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Cysteinyl Leukotriene Receptor 1 Proteins (CYSLTR1)

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Additionally we are shipping CysLTR1 Antibodies (61) and CysLTR1 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYSLTR1 10800 Q9Y271
CYSLTR1 58861 Q99JA4
Rat CYSLTR1 CYSLTR1 114099 Q924T8
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Top CysLTR1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

CYSLTR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Cysteinyl Leukotriene Receptor 1 (CYSLTR1) Interaction Partners

Human Cysteinyl Leukotriene Receptor 1 (CYSLTR1) interaction partners

  1. in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1. This, in turn, would induce enhanced CD4 (show CD4 Proteins)+ T cell responsiveness to cysLTs, T cell activation, and Th2 polarization.

  2. CysLTR-1 and CysLTR-2 (show CYSLTR2 Proteins) are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH.

  3. The 5-LOX (show ALOX5 Proteins)/LTC4 /CysLT1 signaling pathway regulates EGF (show EGF Proteins)-induced cell migration by increasing Tiam1 (show TIAM1 Proteins) expression.

  4. Cysteinyl leukotrienes signaling downstream of CysLT1R in mast cells is differentially regulated by two distinct PKCalpha (show PKCa Proteins) and PKC epsilon (show PRKCE Proteins).

  5. CysLT(1) receptors in endothelial cells translocate to the nucleus in a ligand-independent manner after ischemic insult in vitro, and it is involved in the ischemic injury.

  6. A significant relationship was found between the expression of CysLT1 receptor and GR-beta in nasal polyps (R = .525, P = .04), whereas there was no significant relationship between the expression of CysLT1 receptor and GR-alpha in nasal polyps.

  7. A role of nuclear CysLT(1) receptor signaling in vascular smooth muscle cells inducing gene expression patterns associated with atherosclerosis.

  8. Bronchial mucosal CysLT1 receptor-positive inflammatory cells are present in the bronchial mucosa in COPD (show ARCN1 Proteins) in greatest number in those experiencing a severe exacerbation.

  9. Data suggest that CysLT1 induces chemokine (show CCL1 Proteins)-like effects, supports accumulation and survival of chronic lymphocytic leukemia (CLL) cells in the bone marrow and thus represents a potential treatment target.

  10. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2 (show CYSLTR2 Proteins))R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3 (show ARRB2 Proteins)-, and Rab-5 (show RAB5A Proteins)-dependent manner

Mouse (Murine) Cysteinyl Leukotriene Receptor 1 (CYSLTR1) interaction partners

  1. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3

  2. Involvement of CysLT1R in a model of asthma.

  3. Suggest that myogenic tone is determined by AT1 (show SLC33A1 Proteins) and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation.

  4. The CysLT(1) and CysLT(2 (show CYSLTR2 Proteins)) receptors were primarily localized in neurons, microglia and neutrophils

  5. CysLT1R mediates LTD4-induced activation of microglial cells.

  6. In an animal model of cognition impairment, CysLT1 receptor signaling is identified as proinflammatory and proamyloidogenic.

  7. present novel data that CysLT1R is expressed on ILC2s and LTD potently induces CysLT1R-dependent ILC2 production of IL-4 (show IL4 Proteins), IL-5 (show IL5 Proteins), and IL-13 (show IL13 Proteins)

  8. CysLT1R, CysLT2R (show CYSLTR2 Proteins) and GPR17 (show GPR17 Proteins) might be involved in the MPTP (show PTPN2 Proteins)-induced Parkinson disease damage in mice.

  9. 5-Lipoxygenase (show ALOX5 Proteins) mediates RANKL (show TNFSF11 Proteins)-induced osteoclast formation via the cysteinyl leukotriene receptor 1, and it can serve as a novel therapeutic target for bone-resorption diseases.

  10. Rotenone induced an increased expression of CysLT(1) receptor in BV2 microglial cells.

CysLTR1 (CYSLTR1) Protein Profile

Protein Summary

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.

Gene names and symbols associated with CYSLTR1

  • cysteinyl leukotriene receptor 1 (cysltr1)
  • cysteinyl leukotriene receptor 1 (CYSLTR1)
  • cysteinyl leukotriene receptor 1 (cltr1)
  • CysLT1 receptor (CYCLT1)
  • cysteinyl leukotriene receptor 1 (Cysltr1)
  • cysteinyl leukotriene receptor 1 (LOC100338776)
  • BB147369 protein
  • Cyslt1 protein
  • cysLT1R protein
  • CYSLTR protein
  • CYSLTR1 protein
  • HMTMF81 protein
  • zgc:112062 protein

Protein level used designations for CYSLTR1

cysteinyl leukotriene receptor 1 , G-protein coupled receptor HG55 , LTD4 receptor , cysteinyl leukotriene D4 receptor

GENE ID SPECIES
553675 Danio rerio
608345 Canis lupus familiaris
706663 Macaca mulatta
742228 Pan troglodytes
782045 Bos taurus
100528780 Ictalurus punctatus
100587169 Nomascus leucogenys
397242 Sus scrofa
10800 Homo sapiens
58861 Mus musculus
114099 Rattus norvegicus
100135514 Cavia porcellus
428691 Gallus gallus
100338776 Oryctolagus cuniculus
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