2. miR (show MLXIP Proteins)-15a inhibited muscle differentiation at least in part by targeting Ccnt2; roles in spermatogenesis.

  3. activation of MyoD (show MYOD1 Proteins)-dependent transcription by cdk9 (show CDK9 Proteins)/cyclin T2

  4. despite numerous matings of heterozygous mice, we observed no CycT2(-/-) embryos, pups, or adult mice. This early lethality could have resulted from decreased expression of critical genes

Cyclin T2 (CCNT2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Cyclin T2 Proteins (CCNT2)

  • cyclin T2 (CCNT2)
  • cyclin T2b (ccnt2b)
  • cyclin T2a (ccnt2a)
  • cyclin T2 (ccnt2)
  • cyclin T2 (Ccnt2)
  • 2900041I18Rik protein
  • C81304 protein
  • CCNT2 protein
  • cycT protein
  • CycT2 protein
  • CycT2b protein
  • fb16c03 protein
  • MGC81210 protein
  • wu:fb16c03 protein
  • wu:fi17h07 protein
  • wu:fj68b10 protein
  • zgc:55357 protein
  • zgc:55690 protein

Protein level used designations for Cyclin T2 Proteins (CCNT2)

cyclin T2 , cyclin-T2 , cyclin-T2-like , SDS-stable vimentin-bound DNA fragment HEF42VIM22 , cyclin T2a , cyclin T2b , subunit of positive elongation transcription factor b

GENE ID SPECIES
100050510 Equus caballus
321464 Danio rerio
327568 Danio rerio
447439 Xenopus laevis
470546 Pan troglodytes
476126 Canis lupus familiaris
100349398 Oryctolagus cuniculus
100412841 Callithrix jacchus
100446291 Pongo abelii
100488125 Xenopus (Silurana) tropicalis
100011986 Monodelphis domestica
100552048 Anolis carolinensis
100599933 Nomascus leucogenys
905 Homo sapiens
424289 Gallus gallus
521089 Bos taurus
72949 Mus musculus
304758 Rattus norvegicus
101106913 Ovis aries
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