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Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) Proteins (CDK5R1)

The protein encoded by CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. Additionally we are shipping CDK5R1 Antibodies (98) and CDK5R1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CDK5R1 8851 Q15078
CDK5R1 12569 P61809
CDK5R1 116671 P61810
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Top CDK5R1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$411.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,816.00
Details
HOST_Escherichia coli (E. coli) Epstein-Barr virus GST tag   1 mg Log in to see 6 to 11 Days
$1,185.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Escherichia coli (E. coli) Epstein-Barr virus Un-conjugated   1 mg Log in to see 3 to 4 Days
$1,306.80
Details

CDK5R1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced CDK5R1 Proteins

  1. Human CDK5R1 Protein expressed in Escherichia coli (E. coli) - ABIN1686721 : Johnson, Beito, Krco, Toft: Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. in Molecular and cellular biology 1994 (PubMed)
    Show all 8 references for ABIN1686721

More Proteins for Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) Interaction Partners

Zebrafish Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) interaction partners

  1. p35 likely acts downstream of egr1 (show EGR1 Proteins) to control the differentiation of Parvalbumin (show PVALB Proteins)+ amacrine cells.

Pig (Porcine) Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) interaction partners

  1. CDK5 (show CDK5 Proteins) mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 was observed in both cerebral cortex and cerebellum at two months of age

Human Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) interaction partners

  1. Under cell-free in vitro conditions, p35 (show ANXA1 Proteins) is covalently modified by SUMO1 (show SUMO1 Proteins). SUMO2 (show SUMO2 Proteins) is conjugated to p35 (show ANXA1 Proteins) in cells. The 2 major SUMO acceptor lysines in p35 (show ANXA1 Proteins) are K246 and K290. Different degrees of oxidative stress resulted in differential p35 (show ANXA1 Proteins) sumoylation.

  2. Cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) is required for motor learning and involved in long-term synaptic plasticity.

  3. Expression of p35 (show ANXA1 Proteins) is upregulated in human pituitary adenomas.

  4. These results reveal a physiological role of p25 (show LCN2 Proteins) production in synaptic plasticity and memory and provide new insights into the function of p25 (show LCN2 Proteins) in Abeta (show APP Proteins)-associated neurotoxicity and Alzheimer's disease-like pathology.

  5. Structural basis for the different stability and activity between the Cdk5 (show CDK5 Proteins) complexes with p35 (show ANXA1 Proteins) and p39 (show JUN Proteins) activators.

  6. Reduced p35 (show ANXA1 Proteins) basal content and down--regulation of CDK5 (show CDK5 Proteins)/p35/p25 by antipsychotics are demonstrated in postmortem prefrontal cortex of schizophrenic subjects.

  7. The present study dissects the role of 3 single nucleotide polymorphisms (rs334558 and rs6438552 of GSK3B, and rs735555 of CDK5R1) in Parkinson's disease pathogenesis among eastern Indians.

  8. p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity.

  9. The decrease in membrane-associated p35 (show ANXA1 Proteins) in socially isolated transgenic mice reduces associated levels of p35 (show ANXA1 Proteins), alpha-CaMKII, and GluR1 (show GRIA1 Proteins) and leads to endocytosis of AMPA (show GRIA3 Proteins) receptors.

  10. CDK5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) may represent a biomarker for prognosis in patients with non-small cell lung cancer

Mouse (Murine) Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) interaction partners

  1. The transiently active CDK5 (show CDK5 Proteins)-p35 complexes limited the LPS (show TLR4 Proteins)-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3 (show SOCS3 Proteins))

  2. Cdk5 (cyclin-dependent kinase 5 (show CDK5 Proteins)) requires p35 regulatory subunit (Cdk5r1) for activation; data suggest Cdk5r1 stability regulates Cdk5 (show CDK5 Proteins) activity in neurons; Cdk5r1 is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.

  3. These data suggest p35 and p39 (show ATP6V0D1 Proteins) have specific and overlapping roles in oligodendrocyte development, some of which may be independent of Cdk5 (show CDK5 Proteins) activation.

  4. Studied the effect of reduced levels of p25 and p35, two proteins required for cdk5 (show CDK5 Proteins) activation, on striatal neurodegeneration using mice with targeted deletion of p35.

  5. p35 interacts with NIF-1 and regulates the subcellular localization of the protein independent of Cdk5 (show CDK5 Proteins)-dependent phosphorylation. ...reveal a new mechanism of p35 in transcriptional regulation that does not require the kinase activity of Cdk5 (show CDK5 Proteins)

  6. Cdk5 (show CDK5 Proteins)/p35 regulates spatial learning and memory.

  7. Our findings suggest that p35/Rac1 signaling is critical in the CDK5 (show CDK5 Proteins) silencing-induced neuroprotection against glutamate (show GRIN1 Proteins) neurotoxicity

  8. provide a mechanistic explanation that Sig-1Rs help maintain proper tau phosphorylation by potentially carrying and providing myristic acid to p35 for enhanced p35 degradation to circumvent the formation of overreactive cdk5/p25

  9. This report shows that herpes simplex virus 1 increases p35 levels, changes the primary localization of CDK-5 (show CDK5 Proteins) from the nucleus to the cytoplasm, and enhances CDK-5 (show CDK5 Proteins) activity during lytic or acute infection.

  10. the effects of p25, although normally attributed to activate CDK5, may be mediated in part by elevated GSK3beta activity.

Cow (Bovine) Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) interaction partners

  1. Data suggest that up-regulation of S100A8 (show S100A8 Proteins) and S100A9 (show S100A9 Proteins) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.

CDK5R1 Protein Profile

Protein Summary

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Gene names and symbols associated with CDK5R1

  • cyclin-dependent kinase 5, regulatory subunit 1 (p35) (cdk5r1-a)
  • cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b)
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35) (CDK5R1)
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1)
  • related RAS viral (r-ras) oncogene homolog (Rras)
  • S100 calcium binding protein A9 (S100A9)
  • transmembrane emp24-like trafficking protein 10 (yeast) (Tmed10)
  • tumor protein, translationally-controlled 1 (TPT1)
  • 1110014C03Rik protein
  • CDK5P35 protein
  • Cdk5r protein
  • CDK5R1 protein
  • D11Bwg0379e protein
  • NCK5A protein
  • p23 protein
  • p24delta1 protein
  • p25 protein
  • P25/P35 protein
  • p35 protein
  • p35nck5a protein
  • PCHK23 protein
  • TCTP protein
  • Tmp21 protein
  • Xp35.1 protein
  • zgc:92814 protein

Protein level used designations for CDK5R1

cyclin-dependent kinase 5, regulatory subunit 1 (p35) , cyclin-dependent kinase 5 regulatory subunit , cyclin-dependent kinase 5 activator 1 , cyclin-dependent kinase 5 regulatory subunit 1 , CDK5 activator 1 , TPKII regulatory subunit , neuronal CDK5 activator , regulatory partner for CDK5 kinase , tau protein kinase II 23kDa subunit , cyclin-dependent kinase 5, regulatory subunit (p35) 1 , p23 , tau protein kinase II 23 kDa subunit , Harvey rat sarcoma oncogene, subgroup R , Harvey rat sarcoma virus oncogene, subgroup R , Ras-related protein R-RAS (P23) , ras-related protein R-Ras , BEE22 , S100 calcium-binding protein A9 , calgranulin-B , neutrophil cytosolic 23 kDa protein , protein S100-A9 , 21 kDa transmembrane-trafficking protein , p24 family protein delta-1 , transmembrane emp24 domain-containing protein 10 , transmembrane protein Tmp21 , transmembrane trafficking protein , growth-related translationally controlled tumor protein , growth-related translationally-controlled tumor protein , translationally-controlled tumor protein homolog

GENE ID SPECIES
373685 Xenopus laevis
436788 Danio rerio
491154 Canis lupus familiaris
714274 Macaca mulatta
747897 Pan troglodytes
100113467 Sus scrofa
8851 Homo sapiens
12569 Mus musculus
116671 Rattus norvegicus
282173 Bos taurus
361568 Rattus norvegicus
532569 Bos taurus
68581 Mus musculus
396363 Gallus gallus
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